Collisions of self-bound quantum droplets

We report on the study of binary collisions between quantum droplets formed by an attractive mixture of ultracold atoms. We distinguish two main outcomes of the collision, i.e. merging and separation, depending on the velocity of the colliding pair. The critical velocity $v_c$ that discriminates between the two cases displays a different dependence on the atom number $N$ for small and large droplets. By comparing our experimental results with numerical simulations, we show that the non-monotonic behavior of $v_c(N)$ is due to the crossover from a compressible to an incompressible regime, where the collisional dynamics is governed by different energy scales, i.e. the droplet binding energy and the surface tension. These results also provide the first evidence of the liquid-like nature of quantum droplets in the large $N$ limit, where their behavior closely resembles that of classical liquid droplets

Potent Anti-Cancer Properties of Phthalimide-Based Curcumin Derivatives on Prostate Tumor Cells

Metastatic castration-resistant prostate cancer is commonly treated with chemotherapy, whose effect is less than satisfactory. This raised the need for novel agents for the treatment of prostate cancer. In the present study, five phthalimide-based curcumin derivatives were synthesized and completely characterized to assess improved stability, pharmacodynamics, and radical scavenging ability. To investigate the potential application in anti-cancer therapy, the anti-proliferative activity of the synthesized molecules was determined on aggressive prostate tumor cells. We demonstrated that the K3F21 derivative has increased potency compared to curcumin, in terms of GI50, anti-proliferative and anti-migrating activities. K3F21 inhibits anchorage-dependent and -independent growth of prostate cancer cells by altering the expression of key genes controlling cell proliferation, such as Cylins D1, B1 and B2, and apoptosis, among which Puma, Noxa, and Bcl-2 family members. Finally, the anti-cancer activity of K3F21 was demonstrated by the analysis of cancer-associated PI3K/AKT, ERK, and p38 signaling pathways

Universality of the three-body Efimov parameter at narrow Feshbach resonances

We measure the critical scattering length for the appearance of the first three-body bound state, or Efimov three-body parameter, at seven different Feshbach resonances in ultracold 39K atoms. We study both intermediate and narrow resonances, where the three-body spectrum is expected to be determined by the non-universal coupling of two scattering channels. We observe instead approximately the same universal relation of the three-body parameter with the two-body van der Waals radius already found for broader resonances, which can be modeled with a single channel. This unexpected observation suggests the presence of a new regime for three-body scattering at narrow resonances

Enhancing Detection of Topological Order by Local Error Correction

The exploration of topologically-ordered states of matter is a long-standing goal at the interface of several subfields of the physical sciences. Such states feature intriguing physical properties such as long-range entanglement, emergent gauge fields and non-local correlations, and can aid in realization of scalable fault-tolerant quantum computation. However, these same features also make creation, detection, and characterization of topologically-ordered states particularly challenging. Motivated by recent experimental demonstrations, we introduce a new paradigm for quantifying topological states -- locally error-corrected decoration (LED) -- by combining methods of error correction with ideas of renormalization-group flow. Our approach allows for efficient and robust identification of topological order, and is applicable in the presence of incoherent noise sources, making it particularly suitable for realistic experiments. We demonstrate the power of LED using numerical simulations of the toric code under a variety of perturbations. We subsequently apply it to an experimental realization, providing new insights into a quantum spin liquid created on a Rydberg-atom simulator. Finally, we extend LED to generic topological phases, including those with non-abelian order.Comment: Corrected minor typos. Added new results on generalizations to non-abelian topological phases, and connections between LED and topological entanglement negativit

A quantum processor based on coherent transport of entangled atom arrays

The ability to engineer parallel, programmable operations between desired qubits within a quantum processor is central for building scalable quantum information systems. In most state-of-the-art approaches, qubits interact locally, constrained by the connectivity associated with their fixed spatial layout. Here, we demonstrate a quantum processor with dynamic, nonlocal connectivity, in which entangled qubits are coherently transported in a highly parallel manner across two spatial dimensions, in between layers of single- and two-qubit operations. Our approach makes use of neutral atom arrays trapped and transported by optical tweezers; hyperfine states are used for robust quantum information storage, and excitation into Rydberg states is used for entanglement generation. We use this architecture to realize programmable generation of entangled graph states such as cluster states and a 7-qubit Steane code state. Furthermore, we shuttle entangled ancilla arrays to realize a surface code with 19 qubits and a toric code state on a torus with 24 qubits. Finally, we use this architecture to realize a hybrid analog-digital evolution and employ it for measuring entanglement entropy in quantum simulations, experimentally observing non-monotonic entanglement dynamics associated with quantum many-body scars. Realizing a long-standing goal, these results pave the way toward scalable quantum processing and enable new applications ranging from simulation to metrology.Comment: 23 pages, 14 figures; movie attached as ancillary fil

Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients

Approaches based on expression signatures of prostate cancer (PCa) have been proposed to predict patient outcomes and response to treatments. The transcription factor NF-Y participates to the progression from benign epithelium to both localized and metastatic PCa and is associated with aggressive transcriptional profile. The gene encoding for NF-YA, the DNA-binding subunit of NF-Y, produces two alternatively spliced transcripts, NF-YAs and NF-YAl. Bioinformatic analyses pointed at NF-YA splicing as a key transcriptional signature to discriminate between different tumor molecular subtypes. In this study, we aimed to determine the pathophysiological role of NF-YA splice variants in PCa and their association with aggressive subtypes

High-fidelity parallel entangling gates on a neutral atom quantum computer

The ability to perform entangling quantum operations with low error rates in a scalable fashion is a central element of useful quantum information processing. Neutral atom arrays have recently emerged as a promising quantum computing platform, featuring coherent control over hundreds of qubits and any-to-any gate connectivity in a flexible, dynamically reconfigurable architecture. The major outstanding challenge has been to reduce errors in entangling operations mediated through Rydberg interactions. Here we report the realization of two-qubit entangling gates with 99.5% fidelity on up to 60 atoms in parallel, surpassing the surface code threshold for error correction. Our method employs fast single-pulse gates based on optimal control, atomic dark states to reduce scattering, and improvements to Rydberg excitation and atom cooling. We benchmark fidelity using several methods based on repeated gate applications, characterize the physical error sources, and outline future improvements. Finally, we generalize our method to design entangling gates involving a higher number of qubits, which we demonstrate by realizing low-error three-qubit gates. By enabling high-fidelity operation in a scalable, highly connected system, these advances lay the groundwork for large-scale implementation of quantum algorithms, error-corrected circuits, and digital simulations.Comment: 5 pages, 4 figures. Methods: 13 pages, 10 figure