Formation of the binary pulsars PSR B2303+46 and PSR J1141-6545 - young neutron stars with old white dwarf companions

We have investigated the formation of the binary radio pulsars PSR B2303+46 and PSR J1141-6545 via Monte Carlo simulations of a large number of interacting stars in binary systems. PSR B2303+46 has recently been shown (van Kerkwijk & Kulkarni 1999) to be the first neutron star - white dwarf binary system observed, in which the neutron star was born after the formation of the white dwarf. We discuss the formation process for such a system and are able to put constraints on the parameters of the initial ZAMS binary. We present statistical evidence in favor of a white dwarf companion to the binary pulsar PSR J1141-6545, just recently discovered in the Parkes Multibeam Survey. If this is confirmed by observations this system will be the second one known in which the neutron star was born after its white dwarf companion. We also predict a minimum space velocity of 150 km/s for PSR J1141-6545, and show it must have experienced an asymmetric SN in order to explain its low eccentricity. Finally, we estimate the birthrate of these systems relative to other binary pulsar systems and present the expected distribution of their orbital periods, eccentricities and velocities.Comment: 9 pages, 4 figures, 2 tables, some revisions, accepted for publication in A&A Main Journa

Improved results in proteomics by use of local and peptide-class specific false discovery rates

<p>Abstract</p> <p>Background</p> <p>Proteomic protein identification results need to be compared across laboratories and platforms, and thus a reliable method is needed to estimate false discovery rates. The target-decoy strategy is a platform-independent and thus a prime candidate for standardized reporting of data. In its current usage based on global population parameters, the method does not utilize individual peptide scores optimally.</p> <p>Results</p> <p>Here we show that proteomic analyses largely benefit from using separate treatment of peptides matching to proteins alone or in groups based on locally estimated false discovery rates. Our implementation reduces the number of false positives and simultaneously increases the number of proteins identified. Importantly, single peptide identifications achieve defined confidence and the sequence coverage of proteins is optimized. As a result, we improve the number of proteins identified in a human serum analysis by 58% without compromising identification confidence.</p> <p>Conclusion</p> <p>We show that proteins can reliably be identified with a single peptide and the sequence coverage for multi-peptide proteins can be increased when using an improved estimation of false discovery rates.</p

Diurnal Variation of Markers for Cholesterol Synthesis, Cholesterol Absorption, and Bile Acid Synthesis:A Systematic Review and the Bispebjerg Study of Diurnal Variations

Human studies have shown diurnal rhythms of cholesterol and bile acid synthesis, but a better understanding of the role of the circadian system in cholesterol homeostasis is needed for the development of targeted interventions to improve metabolic health. Therefore, we performed a systematic literature search on the diurnal rhythms of cholesterol synthesis and absorption markers and of bile acid synthesis markers. We also examined the diurnal rhythms of the cholesterol synthesis markers lathosterol and desmosterol, and of the cholesterol absorption markers cholestanol, campesterol, and sitosterol in serum samples from the Bispebjerg study. These samples were collected every three hours over a 24-h period in healthy males (n = 24) who consumed low-fat meals. The systematic search identified sixteen papers that had examined the diurnal rhythms of the cholesterol synthesis markers lathosterol (n = 3), mevalonate (n = 9), squalene (n = 2), or the bile acid synthesis marker 7 alpha-hydroxy-4-cholesten-3-one (C4) (n = 4). Results showed that lathosterol, mevalonate, and squalene had a diurnal rhythm with nocturnal peaks, while C4 had a diurnal rhythm with daytime peaks. Furthermore, cosinor analyses of the serum samples showed a significant diurnal rhythm for lathosterol (cosinor p 0.05). In conclusion, cholesterol synthesis and bile acid synthesis have a diurnal rhythm, though no evidence for a diurnal rhythm of cholesterol absorption was found under highly standardised conditions. More work is needed to further explore the influence of external factors on the diurnal rhythms regulating cholesterol homeostasis

Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ

CryoET shows the configuration of the ephemeral translationally inactive 100S ribosomal dimer