1 research outputs found
Paper-Based Flow Fractionation System Applicable to Preconcentration and Field-Flow Separation
We
present a novel paper-based flow fractionation system for preconcentration
and field-flow separation. In this passive fluidic device, a straight
channel is divided into multiple daughter channels, each of which
is connected with an expanded region. The hydrodynamic resistance
of the straight channel is predominant compared with those of expanded
regions, so we can create steady flows through the straight and daughter
channels. While the expanded regions absorb a great amount of water
via capillarity, the steady flow continues for 10 min without external
pumping devices. By controlling the relative hydrodynamic resistances
of the daughter channels, we successfully divide the flow with flow
rate ratios of up to 30. Combining this bifurcation system with ion
concentration polarization (ICP), we develop a continuous-flow preconcentrator
on a paper platform, which can preconcentrate a fluorescent dye up
to 33-fold. In addition, we construct a field-flow separation system
to divide two different dyes depending on their electric polarities.
Our flow fractionation systems on a paper-based platform would make
a breakthrough for point-of-care diagnostics with specific functions
including preconcentration and separation