Source Characteristics of Atmospheric CO(2)and CH(4)in a Northeastern Highland Area of South Korea

This study aims to present the atmospheric CO(2)and CH(4)levels and analyze their source characteristics at an observation station in a northeastern highland area of Korea for the 2012-2014 period. We summarized the measured CO(2)and CH(4)concentrations for the 2012-2014 period. In addition, we characterized the major source of the rise of CO(2)and CH(4)in Ganseong (GS) by employing bivariate polar plots (BPP) and the concentration weighted trajectory (CWT) method together with currently available information on emission sources. For the three years, CO(2)was generally high in the order of winter, spring, autumn and summer and CH(4)high in the order of winter, autumn, spring and summer. The observed positive correlations between the hourly CO(2)and CH(4)in every season suggested the possibility of shared common emission sources, but there is a necessity for elucidation on this in the future. The BPP analysis indicated the local sources that are likely to be associated with the rise of greenhouse gases (GHGs) observed at GS (combustion in the village, plant respirations nearby GS, and mobile emissions on the nearby road for CO(2)and leakages from the gas stations along the road and agricultural activities for CH4). Synthesizing the CWT results together with emission source information from national and global emission inventories, we identified likely major source areas and characterized major emission sources. For example, the identified major sources for the winter CO(2)are coal combustion, coal washing and industrial activities in Inner Mongolia, northern and the northeastern China, fuel burning for the energy for the infrastructure of a northwestern city in South Korea, and the manufacturing industry and fuel combustion in the northern parts of North Korea. Hopefully, these kinds of results will aid environmental researchers and decision-makers in performing more in-depth studies for GHG sources in order to derive effective mitigation strategies

Synthesis of Heterograft Copolymers with a Semifluorinated Backbone by Combination of Grafting-through and Graftingfrom Polymerizations

International audienceWe report that an alternating semifluorinated copolymer of chlorotrifluoroethylene (CTFE) and vinyl ether (VE) is an attractive platform for the synthesis of heterograft copolymers consisting of two distinct side chains. The radical terpolymerization of CTFE with PLA-tethered vinyl ether (PLAVE) synthesized by ring-opening polymerization and isobutyl vinyl ether (IBVE) as a spacer produced PLA-grafted fluorinated copolymer via a “grafting-through” manner. Two PLAVEs with different molar masses (2 and 10 kg mol–1) were successfully incorporated, and the grafting density could be controlled by varying the [PLAVE]/[IBVE] initial molar ratio. From the chlorine atoms in the CTFE repeating units, atom transfer radical polymerization (ATRP) of styrene was further employed to grow PS side chains following a “grafting-from” mechanism per each (CTFE-alt-VE) repeating unit dyad. First-order kinetics was observed for the styrene polymerization and supported controlled growth of PS. The resulting heterograft copolymers possessed regularly spaced PS chains and statistically distributed PLA chains on the backbone, generating a nanoscopic disordered morphology via microphase separation driven by incompatibility between PLA and PS. By copolymerization of styrene and divinylbenzene (DVB) in neat ATRP condition, a cross-linked polymer monolith with the disordered bicontinuous morphology could be also prepared via polymerization-induced microphase separation. The cross-linked precursor was converted into a mesoporous polymer with pore size of 3.7–10.4 nm by removal of PLA. The mesopore size was tunable by adjusting the PLA molar mass and styrene/DVB molar ratio

Apigenin’s Therapeutic Potential Against Viral Infection

Several antiviral drugs are clinically approved to treat influenza that is a highly prevalent acute respiratory disease. However, emerging drug-resistant virus strains undermine treatment efficacy, highlighting the exigency for novel antiviral drugs to counter these drug-resistant strains. Plants and their derivates have been historically utilized as medicinal remedies, and extensive studies have evidenced the antiviral potential of phytochemicals. Notably, apigenin is a predominant flavonoid with minimal toxicity and substantial therapeutic effects in various disease models. Despite its many anti-inflammatory, anti-oxidant, anti-cancer, anti-bacterial, and other beneficial bioactivities, existing reviews have yet to focus on apigenin’s antiviral effects. Therefore, this review elucidates apigenin’s therapeutic and antiviral properties in vitro and in vivo, discussing its mode of action and future prospects. Apigenin’s remarkable inhibition by modulating multiple mechanisms against viruses has promising potential for novel plant-derived antiviral drugs and further clinical study developments

Uncertainty of Rate of Change in Korean Future Rainfall Extremes Using Non-Stationary GEV Model

Interest in future rainfall extremes is increasing, but the lack of consistency in the future rainfall extremes outputs simulated in climate models increases the difficulty of establishing climate change adaptation measures for floods. In this study, a methodology is proposed to investigate future rainfall extremes using future surface air temperature (SAT) or dew point temperature (DPT). The non-stationarity of rainfall extremes is reflected through non-stationary frequency analysis using SAT or DPT as a co-variate. Among the parameters of generalized extreme value (GEV) distribution, the scale parameter is applied as a function of co-variate. Future daily rainfall extremes are projected from 16 future SAT and DPT ensembles obtained from two global climate models, four regional climate models, and two representative concentration pathway climate change scenarios. Compared with using only future rainfall data, it turns out that the proposed method using future temperature data can reduce the uncertainty of future rainfall extremes outputs if the value of the reference co-variate is properly set. In addition, the confidence interval of the rate of change of future rainfall extremes is quantified using the posterior distribution of the parameters of the GEV distribution sampled using Bayesian inference

Estimation of Real-Time Rainfall Fields Reflecting the Mountain Effect of Rainfall Explained by the WRF Rainfall Fields

The effect of mountainous regions with high elevation on hourly timescale rainfall presents great difficulties in flood forecasting and warning in mountainous areas. In this study, the hourly rainfall–elevation relationship of the regional scale is investigated using the hourly rainfall fields of three storm events simulated by Weather Research and Forecasting (WRF) model. From this relationship, a parameterized model that can estimate the spatial rainfall field in real time using the hourly rainfall observation data of the ground observation network is proposed. The parameters of the proposed model are estimated using eight representative pixel pairs in valleys and mountains. The proposed model was applied to the Namgang Dam watershed, a representative mountainous region in the Korea, and it was found that as elevation increased in eight selected pixel pairs, rainfall intensity also increased. The increase in rainfall due to the mountain effect was clearly observed with more rainfall in high mountainous areas, and the rainfall distribution was more realistically represented using an algorithm that tracked elevation along the terrain. The proposed model was validated using leave-one-out cross-validation with seven rainfall observation sites in mountainous areas, and it demonstrated clear advantages in estimating a spatial rainfall field that reflects the mountain effect. These results are expected to be helpful for flood forecasting and warning, which need to be calculated quickly, in mountainous areas. Considering the importance of orographic effects on rainfall spatial distribution in mountainous areas, more storm events and physical analysis of environmental factors (wind direction, thermal cycles, and mountain slope angle) should be continuously studied

Low-Molecular-Weight β-1,3-1,6-Glucan Derived from <i>Aureobasidium pullulans</i> Exhibits Anticancer Activity by Inducing Apoptosis in Colorectal Cancer Cells

β-glucan, a plant polysaccharide, mainly exists in plant cell walls of oats, barley, and wheat. It is attracting attention due to its high potential for use as functional foods and pharmaceuticals. We have previously reported that low-molecular-weight Aureobasidium pullulans-fermented β-D-glucan (LMW-AP-FBG) could inhibit inflammatory responses by inhibiting mitogen-activated protein kinases and nuclear factor-κB signaling pathways. Bases on previous results, the objective of the present study was to investigate the therapeutic potential of LMW-AP-FBG in BALB/c mice intracutaneously transplanted with CT-26 colon cancer cells onto their backs. Daily intraperitoneal injections of LMW-AP-FBG (5 mg/kg) for two weeks significantly suppressed tumor growth in mice bearing CT-26 tumors by reducing tumor proliferation and inducing apoptosis as compared to phosphate buffer-treated control mice. In addition, LMW-AP-FBG treatment reduced the viability of CT-26 cells in a dose-dependent manner by inducing apoptosis with loss of mitochondrial transmembrane potential and increased activated caspases. Taken together, LMW-AP-FBG exhibits anticancer properties both in vivo and in vitro

Grain Size and Phase Transformation Behavior of TiNi Shape-Memory-Alloy Thin Film under Different Deposition Conditions

TiNi shape-memory-alloy thin films can be used as small high-speed actuators or sensors because they exhibit a rapid response rate. In recent years, the transformation temperature of these films, manufactured via a magnetron sputtering method, was found to be lower than that of the bulk alloys owing to the small size of the grain. In this study, deposition conditions (growth rate, film thickness, and substrate temperature) affecting the grain size of thin films were investigated. The grain size of the thin film alloys was found to be most responsive to the substrate temperature

Development of in vitro osteoporosis model in minipig proximal humerus and femur: validation in histological and biomechanical study

Abstract Background The minipig has been used for research in various fields of medicine, even in orthopedics. Though previous studies have already suggested other methods to create osteoporotic bone, those methods had some disadvantages for taking time and efforts. Therefore, we aimed to generate osteoporotic proximal humerus and proximal femur of minipig using EDTA solution and validate their properties through dual energy X-ray absorptiometry (DEXA), micro-CT study, histological and biomechanical ways. Methods Six minipigs were used. Out of a total of 12 proximal humerus (PH) and 12 proximal femurs (PF), 6 PH and 6 PF were used as the decalcified group and the opposite side as the non-decalcified group. In vitro decalcification with Ca-chelating agents (0.5 M EDTA solution, pH 7.4) was used. Area BMD (aBMD) was measured using DEXA, Volumetric BMD (vBMD), and microstructure were measured using micro-CT. Universal testing machine was used to measure ultimate load to failure (ULTF). Each group was compared using two types of suture anchors (all-suture anchor, ASA, and conventional screw type anchor, CA). Results There was a significant difference in aBMD and cortical thickness (aBMD: decalcified, 0.433 ± 0.073 g/cm2, undecalcified, 0.962 ± 0.123 g/cm2, p < 0.001; cortical thickness: decalcified, 0.33 ± 0.34 mm, undecalcified, 1.61 ± 0.45 mm, p < 0.001). In the case of ASA, the ULTF was significantly lower in the decalcified group (decalcified: 176.6 ± 74.2 N, non-decalcified: 307.7 ± 116.5 N, p = 0.003). In the case of CA, there was no significant difference (decalcified: 265.1 ± 96.0 N, undecalcified: 289.4 ± 114.5 N, p = 0.578). Conclusion We demonstrated that decalcification with EDTA solution significantly decreased aBMD, vBMD, and cortical thickness. Decalcified minipig bone using EDTA resulted in similar biomechanical properties as osteoporotic human bone with respect to anchor pull-out

Strategic design of gold nanocatalysts for effective photocatalytic organic transformation

We demonstrate the design strategy of free-standing Au nanocatalysts by correlating their physicochemical characteristics with photocatalytic performance. By tailoring the particle size and surface characteristics, we found that small Au nanocatalysts called Au nanoclusters with discrete energy levels are more effective than large metallic Au nanoparticles, while the microenvironments (e.g., charge status and hydrophilicity/hydrophobicity) around the surface of Au-nanoclusters are crucial in determining the performance. With the optimized Au nanocatalyst, under visible light, decarboxylative radical addition reactions for C-C bond formation (i.e., Giese reaction) were first achieved with high yields and further utilized for the preparation of one of the bioactive γ-aminobutyric acid derivatives, pregabalin (Lyrica®), demonstrating its potential in pharmaceutical applications. © 2023 The Royal Society of Chemistry11Nsciescopu