Electronic Noise of a Single Skyrmion

To enable the practical use of skyrmion-based devices, it is essential to achieve a balance between energy efficiency and thermal stability, while also ensuring reliable electrical detection against noise. Understanding how a skyrmion interacts with material disorder and external perturbations is thus essential. Here we investigate the electronic noise of a single skyrmion under the influence of thermal fluctuations and spin currents in a magnetic thin film. We detect the thermally induced noise with a 1/f signature in the strong pinning regime but a random telegraph noise in the intermediate pinning regime. Both the thermally dominated and current-induced telegraph-like signals are detected in the weak pinning regime. Our results provide a comprehensive electronic noise picture of a single skyrmion, demonstrating the potential of noise fluctuation as a valuable tool for characterizing the pinning condition of a skyrmion. These insights could also aid in the development of low-noise and reliable skyrmion-based devices

Macroscopic Strings and "Quirks" at Colliders

We consider extensions of the standard model containing additional heavy particles ("quirks") charged under a new unbroken non-abelian gauge group as well as the standard model. We assume that the quirk mass m is in the phenomenologically interesting range 100 GeV--TeV, and that the new gauge group gets strong at a scale Lambda < m. In this case breaking of strings is exponentially suppressed, and quirk production results in strings that are long compared to 1/Lambda. The existence of these long stable strings leads to highly exotic events at colliders. For 100 eV < Lambda < keV the strings are macroscopic, giving rise to events with two separated quirk tracks with measurable curvature toward each other due to the string interaction. For keV < Lambda < MeV the typical strings are mesoscopic: too small to resolve in the detector, but large compared to atomic scales. In this case, the bound state appears as a single particle, but its mass is the invariant mass of a quirk pair, which has an event-by-event distribution. For MeV < Lambda < m the strings are microscopic, and the quirks annihilate promptly within the detector. For colored quirks, this can lead to hadronic fireball events with 10^3 hadrons with energy of order GeV emitted in conjunction with hard decay products from the final annihilation.Comment: Added discussion of photon-jet decay, fixed minor typo

May Measurement Month 2017 blood pressure screening: findings from Malaysia—South-East Asia and Australasia

Elevated blood pressure (BP) is a growing burden worldwide, leading to over 10 million deaths each year. However there are still many individuals, particularly in many countries in Asia, who have poor BP control. In Malaysia, less than two-fifths have achieved BP control. We participated in BP screening in Malaysia in conjunc- tion with the May Measurement Month 2017 (MMM17), a global initiative by the International Society of Hypertension (ISH) aimed at screening more individuals for earlier detection of hypertension. A nationwide screening of adults aged 18 was carried out through health campaigns at clinics, hospitals, during family day events, and charity runs from 1 April 2017 to 31 May 2017 in 42 centres. We used the detailed protocol provided by ISH for data collection. A total of 4116 individuals were screened during MMM17. After multiple imputation, 32.4% (n1⁄41317/4059) had hypertension. Out of this, 63.9% (842/1317) of those with hypertension were on treatment. Of individuals receiving antihypertensive medication with an imputed BP, 59.5% (n1⁄4496/834) of them had controlled BP. MMM17 was the largest organized BP screening campaign undertaken by health profes- sionals in Malaysia. This study identified that 32.4% of screened individuals had hypertension and 59.5% individu- als with treated hypertension had achieved BP control

Dark matter in supersymmetric models with axino LSP in Randall-Sundrum II brane model

The axino dark matter hypothesis in RSII brane model is studied. Within the framework of CMSSM we assume that the lightest neutralino or stau is the NLSP, and that the axino production has a single contribution from the NLSP decay. It is found that the axino can play the role of dark matter in the universe and we determine what the axino mass should be for different values of the five-dimensional Planck mass. An upper bound is obtained for the latterComment: 12 pages,3 figures, accepted in JHE

Loss of Heterozygosity on Chromosomes 3p, 8p, 9p and 17p in the Progression of Squamous Cell Carcinoma of the Larynx

Previous molecular genetic studies of laryngeal squamous cell carcinoma (SCC)have shown certain chromosomal regions with recurring alterations. But studies of sequential molecular alterations and genetic progression model of laryngeal SCC have not been clearly defined. To identify the chromosomal alterations associated with the carcinogenesis of laryngeal SCC, we analyzed genomic DNA from microdissected squamous metaplasia, squamous dysplasia, invasive SCC, and metastatic carcinoma samples from 22 laryngeal SCC patients for loss of heterozygosity (LOH) at microsatellite loci. Ten microsatellite markers on chromosome 3p, 8p, 9p, and 17p were used. LOH at 9p21 was observed in the all stages including squamous metaplasia, squamous dysplasia, invasive SCC and metastatic carcinoma. LOH at 17p13.1, 3p25 and 3p14.2 was observed from the squamous dysplasia, invasive SCC and metastatic carcinoma. LOH at 8p21.3-p22 was observed mainly from the invasive SCC and metastatic carcinoma. The results suggest that 9p21 in the early event, 17p13.1, 3p25 and 3p14.2 in the intermediate event and 8p21.3-p22 in the late event may be involved in the laryngeal carcinogenesis

Mechanosensitive activation of K+ channel via phospholipase C-induced depletion of phosphatidylinositol 4,5-bisphosphate in B lymphocytes

In various types of cells mechanical stimulation of the plasma membrane activates phospholipase C (PLC). However, the regulation of ion channels via mechanosensitive degradation of phosphatidylinositol 4,5-bisphosphate (PIP(2)) is not known yet. The mouse B cells express large conductance background K(+) channels (LK(bg)) that are inhibited by PIP(2). In inside-out patch clamp studies, the application of MgATP (1 mm) also inhibited LK(bg) due to the generation of PIP(2) by phosphoinositide (PI)-kinases. In the presence of MgATP, membrane stretch induced by negative pipette pressure activated LK(bg), which was antagonized by PIP(2) (> 1 microm) or higher concentration of MgATP (5 mm). The inhibition by PIP(2) was partially reversible. However, the application of methyl-beta-cyclodextrin, a cholesterol scavenger disrupting lipid rafts, induced the full recovery of LK(bg) activity and facilitated the activation by stretch. In cell-attached patches, LK(bg) were activated by hypotonic swelling of B cells as well as by negative pressure. The mechano-activation of LK(bg) was blocked by U73122, a PLC inhibitor. Neither actin depolymerization nor the inhibition of lipid phosphatase blocked the mechanical effects. Direct stimulation of PLC by m-3M3FBS or by cross-linking IgM-type B cell receptors activated LK(bg). Western blot analysis and confocal microscopy showed that the hypotonic swelling of WEHI-231 induces tyrosine phosphorylation of PLCgamma2 and PIP(2) hydrolysis of plasma membrane. The time dependence of PIP(2) hydrolysis and LK(bg) activation were similar. The presence of LK(bg) and their stretch sensitivity were also proven in fresh isolated mice splenic B cells. From the above results, we propose a novel mechanism of stretch-dependent ion channel activation, namely, that the degradation of PIP(2) caused by stretch-activated PLC releases LK(bg) from the tonic inhibition by PIP(2)