Understanding the Context of Global Health Policies: Their Post-Colonial

The systemic inadequacies of models of health systems propagated by the advocates of global health policies (GHPs) have fragmented health service systems, particularly in middle- and lower-income countries. GHPs are underpinned by economic interests and the need for control by the global elite, irrespective of people’s health needs. The COVID-19 pandemic challenged the advocates of GHPs, leading to calls for a movement for “decolonisation” of global health. Much of this narrative on the “decolonisation” of GHPs critiques its northern knowledge base, and the power derived from it at individual, institutional and national levels. This, it argues, has led to an unequal exchange of knowledge, making it impossible to end decades of oppressive hegemony and to prevent inappropriate decision-making on GHPs. Despite these legitimate concerns, little in the literature on the decolonisation of GHPs extends beyond epistemological critiques. This article offers a radically different perspective. It is based on an understanding of the role of transnational capital in extracting wealth from the economies of low- and middle-income countries resulting in influencing and shaping public health policy and practice, including interactions between the environment and health. It mobilises historical evidence of distorted priorities underpinning GHPs and the damaging consequences for health services throughout the world

Antigen-Independent IFN-γ Production by Human Naïve CD4+ T Cells Activated by IL-12 Plus IL-18

The role of T cells in innate immunity is not well defined. In this report, we show that a subset of human peripheral blood CD4+ T cells responds to IL-12 plus IL-18, but not to IL-12 or IL-18 alone, by producing IFN-γ in the absence of any antigenic stimulation or cell proliferation. Intracellular staining reveals a small percentage of resting CD4+ T cells (0.5 to 1.5%) capable of producing IFN-γ in response to IL-12 plus IL-18. Interestingly, both naïve (CD45RA+) and memory (CD45RO+) CD4+ populations were responsive to IL-12 plus IL-18 stimulation in producing IFN-γ. The expression of IFN-γinduced by IL-12 and IL-18 is sensitive to rapamycin and SB203580, indicating the possible involvement of mTOR and p38 MAP kinase, respectively, in this synergistic pathway. While p38MAP kinase is involved in transcription, mTOR is involved in message stabilization. We have also shown that NFκB family member, cRel, but not GADD45β and GADD45γ, plays an important role in IL-12 plus IL-18-induced IFN-γ transcription. Thus, the present study suggests that naïve CD4+ T cells may participate in innate immunity or amplify adaptive immune responses through cytokine-induced antigen-independent cytokine production

Syria Neoliberal Reforms in Health Sector Financing: Embedding Unequal Access?

The recent volatility and uprisings in several countries of the Arab world have been interpreted by the West solely as a popular demand for political voice. However, in all the countries of the region, including those in which there is ongoing violent opposition, the underlying economic dysfunction speaks for itself. The legacy of joblessness, food riots, and hunger is commonplace and is most often related to structural reforms and austerity measures promoted by the IMF and World Bank. These have played a significant role in reinforcing the rich-poor divide over the past three decades, fostering inequality, suffering, social divisions, and discontent, which are often overlooked by Western observers. In Syria, the state introduced policies for the liberalization of the economy as early as 2000; these were formalized into the 10th Five-Year Plan (2006-2010). Economic liberalization has been supported by the European Union with technical support from the German Technical Cooperation agency (GTZ). Changes made to the health sector and the labor market include: the piloting of health insurance schemes to replace universal coverage, the charging of fees for health services in public hospitals, and job losses across the board. While the West views discontent in Syria largely as political, its own role in promoting economic reforms and social hardship has been largely missed. In large part, discontent in Syria and in the region as a whole are a part of a phenomenon that has repeatedly highlighted the failure of policies that aim at rapid commercialization with little consideration for pre-existing disparities in wealth and resources. This paper traces some of the proposed changes to the financing of health care and examines the implications for access and equity. re and examines teh implications for access and equity

Can Lebanon conjure a public health phoenix from the ashes?

The recent bombing of Lebanon has destroyed much of the health infrastructure. The challenge now is to establish a focus on primary care and public health service

The health systems funding platform and World Bank legacy: the gap between rhetoric and reality

Global health partnerships created to encourage funding efficiencies need to be approached with some caution, with claims for innovation and responsiveness to development needs based on untested assumptions around the potential of some partners to adapt their application, funding and evaluation procedures within these new structures. We examine this in the case of the Health Systems Funding Platform, which despite being set up some three years earlier, has stalled at the point of implementation of its key elements of collaboration. While much of the attention has been centred on the suspension of the Global Fund’s Round 11, and what this might mean for health systems strengthening and the Platform more broadly, we argue that inadequate scrutiny has been made of the World Bank’s contribution to this partnership, which might have been reasonably anticipated based on an historical analysis of development perspectives. Given the tensions being created by the apparent vulnerability of the health systems strengthening agenda, and the increasing rhetoric around the need for greater harmonization in development assistance, an examination of the positioning of the World Bank in this context is vital

A new faunistic component of the Lower Triassic Panchet Formation of India increases the continental non-archosauromorph neodiapsid record in the aftermath of the end-Permian mass extinction

The fossil record of Early Triassic diapsids is very important to understand how the end-Permian mass extinction affected ecosystems and the patterns and processes involved in the subsequent biotic recovery. Vertebrate fossil assemblages of continental deposits in current-day South Africa, China, and Russia are the best source of information of this clade during the aftermath of the extinction event. Although considerably less sampled, the Induan continental rocks of the Panchet Formation of the Damodar Basin (eastern India) have also yielded a relatively diverse vertebrate assemblage composed of fishes, temnospondyls, synapsids, and a single proterosuchid taxon. Here, we report on a small isolated diapsid partial ilium (ISIR 1132) from the upper Panchet Formation. This specimen has a distinct morphology compared to other tetrapods that we know, including a shallow emargination on the dorsal margin of the anterior portion of the iliac blade, and ratio between height of iliac blade versus maximum height of iliac acetabulum at level of the dorsalmost extension of supraacetabular crest ≤0.45. Comparisons and a quantitative phylogenetic analysis found ISIR 1132 as a non-archosauromorph neodiapsid. This new specimen expands the reptile diversity in the Panchet Formation as well as for the rest of Gondwana, where Early Triassic non-archosauromorph neodiapsid species are extremely scarce.Fil: Ezcurra, Martin Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Bandyopadhyay, Saswati. Indian Statistical Institute; IndiaFil: Sen, Kasturi. Indian Statistical Institute; Indi