Correction to: Spatially resolved multiomics of human cardiac niches (Nature, (2023), 619, 7971, (801-810), 10.1038/s41586-023-06311-1)

\ua9 The Author(s) 2025.Correction to: Nature https://doi.org/10.1038/s41586-023-06311-1 Published online 12 July 2023. In the drug2cell analysis of the initially published article, there was an error in filtering drug and target interactions. The activity (pChEMBL) threshold for these interactions was specifically set for each family of target molecules in accordance with the Illuminating the Druggable Genome (IDG) project. In the original manuscript, there was a discrepancy with the values from the IDG project1. We have now updated the threshold values (“Kinases”: revised from ≤1 μM to ≤30 nM; “GPCRs”: unchanged; “Nuclear hormone receptors”: unchanged; “Ion channels”: unchanged; “others”: revised from ≤30 nM to ≤1 μM) in both the analysis reported here and the drug2cell package (https://github.com/Teichlab/drug2cell, version 0.1.2). The main Fig. 4b, Supplementary Table 9 and the relevant section in Methods (“Drug2cell”) have been revised accordingly. In Fig. 4b, two drugs, irbesartan and zopiclone, have been removed from the original figure due to changes in their target molecules. The main text is unaffected and therefore unchanged

Single-cell integration reveals metaplasia in inflammatory gut diseases

\ua9 The Author(s) 2024.The gastrointestinal tract is a multi-organ system crucial for efficient nutrient uptake and barrier immunity. Advances in genomics and a surge in gastrointestinal diseases1,2 has fuelled efforts to catalogue cells constituting gastrointestinal tissues in health and disease3. Here we present systematic integration of 25 single-cell RNA sequencing datasets spanning the entire healthy gastrointestinal tract in development and in adulthood. We uniformly processed 385 samples from 189 healthy controls using a newly developed automated quality control approach (scAutoQC), leading to a healthy reference atlas with approximately 1.1 million cells and 136 fine-grained cell states. We anchor 12 gastrointestinal disease datasets spanning gastrointestinal cancers, coeliac disease, ulcerative colitis and Crohn’s disease to this reference. Utilizing this 1.6 million cell resource (gutcellatlas.org), we discover epithelial cell metaplasia originating from stem cells in intestinal inflammatory diseases with transcriptional similarity to cells found in pyloric and Brunner’s glands. Although previously linked to mucosal healing4, we now implicate pyloric gland metaplastic cells in inflammation through recruitment of immune cells including T cells and neutrophils. Overall, we describe inflammation-induced changes in stem cells that alter mucosal tissue architecture and promote further inflammation, a concept applicable to other tissues and diseases