Two Higgs doublet models for the LHC Higgs boson data at s=\sqrt{s}= 7 and 8 TeV

Updated LHC data on the new 126 GeV boson during the 7 and 8 TeV runnings strengthen the standard model Higgs boson interpretation further. Through the global $\chi^2$ analysis, we investigate whether the new particle could be one of the scalar particles in two Higgs doublet models. Four types (Type I, II, X and Y) are comprehensively studied. Taking the recent analysis on the spin-parity of the new boson, we consider two scenarios: the new boson is either the light CP-even one ($h^0$) or the heavy CP-even one ($H^0$). It is found that both scenarios are consistent with the new data, not only in the parameter regions near the decoupling limit but also in other regions far from the decoupling limit. In addition, the current data are compatible with the possibility that the light Higgs boson $h^0$ is hidden in the mass window of 90-100 GeV. The diphoton or $\tau\tau$ channel can provide a probe of this possibility by the enhanced signal rates.Comment: To appear in JHE

OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research

Online application for survival analysis (OASIS) has served as a popular and convenient platform for the statistical analysis of various survival data, particularly in the field of aging research. With the recent advances in the fields of aging research that deal with complex survival data, we noticed a need for updates to the current version of OASIS. Here, we report OASIS 2 (http://sbi.postech.ac.kr/oasis2), which provides extended statistical tools for survival data and an enhanced user interface. In particular, OASIS 2 enables the statistical comparison of maximal lifespans, which is potentially useful for determining key factors that limit the lifespan of a population. Furthermore, OASIS 2 provides statistical and graphical tools that compare values in different conditions and times. That feature is useful for comparing age-associated changes in physiological activities, which can be used as indicators of "healthspan." We believe that OASIS 2 will serve as a standard platform for survival analysis with advanced and user-friendly statistical tools for experimental biologists in the field of aging research.1127Ysciescopu

Trajectory Optimization for Cellular-Enabled UAV with Connectivity and Battery Constraints

In this paper, we address the problem of path planning for a cellular-enabled UAV with connectivity and battery constraints. The UAV's mission is to deliver a payload from an initial point to a final point as soon as possible, while maintaining connectivity with a BS and adhering to the battery constraint. The UAV's battery can be replaced by a fully charged battery at a charging station, which may take some time depending on waiting time. Our key contribution lies in proposing an algorithm that efficiently computes an optimal UAV path in polynomial time. We achieve this by transforming the problem into an equivalent two-level shortest path finding problem over weighted graphs and leveraging graph theoretic approaches. In more detail, we first find an optimal path and speed to travel between each pair of charging stations without replacing the battery, and then find the optimal order of visiting charging stations. To demonstrate the effectiveness of our approach, we compare it with previously proposed algorithms and show that our algorithm outperforms those in terms of both computational complexity and performance. Furthermore, we propose another algorithm that computes the maximum payload weight that the UAV can deliver under the connectivity and battery constraints.Comment: This article was presented in part at the IEEE Vehicular Technology Conference (VTC) 2023-Fal

Metal-organic framework based on hinged cube tessellation as transformable mechanical metamaterial

Mechanical metamaterials exhibit unusual properties, such as negative Poisson???s ratio, which are difficult to achieve in conventional materials. Rational design of mechanical metamaterials at the microscale is becoming popular partly because of the advance in three-dimensional printing technologies. However, incorporating movable building blocks inside solids, thereby enabling us to manipulate mechanical movement at the molecular scale, has been a difficult task. Here, we report a metal-organic framework, self-assembled from a porphyrin linker and a new type of Zn-based secondary building unit, serving as a joint in a hinged cube tessellation. Detailed structural analysis and theoretical calculation show that this material is a mechanical metamaterial exhibiting auxetic behavior. This work demonstrates that the topology of the framework and flexible hinges inside the structure are intimately related to the mechanical properties of the material, providing a guideline for the rational design of mechanically responsive metal-organic frameworks

Heterologous Expression of Plant Cell Wall Degrading Enzymes for Effective Production of Cellulosic Biofuels

A major technical challenge in the cost-effective production of cellulosic biofuel is the need to lower the cost of plant cell wall degrading enzymes (PCDE), which is required for the production of sugars from biomass. Several competitive, low-cost technologies have been developed to produce PCDE in different host organisms such as Escherichia coli, Zymomonas mobilis, and plant. Selection of an ideal host organism is very important, because each host organism has its own unique features. Synthetic biology-aided tools enable heterologous expression of PCDE in recombinant E. coli or Z. mobilis and allow successful consolidated bioprocessing (CBP) in these microorganisms. In-planta expression provides an opportunity to simplify the process of enzyme production and plant biomass processing and leads to self-deconstruction of plant cell walls. Although the future of currently available technologies is difficult to predict, a complete and viable platform will most likely be available through the integration of the existing approaches with the development of breakthrough technologies.open8

Zero-frequency Bragg gap by spin-harnessed metamaterial

The Bragg gap that stops wave propagation may not be formed from zero or a very low frequency unless the periodicity of a periodic system is unrealistically large. Accordingly, the Bragg gap has been considered to be inappropriate for low frequency applications despite its broad bandwidth. Here, we report a new mechanism that allows formation of the Bragg gap starting from a nearly zero frequency. The mechanism is based on the finding that if additional spin motion is coupled with the longitudinal motion of a mass of a diatomic mechanical periodic system, the Bragg gap starting from a nearly zero frequency can be formed. The theoretical analysis shows that the effective mass and stiffness at the band gap frequencies are all positive, confirming that the formed stop band is a Bragg gap. The periodic system is realized by a spin-harnessed metamaterial which incorporates unique linkage mechanisms. The numerical and experimental validation confirmed the formation of the low-frequency Bragg gap. The zero-frequency Bragg gap is expected to open a new way to control hard-to-shield low-frequency vibration and noise

Meis Cofactors Control HDAC and CBP Accessibility at Hox-Regulated Promoters during Zebrafish Embryogenesis

SummaryHox proteins form complexes with Pbx and Meis cofactors to control gene expression, but the role of Meis is unclear. We demonstrate that Hoxb1-regulated promoters are highly acetylated on histone H4 (AcH4) and occupied by Hoxb1, Pbx, and Meis in zebrafish tissues where these promoters are active. Inhibition of Meis blocks gene expression and reduces AcH4 levels at these promoters, suggesting a role for Meis in maintaining AcH4. Within Hox transcription complexes, Meis binds directly to Pbx and we find that this binding displaces histone deacetylases (HDACs) from Hoxb1-regulated promoters in zebrafish embryos. Accordingly, Pbx mutants that cannot bind Meis act as repressors by recruiting HDACs and reducing AcH4 levels, while Pbx mutants that bind neither HDAC nor Meis are constitutively active and recruit CBP to increase AcH4 levels. We conclude that Meis acts, at least in part, by controlling access of HDAC and CBP to Hox-regulated promoters