Impact of Micro Economic Variables on Firms Performance

The aim of our study is to analyze the factors that affect performance of the cement sector focusing particularly on Pakistani firms. The study further finds the impact of size on performance, to examine the relationship between age of the firm and firm performance, to measure the effect of growth on firm’s performance and to highlight the impact of leverage on performance of the firm. There are twenty six cement companies listed in KSE. However, for the purpose of this paper only twenty companies were selected whose data was readily available over the period of eleven years from 2002 to 2012. Methodology: The data for the study was extracted from the annual reports of all the companies. In this study panel data analysis is used. Findings: After analyzing the data we have come to a point that all of the four variables have significant impact on the performance of the firm. We have seen that leverage has a positive impact effect on the performance of the firm when ROA is analyzed. Size, age and growth have a positive impact on return on equity (ROE) while leverage has a negative impact. Recommendations: This paper shows new insights for policy makers to improve the performance of Pakistani firms

Impact of Micro Economic Variables on Firms Performance

The aim of our study is to analyze the factors that affect performance of the cement sector focusing particularly on Pakistani firms. The study further finds the impact of size on performance, to examine the relationship between age of the firm and firm performance, to measure the effect of growth on firm’s performance and to highlight the impact of leverage on performance of the firm. There are twenty six cement companies listed in KSE. However, for the purpose of this paper only twenty companies were selected whose data was readily available over the period of eleven years from 2002 to 2012. Methodology: The data for the study was extracted from the annual reports of all the companies. In this study panel data analysis is used. Findings: After analyzing the data we have come to a point that all of the four variables have significant impact on the performance of the firm. We have seen that leverage has a positive impact effect on the performance of the firm when ROA is analyzed. Size, age and growth have a positive impact on return on equity (ROE) while leverage has a negative impact. Recommendations: This paper shows new insights for policy makers to improve the performance of Pakistani firms

Hepatoprotective Effect of Extra Virgin Olive Oil and Apple Cider Vinegar in Type-2 Diabetic Rat Model

Introduction: Type-2 diabetes mellitus, a major public health problem, is caused by insulin resistance. In diabetics, chronic hyperglycemia results in formation of reactive oxygen species. Oxidative stress in diabetic patients is responsible for hepatic damage because it causes activation of several pro-inflammatory mediators in liver. Hepatic complications of diabetes include fatty liver disease, necrosis, cirrhosis, carcinoma and liver failure. Aims & Objectives: To determine and compare the hepatoprotective effect of extra virgin olive oil and apple cider vinegar in streptozotocin induced Type-2 diabetic rat model. Place and Duration of Study: This experimental study was conducted at Animal House of Postgraduate Medical Institute, Lahore, Pakistan from May 2021 to June 2021. Material & Methods: In this study, 40 male Sprague Dawley rats were divided into 4 groups i.e., Group I was NC (negative control), Group II PC (positive control), Group III EVOO (Extra virgin olive oil) and Group IV (Apple cider vinegar), each group having 10 rats. Diabetes was induced in all rats except the rats of NC group at the start of the study by intraperitoneal administration of injection nicotinamide, followed by injection STZ after 15 minutes. Group III was given 1ml/100gBW/ day EVOO and Group IV was given 2ml/kgBW/day diluted ACV with distilled water in 1:5 orally for 4 weeks. Terminal sampling was performed at the end of the 4th week for estimation of liver enzymes (ALT, ALP and AST) in serum. Data were entered and analyzed in SPSS version 26. p value of ? 0.05 was considered significant. Results: On comparison with PC group, both the treatment groups showed significant decrease in serum ALT levels with p values 0.026 for EVOO and < 0.001 for ACV. Serum ALP levels were also decreased significantly in both the treated groups with p value < 0.001 for EVOO as well as for the ACV group. However, reduction in serum AST levels was nonsignificant with p values 0.082 and 0.058 in EVOO and ACV groups respectively. Conclusion: Both EVOO and ACV have hepatoprotective effect in Type-2 diabetic rats. However, ACV is more effective

Diversity, Mutation and Recombination Analysis of Cotton Leaf Curl Geminiviruses.

The spread of cotton leaf curl disease in China, India and Pakistan is a recent phenomenon. Analysis of available sequence data determined that there is a substantial diversity of cotton-infecting geminiviruses in Pakistan. Phylogenetic analyses indicated that recombination between two major groups of viruses, cotton leaf curl Multan virus (CLCuMuV) and cotton leaf curl Kokhran virus (CLCuKoV), led to the emergence of several new viruses. Recombination detection programs and phylogenetic analyses showed that CLCuMuV and CLCuKoV are highly recombinant viruses. Indeed, CLCuKoV appeared to be a major donor virus for the coat protein (CP) gene, while CLCuMuV donated the Rep gene in the majority of recombination events. Using recombination free nucleotide datasets the substitution rates for CP and Rep genes were determined. We inferred similar nucleotide substitution rates for the CLCuMuV-Rep gene (4.96X10-4) and CLCuKoV-CP gene (2.706X10-4), whereas relatively higher substitution rates were observed for CLCuMuV-CP and CLCuKoV-Rep genes. The combination of sequences with equal and relatively low substitution rates, seemed to result in the emergence of viral isolates that caused epidemics in Pakistan and India. Our findings also suggest that CLCuMuV is spreading at an alarming rate, which can potentially be a threat to cotton production in the Indian subcontinent

Microemulsion-based synthesis of strontium hexaferrite cobalt iron oxide nanoparticles and their biocompatibility in albino mice

A number of strontium-based iron oxides are available for the industrial use. Among them, strontium hexaferrite cobalt iron oxide (Sr2Co2Fe12O22) is preferred over others due to its better magnetic and electrical properties than others. This material is also extensively used for the absorption of microwave radiations. This study was conducted to account for the synthesis and characterization of Sr2Co2Fe12O22 nanoparticles and to report their biocompatibility in albino mice. Nanoparticles were synthesised by normal microemulsion, XRD analysis confirmed the single and scanning electron microscopy (SEM) revealed average particle size ranged between 30 and 50 nm. Nine-week-old male mice were intraperitoneally administered with 50 mg/mL of solvent/kg body weight of strontium hexaferrite cobalt iron oxide nanoparticles for 22 days. Control group was maintained in parallel. A series of neurological tests (rota rod, light and dark box, open field and Morris water maze) were conducted in both groups. Blood samples were collected from direct cardiac puncture, and parameters of complete blood count, serum biochemical parameters and antioxidant were determined in liver and brain tissues of all subjects. Analysis of result revealed that all studied neurological test performances varied nonsignificantly (P > 0.05) between the two treatments except clockwise rotations during open field test that were significantly reduced (P = 0.05) in Strontium hexaferrite Cobalt Iron Oxide nanoparticle-treated male albino mice than in the control group. All studied complete blood count and serum parameters varied nonsignificantly (P > 0.05) between two treatments. It was observed that superoxide dismutase concentration was significantly higher (P = 0.05) in the liver of nanoparticle-treated male mice. In conclusion, we are reporting that applied dose of strontium hexaferrite cobalt iron oxide nanoparticles is affecting the exploratory behaviour and antioxidant metabolites of male albino mice

A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin Benth

As is well known, plant products have been increasingly utilized in the pharmaceutical industry in recent years. By combining conventional techniques and modern methodology, the future of phytomedicines appears promising. Pogostemon Cablin (patchouli) is an important herb used frequently in the fragrance industries and has various therapeutic benefits. Traditional medicine has long used the essential oil of patchouli (P. cablin) as a flavoring agent recognized by the FDA. This is a gold mine for battling pathogens in China and India. In recent years, this plant has seen a significant surge in use, and approximately 90% of the world’s patchouli oil is produced by Indonesia. In traditional therapies, it is used for the treatment of colds, fever, vomiting, headaches, and stomachaches. Patchouli oil is used in curing many diseases and in aromatherapy to treat depression and stress, soothe nerves, regulate appetite, and enhance sexual attraction. More than 140 substances, including alcohols, terpenoids, flavonoids, organic acids, phytosterols, lignins, aldehydes, alkaloids, and glycosides, have been identified in P. cablin. Pachypodol (C18H16O7) is an important bioactive compound found in P. cablin. Pachypodol (C18H16O7) and many other biologically essential chemicals have been separated from the leaves of P. cablin and many other medicinally significant plants using repeated column chromatography on silica gel. Pachypodol’s bioactive potential has been shown by a variety of assays and methodologies. It has been found to have a number of biological activities, including anti-inflammatory, antioxidant, anti-mutagenic, antimicrobial, antidepressant, anticancer, antiemetic, antiviral, and cytotoxic ones. The current study, which is based on the currently available scientific literature, intends to close the knowledge gap regarding the pharmacological effects of patchouli essential oil and pachypodol, a key bioactive molecule found in this plant

Recombination analyses of cotton leaf curl geminiviruses with the recombination detection program (RDP-4).

<p>The diversification of viruses infecting cotton occurred from recombination of Cotton leaf curl Multan virus (CLCuMuV) and Cotton leaf curl Kokharan virus (CLCuKoV). CLCuMuV-AY765254, Shadadpur strain, Burewala strain, and Rajasthan strains are mainly recombinants for CLCuKoV and CLCuMuV. However, cotton leaf curl Alabad virus (CLCuAlV) and CLCuMuV-AY765257 are recombinants between Bhendi yellow vein mosaic virus (BYVMV) and an unknown parent.</p

Pakistan and India are centers for diversity for cotton leaf curl disease in Asia.

<p>The disease was first reported in Pakistan and later appeared in India and China. Introduction of Cotton leaf curl Multan virus to the Philippines is a recent occurence and marks the capability of the disease to spread in very far off places from the center of diversity. The major areas in which CLCuMuV was found are shown with red circles. CLCuGeV is spreading worldwide through infection of cotton and okra plants. Currently, it is found in 11 countries (marked with pink colored circles) and is spreading from North Africa to rest of the world.</p

Nucleotide identity percentages for Multan isolates from Asia.

<p>Nucleotide identity percentages for Multan isolates from Asia.</p