A Multi-Classification Method of Improved SVM-based Information Fusion for Traffic Parameters Forecasting

With the enrichment of perception method, modern transportation system has many physical objects whose states are influenced by many information factors so that it is a typical Cyber-Physical System (CPS). Thus, the traffic information is generally multi-sourced, heterogeneous and hierarchical. Existing research results show that the multi-sourced traffic information through accurately classifying in the process of information fusion can achieve better parameters forecasting performance. For solving the problem of traffic information accurately classification, via analyzing the characteristics of the multi-sourced traffic information and using redefined binary tree to overcome the shortcomings of the original SVM (Support Vector Machine) classification in information fusion, a multi-classification method using improved SVM in information fusion for traffic parameters forecasting is proposed. The experiment was conducted to examine the performance of the proposed scheme and the results reveal that the method can get more accurate and practical outcomes.  </p

The double Burgers model of fractured rock masses considering creep fracture damage

Creep fracture of rock cracks is responsible for the creep failure of fractured rock masses. To capture creep fracture behaviors of fractured rock, we investigated the time-dependent characteristics of the rock crack propagation. The theoretical analysis shows that, similar to the rock creep process, the creep fracture of rock cracks includes the attenuation and steady creep stages. In addition, we established an equivalent Burgers model for creep fracture of rock cracks by introducing the equivalent stress and proposed a double Burgers model to study creep behaviors of fractured rock masses. Moreover, the proposed double Burgers model was embedding into FLAC3D, using FISH function. The numerical simulations on the specimens, containing ordered and random cracks, show that the creep fracture is responsible for the creep damage of fractured rock masses; moreover, the lateral creep damage is larger than the axial creep damage

Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai

<p>Abstract</p> <p>Background</p> <p>Pathogenic <it>Leptospira </it>species cause leptospirosis, a zoonotic disease of global importance. The spirochete displays active rotative mobility which may contribute to invasion and diffusion of the pathogen in hosts. FliY is a flagellar motor switch protein that controls flagellar motor direction in other microbes, but its role in <it>Leptospira</it>, and paricularly in pathogenicity remains unknown.</p> <p>Results</p> <p>A suicide plasmid for the <it>fliY </it>gene of <it>Leptospira interrogans </it>serogroup Icterohaemorrhagiae serovar Lai strain Lai that was disrupted by inserting the ampicillin resistance gene (<it>bla</it>) was constructed, and the inactivation of <it>fliY </it>gene in a mutant (<it>fliY</it>^-) was confirmed by PCR and Western Blot analysis. The inactivation resulted in the mRNA absence of <it>fliP </it>and <it>fliQ </it>genes which are located downstream of the <it>fliY </it>gene in the same operon. The mutant displayed visibly weakened rotative motion in liquid medium and its migration on semisolid medium was also markedly attenuated compared to the wild-type strain. Compared to the wild-type strain, the mutant showed much lower levels of adhesion to murine macrophages and apoptosis-inducing ability, and its lethality to guinea pigs was also significantly decreased.</p> <p>Conclusion</p> <p>Inactivation of <it>fliY</it>, by the method used in this paper, clearly had polar effects on downstream genes. The phentotypes observed, including lower pathogenicity, could be a consequence of <it>fliY </it>inactivation, but also a consequence of the polar effects.</p

Eyes grow towards mild hyperopia rather than emmetropia in Chinese preschool children

Purpose: To document one-year changes in refraction and refractive components in preschool children. Methods: Children, 3–5 years old, in the Jiading District, Shanghai, were followed for one year. At each visit, axial length (AL), refraction under cycloplegia (1% cyclopentolate), spherical dioptres (DS), cylinder dioptres (DC), spherical equivalent refraction (SER) and corneal curvature radius (CR) were measured. Results: The study included 458 right eyes of 458 children. The mean changes in DS, DC and SER were 0.02 ± 0.35 D, −0.02 ± 0.33 D and 0.01 ± 0.37 D, while the mean changes in AL, CR and lens power (LP) were 0.27 ± 0.10 mm, 0.00 ± 0.04 mm and − 0.93 ± 0.49 D. The change in the SER was linearly correlated with the baseline SER (coefficient = −0.147, p < 0.001). When the baseline SER was at 1.05 D (95% CI = 0.21 to 2.16), the change in SER was 0 D. The baseline SER was also linearly associated with the change in LP (coefficient = 0.104, p = 0.013), but not with the change in AL (p = 0.957) or with the change in CR (p = 0.263). Conclusion: In eyes with a baseline SER less than +1.00 D, LP loss was higher compared to axial elongation, leading to hyperopic shifts in refraction, whereas for those with baseline SER over this range, loss of LP compared to axial elongation was reduced, leading to myopic shifts. This model indicated the homeostasis of human refraction and explained how refractive development leads to a preferred state of mild hyperopia.The study was funded by Chinese National NatureScience Foundation (No. 81670898), Chinese Nat-ural Science Foundation for Young Staff (No.81800881), The Shanghai Three Year Public HealthAction Program (No. GWIV-3.3), The ShanghaiHigh-level Oversea Training Team Program on EyePublic Health (No. GWTD2015S08), The ShanghaiOutstanding Academic Leader Program (No.16XD1402300), Shanghai Nature Science Founda-tion (NO. 15ZR1438400), Three-year Action Pro-gram of Shanghai Municipality for Strengtheningthe Construction of the Public Health System(NO.GWIV-13.2), Key Discipline of PublicHealth-Eye health in Shanghai (No.15GWZK0601), Municipal Human ResourcesDevelopment Program for Outstanding YoungTalents in Medical and Health Sciences in Shanghai(Grant No. 2017YQ019), Shanghai Sailing Program(No. 17YF1416100), Foundation of ShanghaiMunicipal Commission of Health and FamilyPlanning (No. 20184Y0217), National Key R&DProgramofChina(2016YFC0904800,2019YFC0840607), National Science and Technol-ogy Major Project of China (2017ZX09304010) andSongjiang Science Foundation (No. 19SJKJGG30)

Mapping of spatiotemporal auricular electrophysiological signals reveals human biometric clusters

Underneath the ear skin there are rich vascular network and sensory nerve branches. Hence, the 3D mapping of auricular electrophysiological signals can provide new biomedical perspectives. However, it is still extremely challenging for current sensing techniques to cover the entire ultra-curved auricle. Here, a 3D graphene-based ear-conformable sensing device with embedded and distributed 3D electrodes for full-auricle physiological monitoring is reported. As a proof-of-concept, spatiotemporal auricular electrical skin resistance (AESR) mapping is demonstrated for the first time, and human subject-specific AESR distributions are observed. From the data of more than 30 ears (both right and left ears), the auricular region-specific AESR changes after cycling exercise are observed in 98% of the tests and are clustered into four groups via machine learning-based data analyses. Correlations of AESR with heart rate and blood pressure are also studied. This 3D electronic platform and AESR-based biometrical findings show promising biomedical applications