Primary diseases requiring endoscopic examination.

Primary diseases requiring endoscopic examination.</p

Inactivating activity of EAW against SARS-CoV-2.

Inactivating activity of EAW against SARS-CoV-2.</p

Characteristics of patients and endoscopes included in this study.

Characteristics of patients and endoscopes included in this study.</p

Reduction of bacteria by EAW.

Reduction of bacteria by EAW.</p

Peak picking and statistical analysis of mass spectra in case 1.

<p>Peak picking and statistical analysis of mass spectra in case 1.</p

HE-stained section of case 1.

<p>(A) Thyroid papillary cancer tissue was localized on the left, and normal thyroid tissue was localized on the right (original magnification 40×). The stromal region was excluded. The ROI was determined from the corresponding HE-staining results. The black boxes indicate the representative region of cancer and normal thyroid tissue. (B) Magnified representative regions of cancer and normal tissue (original magnification 200×). The cancer cells had a high cytoplasmic ratio and displayed nuclear features characteristic of papillary thyroid cancer. Histologic findings of thyroid papillary cancer consisted of columnar thyroidal epithelium set in papillary projection. The normal thyroid tissue is composed of many spherical hollow sacs called thyroid follicles.</p

Overview of the <i>m/z</i> values that had higher expression levels in cancer regions of all cases.

<p>Overview of the <i>m/z</i> values that had higher expression levels in cancer regions of all cases.</p

Averaged spectrum for case 1.

<p>(A) Spectrum of the cancer region and (B) spectrum of normal region. Each spectrum was averaged from the ROI of cancer and normal tissue in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048873#pone-0048873-g001" target="_blank">Figure 1</a>. Each number shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048873#pone-0048873-t001" target="_blank">Table 1</a> was assigned using these spectra.</p

Visualization of molecular distribution in case 1.

<p>We visualized ion images corresponding to the results shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048873#pone-0048873-t001" target="_blank">Table 1</a>. In all images, the cancer tissue is on the left and normal tissue is on the right. The distribution of the intensity for each <i>m/z</i> value was not constant in the cancer and normal thyroid tissue.</p

Visualization of molecular distribution of <i>m/z</i> values that were expressed to higher levels in cancer tissue from all cases.

<p>The ROI of each case is defined by a dashed line in HE-staining images. The intensity of all values in the cancer region was higher than in normal regions. The distribution of intensity in <i>m/z</i> 741.5 was different from the distribution of intensity in the other <i>m/z</i> values.</p