The Health Consequences of Urbanization in Nepal: Perspectives from a Participatory Photo Project with Recent Rural-Urban Migrants

What new challenges to health do recent rural-to-urban migrants in Nepal face? How do newly urbanized individuals navigate and seek healthcare in the city? This photo essay offers a glimpse of the answers to these questions from the perspective of newly urbanized people living in Kirtipur and Pokhara, two rapidly growing urban areas in Nepal. It draws on a nine-month participatory study which used participatory photography, amongst other methods, to better understand the health opportunities and risks faced by new rural-urban migrants. All photographs presented in this essay were taken and selected by research participants and are accompanied by their narrations of what these images represent to them. Consequently, this essay provides insights into how the newly urbanized themselves understand threats to their health, and how they understand the urban health system they are confronted with as service users

Ribonucleotide Reductases from Bifidobacteria Contain Multiple Conserved Indels Distinguishing Them from All Other Organisms: In Silico Analysis of the Possible Role of a 43 aa Bifidobacteria-Specific Insert in the Class III RNR Homolog

Bifidobacteria comprises an important group/order of bacteria whose members have widespread usage in the food and health industry due to their health-promoting activity in the human gastrointestinal tract. However, little is known about the underlying molecular properties that are responsible for the probiotic effects of these bacteria. The enzyme ribonucleotide reductase (RNR) plays a key role in all organisms by reducing nucleoside di- or tri- phosphates into corresponding deoxyribose derivatives required for DNA synthesis, and RNR homologs belonging to classes I and III are present in either most or all Bifidobacteriales. Comparative analyses of these RNR homologs have identified several novel sequence features in the forms of conserved signature indels (CSIs) that are exclusively found in bifidobacterial RNRs. Specifically, in the large subunit of the aerobic class Ib RNR, three CSIs have been identified that are uniquely found in the Bifidobacteriales homologs. Similarly, the large subunit of the anaerobic class III RNR contains five CSIs that are also distinctive characteristics of bifidobacteria. Phylogenetic analyses indicate that these CSIs were introduced in a common ancestor of the Bifidobacteriales and retained by all descendants, likely due to their conferring advantageous functional roles. The identified CSIs in the bifidobacterial RNR homologs provide useful tools for further exploration of the novel functional aspects of these important enzymes that are exclusive to these bacteria. We also report here the results of homology modeling studies, which indicate that most of the bifidobacteria-specific CSIs are located within the surface loops of the RNRs, and of these, a large 43 amino acid insert in the class III RNR homolog forms an extension of the allosteric regulatory site known to be essential for protein function. Preliminary docking studies suggest that this large CSI may be playing a role in enhancing the stability of the RNR dimer complex. The possible significances of the identified CSIs, as well as the distribution of RNR homologs in the Bifidobacteriales, are discussed

Determinants affecting utilisation of health services and treatment for children under-5 in rural Nepali health centres: a cross-sectional study

Background Large inequalities in child health remain in Nepal, with caste, ethnicity and sex being major determinants of deprivation and negative outcomes. The purpose of this study was to explore whether key demographics of under 5s were associated with health seeking behaviours, utilisation of health care, and treatment received. Methods Data came from Integrated Management of Neonatal & Childhood Illness (IMNCI) records of 23 health centres across five districts. After digitising the paper records, the data was analysed by district, caste/ethnicity, sex, and age to investigate differences in the time taken to present at a health facility after the onset of symptoms of ARI, diarrhoea and fever; accuracy of diagnosis for pneumonia; and whether the correct treatment was prescribed for pneumonia as per IMNCI guidelines. Results From 116 register books spanning 23 health centres, 30,730 child patient records were considered for analysis. The median age of attendance was 18 months (Inter-Quartile Range = 10, 32), while were more male children that attended (55.7% vs. 44.3% for females). There were statistically significant differences for the time taken to attend a health centre between different districts for ARI, diarrhoea and fever, with children in the remote Humla and Mugu districts taking significantly longer to present at a health facility after the onset of symptoms (all p  Conclusion Significant demographic differences were found based on ethnicity, sex, and district when examining health seeking behaviours for ARI, diarrhoea, and fever. Significant associations were seen for these same factors when exploring accuracy of diagnoses of pneumonia, but not for treatment. This study has emphasised the importance of a digitalised healthcare system, where inequalities can be identified without the reliance on anecdotal evidence

Proceedings of International Conference on Applied Mathematics & Computational Sciences

This proceedings contain articles of the various research ideas of the academic community and practitioners presented at the International Conference on Applied Mathematics & Computational Sciences (ICAMCS 2019). ICAMCS2019 aimed to provide a platform to discuss ideas, issues, challenges, findings, opportunities, and applications of Applied Mathematics and Computational Sciences in various fields. It is a great privilege for us to present the proceedings of ICAMCS2019 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. Conference Title: International Conference on Applied Mathematics & Computational SciencesConference Acronym: ICAMCS-2019Conference Date: 17-19 October, 2019Conference Location: DIT University, DehradunConference Organizers: DIT University, Dehradun, Indi