On the Design and Development of WEBSEE: A Web-based Senior Exit Exam for Value-added Assessment of a CIS Program

Higher education institutions are becoming increasingly engaged in assessing their programs in order to enhance student learning outcomes. States, accreditation bodies and various organizations are calling upon institutions to buildup their accountability towards student learning. Accordingly, multiple assessment methods (both direct and indirect) are being used to gather program assessment data. The paper outlines the framework that has been undertaken to design and implement a Webbased Senior Exit Exam (WEBSEE). This exam is being used as a major direct assessment instrument for an undergraduate program in Computing Information Systems (CIS). The assessment framework is deemed important to enhance the validity of the exam, making it more appropriate for measuring what it tries to measure. The paper also shares some guidelines that have been used to generate reliable and valid exam questions which are directly mapped to program outcomes. The exam questions have been designed to span across a range of IS knowledge areas, knowledge depths and difficulty levels. Our research also outlines the importance to integrate the exit exam in the credit-bearing curriculum to drive students\u27 learning through motivation. The assessment data collected has uncovered some deficiencies that when addressed will help improve student learning. The collected data will also be used as a reference baseline to historically track achievement of program outcomes over the next semesters. The approach and research methodology presented in this study can be useful for IS departments planning to administer similar kind of locally-developed exit exams in future

A framework towards assessing the merits of inviting IT professionals to the classroom

For the past years, the academic IT profession through various professional society curriculum committees and accreditation bodies has made considerable progress to revise and update IT curricula to meet the changing needs of the profession. In particular, learning techniques, beyond classroom teaching activities, have been recognized as essential ingredients to enhance the learning outcomes of advanced-level IT courses. This study outlines an assessment framework to explore the merits of inviting IT professionals as a pedagogical technique to integrate real world IT experience into the classroom. Though the general merits of inviting guest speakers have been confirmed in many previous (non-IT related) studies, these events are particularly much needed in the IT field. This urgency is justified by many factors such as the complex and constantly changing IT profession and its environment, the rapid pace in the rollout/phase-out of IT technologies and terminologies, and the shallow focus on professional orientation in most IT curricula. Our study confirms some of the merits of inviting guest speakers as reported in the literature. It also adds to existing literature in at least three aspects. First, to our best knowledge, this is the first reported study that reflects upon the usage of guest speakers in IT classrooms. Second, our research is a first initiative that contributes to establishing a formal framework for the planning an

Relationships between Virulence Genes and Antibiotic Resistance Phenotypes/Genotypes in Campylobacter spp. Isolated from Layer Hens and Eggs in the North of Tunisia: Statistical and Computational Insights

Globally, Campylobacter is a significant contributor to gastroenteritis. Efficient pathogens are qualified by their virulence power, resistance to antibiotics and epidemic spread. However, the correlation between antimicrobial resistance (AR) and the pathogenicity power of pathogens is complex and poorly understood. In this study, we aimed to investigate genes encoding virulence and AR mechanisms in 177 Campylobacter isolates collected from layer hens and eggs in Tunisia and to assess associations between AR and virulence characteristics. Virulotyping was determined by searching 13 virulence genes and AR-encoding genes were investigated by PCR and MAMA-PCR. The following genes were detected in C. jejuni and C. coli isolates: tet(O) (100%/100%), blaOXA-61 (18.82%/6.25%), and cmeB (100%/100%). All quinolone-resistant isolates harbored the Thr-86-Ile substitution in GyrA. Both the A2074C and A2075G mutations in 23S rRNA were found in all erythromycin-resistant isolates; however, the erm(B) gene was detected in 48.38% and 64.15% of the C. jejuni and C. coli isolates, respectively. The machine learning algorithm Random Forest was used to determine the association of virulence genes with AR phenotypes. This analysis showed that C. jejuni virulotypes with gene clusters encompassing the racR, ceuE, virB11, and pldA genes were strongly associated with the majority of phenotypic resistance. Our findings showed high rates of AR and virulence genes among poultry Campylobacter, which is a cause of concern to human health. In addition, the correlations of specific virulence genes with AR phenotypes were established by statistical analysis

The First Snake Venom KTS/Disintegrins-Integrin Interactions Using Bioinformatics Approaches

Snake venom contains a number of active molecules that have been shown to possess high anti-tumor activities; disintegrins are an excellent example among these. Their ability to interact and bind with integrins suggests that they could be very valuable molecules for the development of new cancer therapeutic approaches. However, in the absence of a clear Lysine-Threonine-Serine (KTS) Disintegrins Integrin interaction model, the exact compound features behind it are still unknown. In this study, we investigated the structural characteristics of three KTS-disintegrins and the interaction mechanisms with the α1β1 integrin receptor using in silico bioinformatics approaches. Normal mode analysis showed that the flexibility of the KTSR motif and the C-terminal region play a key role and influence the KTS-Disintegrin-integrin interaction. Protein-protein docking also suggested that the interaction involving the KTSR motif is highly dependent on the residue following K21, S23 and R24. These findings contribute to a better understanding of the KTS-Disintegrin-Integrin structural differences and their interactions with α1β1 receptors, which could improve the selection process of the best active molecules for antitumor therapies