Massless D-Branes on Calabi-Yau Threefolds and Monodromy

We analyze the link between the occurrence of massless B-type D-branes for specific values of moduli and monodromy around such points in the moduli space. This allows us to propose a classification of all massless B-type D-branes at any point in the moduli space of Calabi-Yau's. This classification then justifies a previous conjecture due to Horja for the general form of monodromy. Our analysis is based on using monodromies around points in moduli space where a single D-brane becomes massless to generate monodromies around points where an infinite number become massless. We discuss the various possibilities within the classification.Comment: 29 pages, LaTeX2e, 3 figures, author order fixe

Exact Lagrangian submanifolds in simply-connected cotangent bundles

We consider exact Lagrangian submanifolds in cotangent bundles. Under certain additional restrictions (triviality of the fundamental group of the cotangent bundle, and of the Maslov class and second Stiefel-Whitney class of the Lagrangian submanifold) we prove such submanifolds are Floer-cohomologically indistinguishable from the zero-section. This implies strong restrictions on their topology. An essentially equivalent result was recently proved independently by Nadler, using a different approach.Comment: 28 pages, 3 figures. Version 2 -- derivation and discussion of the spectral sequence considerably expanded. Other minor change

Impacts of Organic and Conventional Management on the Nutritional Level of Vegetables

The nutrient concentration of fruits and vegetables in the U.S.A. has declined in the past 50–70 years. Crop management practices utilizing on-farm inputs are thought to increase crop nutritional quality, but few studies have evaluated this under long-term side-by-side trials. An experiment was conducted from 2004 to 2005 at Rodale Institute’s long-term Farming Systems Trial to investigate the nutritional quality of vegetables under organic manure (MNR) and conventional (CNV) farming systems, with or without arbuscular mycorrhizal fungi (AMF) treatment. AMF reduced the vitamin C content in carrots in both systems in 2004, but the reduction was 87% in CNV and 28% in MNR. AMF also reduced antioxidants in carrots in both CNV and MNR. This trend was likely due to the suppression of native AMF colonization by the non-native AMF inoculum used. Between 2004 and 2005, MNR increased the vitamin C in green peppers by 50% while CNV decreased the vitamin C in red peppers by 48%. Tomatoes under MNR had a 40% greater vitamin C content compared to CNV in 2005. The vegetable yield declined between 2004 and 2005, except for tomato, where the yield increased by 51% and 44% under CNV and MNR, respectively. In general, MNR tended to increase the nutrient concentration of vegetables compared with CNV, while the AMF effects were inconclusive

Event Horizons in Numerical Relativity I: Methods and Tests

This is the first paper in a series on event horizons in numerical relativity. In this paper we present methods for obtaining the location of an event horizon in a numerically generated spacetime. The location of an event horizon is determined based on two key ideas: (1) integrating backward in time, and (2) integrating the whole horizon surface. The accuracy and efficiency of the methods are examined with various sample spacetimes, including both analytic (Schwarzschild and Kerr) and numerically generated black holes. The numerically evolved spacetimes contain highly distorted black holes, rotating black holes, and colliding black holes. In all cases studied, our methods can find event horizons to within a very small fraction of a grid zone.Comment: 22 pages, LaTeX with RevTeX 3.0 macros, 20 uuencoded gz-compressed postscript figures. Also available at http://jean-luc.ncsa.uiuc.edu/Papers/ Submitted to Physical Review

Mammalian expression of the human sex steroid-binding protein of plasma (SBP or SHBG) and testis (ABP) Characterization of the recombinant protein

AbstractA full-length 1,209 bp cDNA encoding the human sex steroid-binding protein of plasma (SBP or SHBG) and testis (ABP) was constructed and expressed in BHK-21 cells. The sequence agrees with the published gene and protein sequences. The cells were found to secrete SBP following transfection and G418r selection. The recombinant protein binds 5α-dihydrotestosterone with a Kd of 0.28 nM. It also binds testosterone and 17β-estradiol but not progesterone, estrone or cortisol revealing a steroid-binding specificity identical to that of human SBP, SDS-PAGE patterns are less complex than human SBP and show a monomeric molecular weight of about 43 kDa

Event Horizons in Numerical Relativity II: Analyzing the Horizon

We present techniques and methods for analyzing the dynamics of event horizons in numerically constructed spacetimes. There are three classes of analytical tools we have investigated. The first class consists of proper geometrical measures of the horizon which allow us comparison with perturbation theory and powerful global theorems. The second class involves the location and study of horizon generators. The third class includes the induced horizon 2-metric in the generator comoving coordinates and a set of membrane-paradigm like quantities. Applications to several distorted, rotating, and colliding black hole spacetimes are provided as examples of these techniques.Comment: 23 double column pages including 28 figures. Higher quality figures (big size!) available upon request (jmasso OR [email protected]

A Point's Point of View of Stringy Geometry

The notion of a "point" is essential to describe the topology of spacetime. Despite this, a point probably does not play a particularly distinguished role in any intrinsic formulation of string theory. We discuss one way to try to determine the notion of a point from a worldsheet point of view. The derived category description of D-branes is the key tool. The case of a flop is analyzed and Pi-stability in this context is tied in to some ideas of Bridgeland. Monodromy associated to the flop is also computed via Pi-stability and shown to be consistent with previous conjectures.Comment: 15 pages, 3 figures, ref adde

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of glyoxalase 1 is linked to tumour multidrug resistance in cancer chemotherapy. We report herein that glycation of DNA by glyoxal and methylglyoxal produces a quantitatively important class of nucleotide adduct in physiological systems—imidazopurinones. The adduct derived from methylglyoxal-3-(2′-deoxyribosyl)-6,7-dihydro-6,7-dihydroxy-6/7-methylimidazo-[2,3-b]purine-9(8)one isomers—was the major quantitative adduct detected in mononuclear leukocytes in vivo and tumour cell lines in vitro. It was linked to frequency of DNA strand breaks and increased markedly during apoptosis induced by a cell permeable glyoxalase 1 inhibitor. Unexpectedly, the DNA content of methylglyoxal-derived imidazopurinone and oxidative marker 7,8-dihydro-8-oxo-2′-deoxyguanosine were increased moderately in glyoxalase 1-linked multidrug resistant tumour cell lines. Together these findings suggest that imidazopurinones are a major type of endogenous DNA damage and glyoxalase 1 overexpression in tumour cells strives to counter increased imidazopurinone formation in tumour cells likely linked to their high glycolytic activity

Solitons in Seiberg-Witten Theory and D-branes in the Derived Category

We analyze the "geometric engineering" limit of a type II string on a suitable Calabi-Yau threefold to obtain an N=2 pure SU(2) gauge theory. The derived category picture together with Pi-stability of B-branes beautifully reproduces the known spectrum of BPS solitons in this case in a very explicit way. Much of the analysis is particularly easy since it can be reduced to questions about the derived category of CP1.Comment: 20 pages, LaTex2