Categories of psychometric tests.

<p>Categories of psychometric tests.</p

Flow diagram of study selection.

<p>Flow diagram of study selection.</p

Calculation of proportional impairment ratio for subjective tests for the second-generation antihistamines in Japan.

<p>a: Number of tests showing ‘impairment’ with the named antihistamine (AH). b: Number of tests showing ‘no impairment’ with the named AH. c: Number of tests showing ‘impairment’ with all other AHs. d: Number of tests showing ‘no impairment’ with all other AHs. L: Lower limit. U: Upper limit. The vertical dotted line in the figure of PIRs shows a value of 1.</p

Calculation of proportional impairment ratio for objective tests for the second-generation antihistamines in Japan.

<p>a: Number of tests showing ‘impairment’ with the named antihistamine (AH). b: Number of tests showing ‘no impairment’ with the named AH. c: Number of tests showing ‘impairment’ with all other AHs. d: Number of tests showing ‘no impairment’ with all other AHs. L: Lower limit. U: Upper limit. The vertical dotted line in the figure of PIRs shows a value of 1.</p

Calculation of proportional impairment ratio for objective tests by dose.

<p>a: Number of tests showing ‘impairment’ with the named antihistamine (AH). b: Number of tests showing ‘no impairment’ with the named AH. c: Number of tests showing ‘impairment’ with all other AHs. d: Number of tests showing ‘no impairment’ with all other AHs. L: Lower limit. U: Upper limit. The vertical dotted line in the figure of PIRs shows a value of 1.</p

Number of test results showing impairment and no impairment for each AH by dose.

<p>Number of test results showing impairment and no impairment for each AH by dose.</p

Proportional impairment ratio calculation formula for an antihistamine.

<p>a: Number of tests showing ‘impairment’ with the named antihistamine (AH). b: Number of tests showing ‘no impairment’ with the named AH. c: Number of tests showing ‘impairment’ with all other AHs. d: Number of tests showing ‘no impairment’ with all other AHs.</p