Numerical framework for transcritical real-fluid reacting flow simulations using the flamelet progress variable approach

An extension to the classical FPV model is developed for transcritical real-fluid combustion simulations in the context of finite volume, fully compressible, explicit solvers. A double-flux model is developed for transcritical flows to eliminate the spurious pressure oscillations. A hybrid scheme with entropy-stable flux correction is formulated to robustly represent large density ratios. The thermodynamics for ideal-gas values is modeled by a linearized specific heat ratio model. Parameters needed for the cubic EoS are pre-tabulated for the evaluation of departure functions and a quadratic expression is used to recover the attraction parameter. The novelty of the proposed approach lies in the ability to account for pressure and temperature variations from the baseline table. Cryogenic LOX/GH2 mixing and reacting cases are performed to demonstrate the capability of the proposed approach in multidimensional simulations. The proposed combustion model and numerical schemes are directly applicable for LES simulations of real applications under transcritical conditions.Comment: 55th AIAA Aerospace Sciences Meeting, Dallas, T

Amino Acids Were Not All Created Equal

The contention that amino acids were not all created equal is based on the simple premise that intestinal uptakes of non-bound (synthetic, crystalline, feed-grade) amino acids are more rapid than their protein-bound counterparts. The post-enteral ramifications of this difference in bioequivalence are amplified in broiler chickens given their express growth rates and just one complication is the post-prandial oxidation of amino acids. The lack of bioequivalence between non-bound and protein-bound amino acids is a real obstacle to the development and adoption of reduced-crude protein diets that have the potential to promote sustainable chicken-meat production Thus, the purpose of this paper is to examine our contention that amino acids were no longer created equal with the introduction of non-bound amino acids

Amino Acids Were Not All Created Equal

The contention that amino acids were not all created equal is based on the simple premise that intestinal uptakes of non-bound (synthetic, crystalline, feed-grade) amino acids are more rapid than their protein-bound counterparts. The post-enteral ramifications of this difference in bioequivalence are amplified in broiler chickens given their express growth rates and just one complication is the post-prandial oxidation of amino acids. The lack of bioequivalence between non-bound and protein-bound amino acids is a real obstacle to the development and adoption of reduced-crude protein diets that have the potential to promote sustainable chicken-meat production Thus, the purpose of this paper is to examine our contention that amino acids were no longer created equal with the introduction of non-bound amino acids

Modeling and Real-Time Simulation of a Vascularized Liver Tissue

International audienceIn Europe only, about 100,000 deaths per year are related to cirrhosis or liver cancer. While surgery remains the option that offers the foremost success rate against such pathologies, several limitations still hinder its widespread development. Among the limiting factors is the lack of accurate planning systems, which has been a motivation for several recent works, aiming at better resection planning and training systems, relying on pre-operative imaging, anatomical and biomechanical modelling. While the vascular network in the liver plays a key role in defining the operative strategy, its influence at a biomechanical level has not been taken into account. In the paper we propose a real-time model of vascularized organs such as the liver. The model takes into account separate constitutive laws for the parenchyma and vessels, and defines a coupling mechanism between these two entities. In the evaluation section, we present results of in vitro porcine liver experiments that indicate a significant influence of vascular structures on the mechanical behaviour of tissue. We confirm the val- ues obtained in the experiments by computer simulation using standard FEM. Finally, we show that the conventional modelling approach can be efficiently approximated with the proposed composite model capable of real-time calculations

An Evaluation of the Use of a Quantitative Image Analyzer to Determine Microhardness Values

The use of quantitative image analyzer to determine microhardness values was investigated. Microhardness traverses were made across chemically polished, partially oxidized T-111 alloy specimens using both Vickers and Knoop indenters. Microhardness values were obtained from both area and diagonal readings using a Classimat image analyzer (Classimat is a registered trademark of E. Leitz, Inc., Rockliegh, N. J.). These values were then compared with those obtained by conventional optical measurements. The data obtained by the various methods are compared and the advantages and disadvantages such as accuracy, time requirements, versatility, and limitations of particular methods are discussed

Taxa de corte sustentável para manejo das florestas tropicais.

Existe uma grande lacuna dos planos de manejo de florestas tropicais com relação à intensidade de extração e às taxas de corte, usualmente sendo definidas de forma arbitrária. Este trabalho visa definir intensidades de corte diferenciadas para grupos de espécies arbóreas comerciais, com diferentes ritmos de crescimento, por unidade de produção, no estado do Amazonas. Utilizou-se o incremento periódico anual percentual em volume, de 26 espécies arbóreas, obtido de parcelas permanentes. O incremento periódico anual, percentual em volume, para efeito diferenciador, considerou 1% como diferença limite. Foram identificadas três intensidades de corte, para as classes comerciais: 24,4% (grupo I), 35,4% (grupo II) e 42,4% (grupo III). Considerando a exploração total sustentável por hectare, para as 26 espécies, seria de 11,5 m³ha-1 com intensidade de corte de 37%. O procedimento de cálculo é simples e pode ser utilizado pelos órgãos fiscalizadores, certificadores ou legisladores como balizador do ciclo de corte e taxa de corte

Taxa de corte sustentável para manejo das florestas tropicais.

Existe uma grande lacuna dos planos de manejo de florestas tropicais com relação à intensidade de extração e às taxas de corte, usualmente sendo definidas de forma arbitrária. Este trabalho visa definir intensidades de corte diferenciadas para grupos de espécies arbóreas comerciais, com diferentes ritmos de crescimento, por unidade de produção, no estado do Amazonas. Utilizou-se o incremento periódico anual percentual em volume, de 26 espécies arbóreas, obtido de parcelas permanentes. O incremento periódico anual, percentual em volume, para efeito diferenciador, considerou 1% como diferença limite. Foram identificadas três intensidades de corte, para as classes comerciais: 24,4% (grupo I), 35,4% (grupo II) e 42,4% (grupo III). Considerando a exploração total sustentável por hectare, para as 26 espécies, seria de 11,5 m³ha-1 com intensidade de corte de 37%. O procedimento de cálculo é simples e pode ser utilizado pelos órgãos fiscalizadores, certificadores ou legisladores como balizador do ciclo de corte e taxa de corte

Using LES to Study Reacting Flows and Instabilities in Annular Combustion Chambers

Great prominence is put on the design of aeronautical gas turbines due to increasingly stringent regulations and the need to tackle rising fuel prices. This drive towards innovation has resulted sometimes in new concepts being prone to combustion instabilities. In the particular field of annular combustion chambers, these instabilities often take the form of azimuthal modes. To predict these modes, one must compute the full combustion chamber, which remained out of reach until very recently and the development of massively parallel computers. Since one of the most limiting factors in performing Large Eddy Simulation (LES) of real combustors is estimating the adequate grid, the effects of mesh resolution are investigated by computing full annular LES of a realistic helicopter combustion chamber on three grids, respectively made of 38, 93 and 336 million elements. Results are compared in terms of mean and fluctuating fields. LES captures self-established azimuthal modes. The presence and structure of the modes is discussed. This study therefore highlights the potential of LES for studying combustion instabilities in annular gas turbine combustors

A Phase I Trial of Aminolevulinic Acid-Photodynamic Therapy for Treatment of Oral Leukoplakia

Background Photodynamic therapy with aminolevulinic acid (ALA PDT) for oral leukoplakia has shown promising effects in regression of oral leukoplakia. Although ALA has been extensively studied and is an ideal photosensitizer, the optimal light dose for treatment of oral leukoplakia has not been determined. We conducted a phase I study to determine MTD and DLT of PDT in patients treated with ALA for leukoplakia. Methods Patients with histologically confirmed oral leukoplakia received a single treatment of ALA PDT in cohorts with escalating doses of light (585 nm). Clinical, histologic, and biologic markers were assessed. Results Analysis of 11 participants is reported. No significant toxicity from ALA PDT was observed in patients who received ALA with a light dose of up to 4 J/cm2. One participant experienced transient grade 3 transaminase elevation due to ALA. One participant had a partial clinical response 3 months after treatment. Biologic mucosal risk markers showed no significant associations. Determination of MTD could not be accomplished within a feasible timeframe for completion of the study. Conclusions ALA PDT could be safely administered with a light dose up to 4 J/cm2 and demonstrated activity. Larger studies are needed to fully elucidate the MTD and efficacy of ALA-PDT