7 research outputs found
Electron microscopic pathological patterns of alveolar septum in acute dextran-induced and alloxan-induced pulmonary edema in dogs
We studied the incidence of electron
microscopic pathological patterns of the alveolar septum
observed 30 min after induction of pulrnonary edema by
dextran-70 infusion (6 dogs, dextran group) and by
alloxan injection (6 dogs, alloxan group).
For comparable amounts of extravascular lung water
in both dextran and alloxan groups, which were twice as
much as control group (6 dogs), we characterized the
pathological changes.
The incidence of the electron microscopic
pathological patterns that appeared in dextran group
compared with that in control group was significantly
high in terms of the widening of the interstitial space.
dispersion and disarray of collagen fibrils, and
erythrocytes in the interstitial space. The incidence in
alloxan group compared with that in control group was
significantly high in terms of the swelling of epithelial
cells and endothelial cells as well as the widening of the
interstitial space, and dispersion and disarray of collagen
fibrils.
We conclude that dextran causes interstitial changes
exclusively and alloxan causes cellular changes primarily
coupled with secondary interstitial changes in acute
pulmonary edema