The impact of Arctic sea ice loss on mid-Holocene climate.

Mid-Holocene climate was characterized by strong summer solar heating that decreased Arctic sea ice cover. Motivated by recent studies identifying Arctic sea ice loss as a key driver of future climate change, we separate the influences of Arctic sea ice loss on mid-Holocene climate. By performing idealized climate model perturbation experiments, we show that Arctic sea ice loss causes zonally asymmetric surface temperature responses especially in winter: sea ice loss warms North America and the North Pacific, which would otherwise be much colder due to weaker winter insolation. In contrast, over East Asia, sea ice loss slightly decreases the temperature in early winter. These temperature responses are associated with the weakening of mid-high latitude westerlies and polar stratospheric warming. Sea ice loss also weakens the Atlantic meridional overturning circulation, although this weakening signal diminishes after 150-200 years of model integration. These results suggest that mid-Holocene climate changes should be interpreted in terms of both Arctic sea ice cover and insolation forcing

Mid-Holocene Northern Hemisphere warming driven by Arctic amplification.

The Holocene thermal maximum was characterized by strong summer solar heating that substantially increased the summertime temperature relative to preindustrial climate. However, the summer warming was compensated by weaker winter insolation, and the annual mean temperature of the Holocene thermal maximum remains ambiguous. Using multimodel mid-Holocene simulations, we show that the annual mean Northern Hemisphere temperature is strongly correlated with the degree of Arctic amplification and sea ice loss. Additional model experiments show that the summer Arctic sea ice loss persists into winter and increases the mid- and high-latitude temperatures. These results are evaluated against four proxy datasets to verify that the annual mean northern high-latitude temperature during the mid-Holocene was warmer than the preindustrial climate, because of the seasonally rectified temperature increase driven by the Arctic amplification. This study offers a resolution to the "Holocene temperature conundrum", a well-known discrepancy between paleo-proxies and climate model simulations of Holocene thermal maximum

Quantification of The Performance of CMIP6 Models for Dynamic Downscaling in The North Pacific and Northwest Pacific Oceans

Selecting a reliable global climate model as the driving forcing in simulations with dynamic downscaling is critical for obtaining a reliable regional ocean climate. With respect to their accuracy in providing physical quantities and long-term trends, we quantify the performances of 17 models from the Coupled Model Inter-comparison Project Phase 6 (CMIP6) over the North Pacific (NP) and Northwest Pacific (NWP) oceans for 1979–2014. Based on normalized evaluation measures, each model’s performance for a physical quantity is mainly quantified by the performance score (PS), which ranges from 0 to 100. Overall, the CMIP6 models reasonably reproduce the physical quantities of the driving variables and the warming ocean heat content and temperature trends. However, their performances significantly depend on the variables and region analyzed. The EC-Earth-Veg and CNRM-CM6-1 models show the best performances for the NP and NWP oceans, respectively, with the highest PS values of 85.89 and 76.97, respectively. The EC-Earth3 model series are less sensitive to the driving variables in the NP ocean, as reflected in their PS. The model performance is significantly dependent on the driving variables in the NWP ocean. Nevertheless, providing a better physical quantity does not correlate with a better performance for trend. However, MRI-ESM2-0 model shows a high performance for the physical quantity in the NWP ocean with warming trends similar to references, and it could thus be used as an appropriate driving forcing in dynamic downscaling of this ocean. This study provides objective information for studies involving dynamic downscaling of the NP and NWP oceans

Intraspinal Lymphangioma Mimicking Lumbar Disc Herniation

Intraspinal soft tissue lymphangioma is extremely rare and very few cases of intraspinal lymphangioma have been reported. To our knowledge, most reported intraspinal lymphangioma cases manifested only pain or minor neurologic sign. We report here one case of intraspinal lymphangioma which caused profound foot drop. Total removal could be achieved by two microscopic surgeries because of initial misdiagnosis as an organized herniated disc fragment. Six months later, the weakness of her right ankle and big toe was improved to grade 3. There was no evidence of clinical recurrence or aggravation at the final followup visit. If there is an impression suggesting tumorous lesion as in our case, more aggressive evaluation and treatment policy is required to avoid unnecessary further surgery

Inhibition of poly(ADP-ribose)polymerase binding to DNA by thymidine dimer

AbstractThe ability of poly(ADP-ribose)polymerase to bind damaged DNA was assessed by electrophoretic mobility shift assay. DNA binding domain of poly(ADP-ribose)polymerase (PARPDBD) binds to synthetic deoxyribonucleotide duplex 10-mer. However, the synthetic deoxyribonucleotide duplex containing cys-syn thymidine dimer which produces the unwinding of DNA helix structure lost its affinity to PARPDBD. It was shown that the binding of PARPDBD to the synthetic deoxyribonucleotide duplex was not affected by O6-Me-dG which causes only minor distortion of DNA helix structure. This study suggests that the stabilized DNA helix structure is important for poly(ADP-ribose)polymerase binding to DNA breaks, which are known to stimulate catalytic activity of poly(ADP-ribose)polymerase