2 research outputs found
Design of Xylose-Based Semisynthetic Polyurethane Tissue Adhesives with Enhanced Bioactivity Properties
Developing biocompatible tissue adhesives
with high adhesion properties is a highly desired goal of the tissue
engineering due to adverse effects of the sutures. Therefore, our
work involves synthesis, characterization, adhesion properties, protein
adsorption, <i>in vitro</i> biodegradation, <i>in vitro</i> and <i>in vivo</i> biocompatibility properties of xylose-based
semisynthetic polyurethane (NPU-PEG-X) bioadhesives. Xylose-based
semisynthetic polyurethanes were developed by the reaction among 4,4′-methylenebis(cyclohexyl
isocyanate) (MCI), xylose and polyethylene glycol 200 (PEG). Synthesized
polyurethanes (PUs) showed good thermal stability and high adhesion
strength. The highest values in adhesion strength were measured as
415.0 ± 48.8 and 94.0 ± 2.8 kPa for aluminum substrate and
muscle tissue in 15% xylose containing PUs (NPU-PEG-X-15%), respectively.
The biodegradation of NPU-PEG-X-15% was also determined as 19.96 ±
1.04% after 8 weeks of incubation. Relative cell viability of xylose
containing PU was above 86%. Moreover, 10% xylose containing NPU-PEG-X
(NPU-PEG-X-10%) sample has favorable tissue response, and inflammatory
reaction between 1 and 6 weeks implantation period. With high adhesiveness
and biocompatibility properties, NPU-PEG-X can be used in the medical
field as supporting materials for preventing the fluid leakage after
abdominal surgery or wound closure