Oneness in One Health

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The Peacekeeping System of the United Nations and its Potential Role in One Health. Looking at its Principles, Policies, and Key Technical Entities

Our twenty-first century is a time of heightened risks and benefits for humans, animals, plants, and environmental health. The prospects for successfully addressing such considerations are pursuing a One Health approach. This is the right moment to consider opportunities to apply some or all aspects of the One Health approach

Surface modification to improve in vitro attachment and proliferation of human urinary tract cells

To evaluate the attachment and proliferation of cultured human urinary tract cells to culture plates surface-modified by photochemical immobilization of extracellular matrix (ECM) proteins. MATERIALS AND METHODS Human uroepithelial (UEC) and smooth muscle (SMC) cells were harvested from ureter and expanded in culture; 24-well culture plates surface-modified by photochemical covalent immobilization of ECM proteins were then seeded with UEC or SMC. To characterize cellular attachment, cells were incubated on surface-modified plates for 30 and 90 min. For proliferation assays the cells were incubated for 3 12 days. Standard tissue culture plates with no surface modification and sham-modified plates served as controls. Differential attachment and proliferation on the various surfaces were assessed using analysis of variance with Fisher's posthoc test for multiple comparisons. RESULTS Attachment at 30 and 90 min of both UEC and SMC on plates surface-modified with ECM proteins was significantly greater than in control plates. Surface-modification with collagen resulted in significantly greater cellular attachment than with either laminin or fibronectin. UEC proliferation was also significantly greater than in control plates by surface-modification with collagen and fibronectin, but not with laminin. SMC proliferation was significantly better after surface modification than on sham- modified plates, but was no better than standard plates. CONCLUSIONS Covalent photochemical immobilization of ECM proteins to potential growth surfaces enhances the attachment of cultured UEC and SMC and the proliferation of UEC. This technique might be useful in modifying surface properties of synthetic polymer-based materials in a controlled and defined manner, giving them the capacity to promote and sustain the growth of urinary tract cells. This may lead to development of alternative methods of tissue engineering in the urinary tract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73750/1/j.1464-410X.2003.04418.x.pd

A Canine Model to Assess the Biochemical Stress Response to Laparoscopic and Open Surgery

Purpose: To develop an animal model to assess the stress response to open and laparoscopic surgery. Such a model would allow objective physiologic assessment of the putative benefits of laparoscopy and provide a framework in which to compare modifications in operative and anesthetic technique that might decrease the stress of surgery. Materials and Methods: Mongrel dogs underwent laparoscopic (N = 12) or open surgical (N = 12) left nephrectomy. In 11 control animals, after induction of anesthesia and line placement, the animal underwent either no intervention (open surgery sham; N = 6) or pneumoperitoneum only (laparoscopic sham; N = 5). Serum glucose and cortisol were measured preoperatively, at skin closure, and at 4, 8, and 24 hours postoperatively. Values at each time point were compared in the laparoscopic and open surgical nephrectomy groups and in each of the two nephrectomy groups and their respective shams. Results: Compared with baseline, there was a sharp rise in serum cortisol at the time of skin closure, with a gradual decline to baseline values by 24 hours, in all experimental animals. Significantly lower serum cortisol concentrations were seen at 4 and 8 hours postoperatively in the laparoscopic group than in the open surgery group. Cortisol was significantly higher in the open group than in the sham-open group at all time points, whereas cortisol was greater in the laparoscopic group than in the pneumoperitoneum-only group only at the 4-hour time point. No differences were seen in serum glucose between groups. Conclusions: The serum cortisol concentration appears to be a good measure of surgical stress in the canine model. The rapid decline in serum cortisol after laparoscopy compared with open surgery may indicate a lesser degree, or quicker resolution, of surgical stress in the former. Furthermore, the similarity in cortisol curves between laparoscopy and pneumoperitoneum only suggests that surgical stress in laparoscopic surgery may be attributable mainly to the effects of pneumoperitoneum.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63212/1/089277901317203100.pd

EXCHANGE AND COORDINATION: CHALLENGES OF THE GLOBAL ONE HEALTH MOVEMENT

Current economic, social, and environmental trajectories within most world regions are unsustainable. Interaction between bottom-up initiatives and top-down good governance is essential to change them. The One Health movement, made up of many organizations, groups, and individuals from diverse backgrounds and disciplines, seeks to redress the present trajectories but has lacked coordination and cooperation, limiting its effectiveness to date. We take a snapshot of groups/organizations working to promote One Health, explore options to increase cooperation and coordination among global One Health stakeholders, and propose systemic strategies that could positively impact animals, people, the planet, plants, and politics.                                                Methods: Through a review of the compilation of Who’s Who in One Health organizations on the One Health Commission’s (OHC) website and the list of organizations that have pledged support for One Health listed on the One Health Initiative (OHI) website, 289 organizations were identified (as of 29 July 2022: 126 Civil Society Organizations, 133 academic and 30 governmental organizations). A stratified sampling approach and MAXQDA 2022 were used in a mixed-methods analysis to select a sample (N=50) of organizations to evaluate with 10 questions on purpose & focus, structure & transparency, cooperation & implementation, and publications. Results: The words “One Health” appeared in the organizations’ names on 62.0% (N=31) of websites examined, most often those in academic settings (78.2%). As regards transparency of the organizational structures, membership was defined in 70.0% (N=35),  again most often by academic organizations (82.6%). Members of the governing structures were named on 34.0% of organizational websites.  Projects led in the last two years were described on 32.0%, and cooperation with other organizations was indicated on 64.0% of websites examined.  Relevant publications and annual reports were listed on 46.0% and 24.0% of probed websites, respectively. Ranking the number of positive findings for each of the 50 organizations examined revealed that full information for all ten questions was provided by only 4 academic and 1 governmental organization. The OHC website was used as a starting point and thus was not included in the N=50 samples. It was therefore examined as an example of a Non-Profit / CSO working to support bottom-up One Health leadership. Since 2014 the OHC has supported a Global One Health Community listserv of individuals from around the globe. The analysis revealed a dominance of Directors from the US and a high proportion of organizations included on the OHC Who’s Who in One Health organizations webpage were located in North America. The social sciences - sociology and economics in particular – were underrepresented among in its . Conclusion: These 10 questions may not have been fully appropriate for all organizations examined in academic or government settings versus stand-alone non-profit or civil society organizations. However, an examination of the 50 selected websites of organizations working to implement One Health and/or framing their projects and purpose in One Health revealed the global One Health movement to be fragmented and uncoordinated. The authors propose to form a more unified voice for One Health across the international One Health movement, a fully networked, informal global One Health alliance or community of practice that can coordinate sharing of information among the networks and with the general public,  and that is able to seek synergies and joining of hands in collective/collaborative actions to effectively and efficiently promote and support bottom-up efforts

EXCHANGE AND COORDINATION: CHALLENGES OF THE GLOBAL ONE HEALTH MOVEMENT

Current economic, social, and environmental trajectories within most world regions are unsustainable. Interaction between bottom-up initiatives and top-down good governance is essential to change them. The One Health movement, made up of many organizations, groups, and individuals from diverse backgrounds and disciplines, seeks to redress the present trajectories but has lacked coordination and cooperation, limiting its effectiveness to date. We take a snapshot of groups/organizations working to promote One Health, explore options to increase cooperation and coordination among global One Health stakeholders, and propose systemic strategies that could positively impact animals, people, the planet, plants, and politics.Methods: Through a review of the compilation of Who’s Who in One Health organizations on the One Health Commission’s (OHC) website and the list of organizations that have pledged support for One Health listed on the One Health Initiative (OHI) website, 289 organizations were identified (as of 29 July 2022: 126 Civil Society Organizations, 133 academic and 30 governmental organizations). A stratified sampling approach and MAXQDA 2022 were used in a mixed-methods analysis to select a sample (N=50) of organizations to evaluate with 10 questions on purpose & focus, structure & transparency, cooperation & implementation, and publications. Results: The words “One Health” appeared in the organizations’ names on 62.0% (N=31) of websites examined, most often those in academic settings (78.2%). As regards transparency of the organizational structures, membership was defined in 70.0% (N=35), again most often by academic organizations (82.6%). Members of the governing structures were named on 34.0% of organizational websites. Projects led in the last two years were described on 32.0%, and cooperation with other organizations was indicated on 64.0% of websites examined. Relevant publications and annual reports were listed on 46.0% and 24.0% of probed websites, respectively. Ranking the number of positive findings for each of the 50 organizations examined revealed that full information for all ten questions was provided by only 4 academic and 1 governmental organization.The OHC website was used as a starting point and thus was not included in the N=50 samples. It was therefore examined as an example of a Non-Profit / CSO working to support bottom-up One Health leadership. Since 2014 the OHC has supported a Global One Health Community listserv of individuals from around the globe. The analysis revealed a dominance of Directors from the US and a high proportion of organizations included on the OHC Who’s Who in One Health organizations webpage were located in North America. The social sciences - sociology and economics in particular – were underrepresented among in its leadership. Conclusion: These 10 questions may not have been fully appropriate for all organizations examined in academic or government settings versus stand-alone non-profit or civil society organizations. However, an examination of the 50 selected websites of organizations working to implement One Health and/or framing their projects and purpose in One Health revealed the global One Health movement to be fragmented and uncoordinated. The authors propose to form a more unified voice for One Health across the international One Health movement, a fully networked, informal global One Health alliance or community of practice that can coordinate sharing of information among the networks and with the general public, and that is able to seek synergies and joining of hands in collective/collaborative actions to effectively and efficiently promote and support bottom-up efforts

Editorial : one health, environmental health, global health, and inclusive governance: what can we do?

No abstract available.https://www.frontiersin.org/journals/public-healthdm2022School of Health Systems and Public Health (SHSPH