Reproductive biology of Rachycentron canadum in the Persian Gulf (Hormozgan Province waters)

We collected 478 specimens of Cobia, Rachycentron canadum, from Hormozgan province waters during October 2005 till September 2006, and studied reproductive parameters such as spawning season, sex ratio, maturity stages, fecundity and ova diameter. The maturity and spawning season were investigated through macroscopic and microscopic (ovarians histology) observation. Studying average gonadosomatic index (GSI), the percent of maturity stages and ova diameter average changes revealed that the spawning occurred from July to the beginning of September

Generalized coupled common fixed point results in partially ordered A-metric spaces

Sedghi et al. (Mat. Vesn. 64(3):258-266, 2012) introduced the notion of a S-metric as a generalized metric in 3-tuples S : X3→[0,∞), where X is a nonempty set. The aim of this paper is to introduce the concept of an n-tuple metric A : Xn→[0,∞) and to study its basic topological properties. We also prove some generalized coupled common fixed point theorems for mixed weakly monotone maps in partially ordered A-metric spaces. Some examples are presented to support the results proved herein. Our results generalize and extend various results in the existing literature.http://link.springer.com/journal/11784am201

Decline in peripheral blood NKG2D+CD3+CD56+ NKT cells in metastatic colorectal cancer patients

OBJECTIVE: Colorectal cancer (CRC) is one of the main causes of cancer deaths in the world. This cancer can be divided into non-metastatic and metastatic CRC stages. CD3+CD56+ NKT cell subsets are a minor T cell subset in peripheral blood and conduct the killing of tumor cells in direct manner. Little is obvious about levels and surface markers of these cells such as NKG2D in different cancers, especially in CRC. METHODS: We included 15 non-metastatic (low-grade), 11 non-metastatic (high-grade), 10 metastatic colorectal cancer patients and 18 healthy controls. The percentages of CD3+CD56+ NKT cells and NKG2D+CD56+ NKT cells from samples were analyzed by flow cytometry in peripheral blood mononuclear cells (PBMCs) of samples. RESULTS: We found that there was a significantly lower number of NKG2D+CD3+CD56+ cells in peripheral blood of patients with metastatic colorectal cancer compared with normal controls (77.53 ± 5.79 vs 90.74 ± 9.84 ; p < 0.01). CONCLUSION: The fact that frequency of NKG2D+CD56+ NKT cells was significantly lower in patients with metastatic colorectal cancer compared to healthy controls strengthens the hypothesis that NKT cells can play a substantial role in the protection against human colorectal cancer, and this opens up avenues for novel studies about elucidating the other aspects of tumor surveillance in CRC progression and immunotherapy

Special Libraries, June 1921

Volume 12, Issue 6https://scholarworks.sjsu.edu/sla_sl_1921/1005/thumbnail.jp

The CMS Fast Beam Condition Monitor for HL-LHC

The high-luminosity upgrade of the LHC brings unprecedented requirements for real-time and precision bunch-by-bunch online luminosity measurement and beam-induced background monitoring. A key component of the CMS Beam Radiation, Instrumentation and Luminosity system is a stand-alone luminometer, the Fast Beam Condition Monitor (FBCM), which is fully independent from the CMS central trigger and data acquisition services and able to operate at all times with a triggerless readout. FBCM utilizes a dedicated front-end application-specific integrated circuit (ASIC) to amplify the signals from CO$_2$-cooled silicon-pad sensors with a timing resolution of a few nanoseconds, which enables the measurement of the beam-induced background. FBCM uses a modular design with two half-disks of twelve modules at each end of CMS, with four service modules placed close to the outer edge to reduce radiation-induced aging. The electronics system design adapts several components from the CMS Tracker for power, control and read-out functionalities. The dedicated FBCM23 ASIC contains six channels and adjustable shaping time to optimize the noise with regards to sensor leakage current. Each ASIC channel outputs a single binary high-speed asynchronous signal carrying time-of-arrival and time-over-threshold information. The chip output signal is digitized, encoded and sent via a radiation-hard gigabit transceiver and an optical link to the back-end electronics for analysis. This paper reports on the updated design of the FBCM detector and the ongoing testing program.Comment: 16th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD23) 2023 Sept 25-29 Siena, Ital

An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy

The extracellular matrix comprises a network of macromolecules such as collagens, proteoglycans and glycoproteins. VWA1 (von Willebrand factor A domain containing 1) encodes a component of the extracellular matrix that interacts with perlecan/collagen VI, appears to be involved in stabilizing extracellular matrix structures, and demonstrates high expression levels in tibial nerve. Vwa1-deficient mice manifest with abnormal peripheral nerve structure/function; however, VWA1 variants have not previously been associated with human disease. By interrogating the genome sequences of 74 180 individuals from the 100K Genomes Project in combination with international gene-matching efforts and targeted sequencing, we identified 17 individuals from 15 families with an autosomal-recessive, non-length dependent, hereditary motor neuropathy and rare biallelic variants in VWA1. A single disease-associated allele p.(G25Rfs*74), a 10-bp repeat expansion, was observed in 14/15 families and was homozygous in 10/15. Given an allele frequency in European populations approaching 1/1000, the seven unrelated homozygote individuals ascertained from the 100K Genomes Project represents a substantial enrichment above expected. Haplotype analysis identified a shared 220 kb region suggesting that this founder mutation arose >7000 years ago. A wide age-range of patients (6–83 years) helped delineate the clinical phenotype over time. The commonest disease presentation in the cohort was an early-onset (mean 2.0 ± 1.4 years) non-length-dependent axonal hereditary motor neuropathy, confirmed on electrophysiology, which will have to be differentiated from other predominantly or pure motor neuropathies and neuronopathies. Because of slow disease progression, ambulation was largely preserved. Neurophysiology, muscle histopathology, and muscle MRI findings typically revealed clear neurogenic changes with single isolated cases displaying additional myopathic process. We speculate that a few findings of myopathic changes might be secondary to chronic denervation rather than indicating an additional myopathic disease process. Duplex reverse transcription polymerase chain reaction and immunoblotting using patient fibroblasts revealed that the founder allele results in partial nonsense mediated decay and an absence of detectable protein. CRISPR and morpholino vwa1 modelling in zebrafish demonstrated reductions in motor neuron axonal growth, synaptic formation in the skeletal muscles and locomotive behaviour. In summary, we estimate that biallelic variants in VWA1 may be responsible for up to 1% of unexplained hereditary motor neuropathy cases in Europeans. The detailed clinical characterization provided here will facilitate targeted testing on suitable patient cohorts. This novel disease gene may have previously evaded detection because of high GC content, consequential low coverage and computational difficulties associated with robustly detecting repeat-expansions. Reviewing previously unsolved exomes using lower QC filters may generate further diagnoses