Evaluation of water flushing effect on icebreaking operation of “Shirase” by analysis of Japanese Antarctic Research Expedition voyage data

The Tenth Symposium on Polar Science/Ordinary sessions: [OM] Polar Meteorology and Glaciology, Thu. 5 Dec. / 2F Auditorium , National Institute of Polar Researc

Prospective Study of the Effect of the 21-Gene Assay on Adjuvant Clinical Decision-Making in Japanese Women With Estrogen Receptor-Positive, Node-Negative, and Node-Positive Breast Cancer

AbstractBackgroundIn this study we investigated if the 21-gene assay result affects adjuvant decision-making in Japanese women with ER+ invasive EBC.Patients and MethodsA total of 124 consecutive eligible patients with ER+, HER2-negative EBC and 0 to 3 positive lymph nodes were enrolled. Treatment recommendations, physicians' confidence and patients' decisional conflict before and after knowledge of the Recurrence Score results of the 21-gene assay were recorded.ResultsOne-hundred four patients (84%) had N0 disease, including micrometastases, and 20 (16%) had N+ disease. Overall, recommendations changed in 33% (95% CI, 24%-43%) of N0 and 65% (95% CI, 41%-85%) of N+ patients. In 27 of 48 (56%) of N0 and 13 of 15 (87%) of N+ patients an initial recommendation for chemohormonal therapy was revised to only hormonal therapy after assay results, and in 7 of 56 (13%) of N0 and 0 of 5 N+ patients from only hormonal to combined chemohormonal therapy. Decisions appeared to follow the Recurrence Score results for low and high values. For patients with intermediate Recurrence Score values, overall recommendations for chemohormonal treatment tended to decrease after assay results. Physicians' confidence increased in 106 of 124 (85.5%; 95% CI, 78%-91%) cases. Patients' decisional conflict significantly improved as indicated by changes in the total score and the 5 defined subscores (P = .014 for Informed Subscore; P < .001 for all others).ConclusionResults from this prospective study in a Japanese population confirm an effect of the 21-gene assay results on adjuvant treatment decision-making, consistent with reported experiences from the United States and Europe

ON THE IMPORTANCE OF FRANCK- CONDON FACTORS IN SECOND-ORDER SPIN-ORBIT COUPLING: ISOTOPE EFFECT ON THE FINE-STRUCTURE PARAMETERS OF 3(nπ∗)^{3}(n\pi^{*}) BENZOPHENONES

$^{1}$R. M. Hochstrasser, G. W. Scott and A. H. Zewail, Mol. Phys. 36, 475 (1978).Author Institution:Isotope effects on the fine-structure parameters of $^{3}(n\pi^{*})$ benzophenones containing $^{1}H,\ ^{2}H,\ ^{12}C,\ ^{13}C,\ ^{16}O$, and $^{18}O$ nuclei have been examined by zero-field optically-detected magnetic resonance (zf-ODMR) spectroscopy. A portion of these results have recently been reported by Hochstrasser, Scott and $Zewail.^{1}$ The changes produced by $^{2} H$ and $^{13}C$ substitution are different in magnitude and opposite in sign, those produced by $^{13}C$ and $^{18}O$ substitution are similar in magnitude as well as sign, and those produced by simultaneous $^{2}H$ and $^{13}C$ substitution are additive. Concomitant changes are observed in the phosphorescence spectra of these species. A comparison of the data provides direct experimental evidence for the importance of Franck-Condon factors in determining the extent to which the lowest triplet state is mixed with nearby states via the spin-orbit interaction