Measurement and correlation of helium and fluid leak rates

Measurement and correlation of helium and fluid leak rates in Apollo propellants and ECS fluid

The synthesis of potential antimalarials. Derivatives of pantoyltaurine

The general hypothesis as to the mode of action of chemotherapeutic agents, which has been formulated by Fildes, Woods, McIlwain, and others (2), offers a rational and useful guide to the design of new drugs. Thus, bacteriostasis is pictured as caused by the blocking of reactions essential to growth by an inhibiting substance which has a structure similar to that of one of the normal enzymes or metabolites essential to the growth of the organism

The synthesis of potential antimalarials; derivatives of α, γ-dihydroxy-β, β-dimethyl-N-ethylbutyramide

In 1943 it became known (1) that pantoyltaurylamide (SN 3279) showed antimalarial activity when administered intravenously to chicks infected with Plasmodium gallinaceum. When subsequently phenyl pantothenone (I) (SN 12610), prepared by Woolley and Collyer (2), was tested and shown to possess activity when given orally, it was decided to examine compounds which might be regarded as sulfur analogues of I. Accordingly l-pantolactone was condensed with a series of amines to give the five derivatives of butyramide II to VI