19 research outputs found

    Population pharmacokinetics of tacrolimus in whole blood and plasma in Asian liver transplant patients

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    10.2165/00003088-200645010-00004Clinical Pharmacokinetics45159-7

    Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

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    Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA
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