2 research outputs found
Endothelial dysfunction of vessels at ANCA-associated systemic vasculitis
Aim. To evaluate clinical-pathogenetic relationship between systemic vasculitis associated with anti-neutrophil cytoplasmic antibodies and vascular endothelial dysfunction. Materials and methods. In order to clarify relationships between clinical course of systemic vasculitis with the state of the endothelial vascular function the indicators of endothelial function of vessels in blood (the levels of endothelin-1, thromboxane A2, homocysteine, prostacyclins, nitrites, cyclic guanosine monophosphate) were studied with biochemical and immunoenzyme methods in 129 patients (76 - with microscopic polyangiitis, 26 β with Wegener's granulomatous polyangiitis and 27 - with eosinophilic polyangiitis Churg-Strauss). Results. The imbalance of levels of vasoconstrictors and vasodilators was determined. It was manifested by increased concentrations of endothelin-1 and nitrites in the background of the the amount of prostacyclin and homocysteine reduce.
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Conclusions. The abnormality of endothelial dysfunction of vessels in systemic vasculitis were involved in the vasculitis pathogenesis
ΠΠ½Π΄ΠΎΡΠ΅Π»ΡΠ°Π»ΡΠ½Π° Π΄ΠΈΡΡΡΠ½ΠΊΡΡΡ ΡΡΠ΄ΠΈΠ½ ΠΏΡΠΈ ANCA-Π°ΡΠΎΡΡΠΉΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΈΡ Π²Π°ΡΠΊΡΠ»ΡΡΠ°Ρ
Aim. To evaluate clinical-pathogenetic relationship between systemic vasculitis associated with anti-neutrophil cytoplasmic antibodies and vascular endothelial dysfunction. Materials and methods. In order to clarify relationships between clinical course of systemic vasculitis with the state of the endothelial vascular function the indicators of endothelial function of vessels in blood (the levels of endothelin-1, thromboxane A2, homocysteine, prostacyclins, nitrites, cyclic guanosine monophosphate) were studied with biochemical and immunoenzyme methods in 129 patients (76 - with microscopic polyangiitis, 26 β with Wegener's granulomatous polyangiitis and 27 - with eosinophilic polyangiitis Churg-Strauss). Results. The imbalance of levels of vasoconstrictors and vasodilators was determined. It was manifested by increased concentrations of endothelin-1 and nitrites in the background of the the amount of prostacyclin and homocysteine reduce.Conclusions. The abnormality of endothelial dysfunction of vessels in systemic vasculitis were involved in the vasculitis pathogenesis.Β ΠΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠΌΠΈ Π²Π°ΡΠΊΡΠ»ΠΈΡΠ°ΠΌΠΈ, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Ρ Π°Π½ΡΠΈΠ½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΡΠ½ΡΠΌΠΈ ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ, ΠΈ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠ΅ΠΉ ΡΠΎΡΡΠ΄ΠΎΠ² ΠΈΠ·ΡΡΠ΅Π½Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ. Π‘ ΡΠ΅Π»ΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ Π²Π·Π°ΠΈΠΌΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΡ
Π²Π°ΡΠΊΡΠ»ΠΈΡΠΎΠ² Ρ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠΎΡΡΠ΄ΠΎΠ² Ρ 129 Π±ΠΎΠ»ΡΠ½ΡΡ
(76 Ρ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΠ»ΠΈΠ°Π½Π³ΠΈΠΈΡΠΎΠΌ, 26 Ρ Π³ΡΠ°Π½ΡΠ»ΡΠΌΠ°ΡΠΎΠ·Π½ΡΠΌ ΠΏΠΎΠ»ΠΈΠ°Π½Π³ΠΈΠΈΡΠΎΠΌ ΠΠ΅Π³Π΅Π½Π΅ΡΠ° ΠΈ 27 Ρ ΡΠΎΠ·ΠΈΠ½ΠΎΡΠΈΠ»ΡΠ½ΡΠΌ ΠΏΠΎΠ»ΠΈΠ°Π½Π³ΠΈΠΈΡΠΎΠΌ Π§Π΅ΡΠ΄ΠΆΠ°-Π‘ΡΡΠΎΡΡ) Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΈΠ·ΡΡΠ΅Π½Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π² ΠΊΡΠΎΠ²ΠΈ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠΎΡΡΠ΄ΠΎΠ² (ΡΡΠΎΠ²Π½ΠΈ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ½Π°-1, ΡΡΠΎΠΌΠ±ΠΎΠΊΡΠ°Π½Π°-Π2, Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π°, ΠΏΡΠΎΡΡΠ°ΡΠΈΠΊΠ»ΠΈΠ½Π°, Π½ΠΈΡΡΠΈΡΠΎΠ², ΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π³ΡΠ°Π½ΠΎΠ·ΠΈΠ½ΠΌΠΎΠ½ΠΎΡΠΎΡΡΠ°ΡΠ°). Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ Π΄ΠΈΡΠ±Π°Π»Π°Π½Ρ ΡΡΠΎΠ²Π½Π΅ΠΉ Π²Π°Π·ΠΎΠΊΠΎΠ½ΡΡΡΠΈΠΊΡΠΎΡΠΎΠ² ΠΈ Π²Π°Π·ΠΎΠ΄ΠΈΠ»Π°ΡΠ°ΡΠΎΡΠΎΠ² Π² ΠΊΡΠΎΠ²ΠΈ, ΡΡΠΎ ΠΏΡΠΎΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ½Π°-1 ΠΈ Π½ΠΈΡΡΠΈΡΠΎΠ² Π½Π° ΡΠΎΠ½Π΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΏΡΠΎΡΡΠ°ΡΠΈΠΊΠ»ΠΈΠ½Π° ΠΈ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π°. ΠΡΠΎ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎ Π½Π°ΡΡΡΠ΅Π½ΠΈΡΡ
ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠΎΡΡΠ΄ΠΎΠ² ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΡ
Π²Π°ΡΠΊΡΠ»ΠΈΡΠ°Ρ
, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΡΠ°ΡΡΠ²ΡΡΡ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΡΡΡΠΎΠ΅Π½ΠΈΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ.ΠΠ»ΡΠ½ΡΠΊΠΎ-ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ½Ρ Π·Π²'ΡΠ·ΠΊΠΈ ΠΌΡΠΆ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΈΠΌΠΈ Π²Π°ΡΠΊΡΠ»ΡΡΠ°ΠΌΠΈ, ΡΠΎ Π°ΡΠΎΡΡΡΡΡΡΡΡ Π· Π°Π½ΡΠΈΠ½Π΅ΠΉΡΡΠΎΡΡΠ»ΡΠ½ΠΈΠΌΠΈ ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ½ΠΈΠΌΠΈ Π°Π½ΡΠΈΡΡΠ»Π°ΠΌΠΈ, Ρ Π΅Π½Π΄ΠΎΡΠ΅Π»ΡΠ°Π»ΡΠ½ΠΎΡ Π΄ΠΈΡΡΡΠ½ΠΊΡΡΡΡ ΡΡΠ΄ΠΈΠ½ Π²ΠΈΠ²ΡΠ΅Π½ΠΎ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠ½ΡΠΎ. Π ΠΌΠ΅ΡΠΎΡ ΠΎΡΡΠ½ΡΠ²Π°Π½Π½Ρ Π²Π·Π°ΡΠΌΠΎΠ²ΡΠ΄Π½ΠΎΡΠΈΠ½ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΡ ΠΏΠ΅ΡΠ΅Π±ΡΠ³Ρ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΈΡ
Π²Π°ΡΠΊΡΠ»ΡΡΡΠ² Π·Ρ ΡΡΠ°Π½ΠΎΠΌ Π΅Π½Π΄ΠΎΡΠ΅Π»ΡΠ°Π»ΡΠ½ΠΎΡ ΡΡΠ½ΠΊΡΡΡ ΡΡΠ΄ΠΈΠ½ Ρ 129 Ρ
Π²ΠΎΡΠΈΡ
(76 ΡΠ· ΠΌΡΠΊΡΠΎΡΠΊΠΎΠΏΡΡΠ½ΠΈΠΌ ΠΏΠΎΠ»ΡΠ°Π½Π³ΡΡΡΠΎΠΌ, 26 ΡΠ· Π³ΡΠ°Π½ΡΠ»Π΅ΠΌΠ°ΡΠΎΠ·Π½ΠΈΠΌ ΠΏΠΎΠ»ΡΠ°Π½Π³ΡΡΡΠΎΠΌ ΠΠ΅Π³Π΅Π½Π΅ΡΠ° Ρ 27 Π· Π΅ΠΎΠ·ΠΈΠ½ΠΎΡΡΠ»ΡΠ½ΠΈΠΌ ΠΏΠΎΠ»ΡΠ°Π½Π³ΡΡΡΠΎΠΌ Π§Π΅ΡΠ΄ΠΆΠ°-Π‘ΡΡΠΎΡ) Π±ΡΠΎΡ
ΡΠΌΡΡΠ½ΠΈΠΌ ΡΠ° ΡΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ Π²ΠΈΠ²ΡΠΈΠ»ΠΈ ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠΈ Ρ ΠΊΡΠΎΠ²Ρ Π΅Π½Π΄ΠΎΡΠ΅Π»ΡΠ°Π»ΡΠ½ΠΎΡ ΡΡΠ½ΠΊΡΡΡ ΡΡΠ΄ΠΈΠ½ (ΡΡΠ²Π½Ρ Π΅Π½Π΄ΠΎΡΠ΅Π»ΡΠ½Ρ-1, ΡΡΠΎΠΌΠ±ΠΎΠΊΡΠ°Π½Ρ-Π2, Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΡΠ½Ρ, ΠΏΡΠΎΡΡΠ°ΡΠΈΠΊΠ»ΡΠ½Ρ, Π½ΡΡΡΠΈΡΡΠ², ΡΠΈΠΊΠ»ΡΡΠ½ΠΎΠ³ΠΎ Π³ΡΠ°Π½ΠΎΠ·ΠΈΠ½ΠΌΠΎΠ½ΠΎΡΠΎΡΡΠ°ΡΡ). ΠΡΡΠ°Π½ΠΎΠ²ΠΈΠ»ΠΈ Π΄ΠΈΡΠ±Π°Π»Π°Π½Ρ ΡΡΠ²Π½ΡΠ² Π²Π°Π·ΠΎΠΊΠΎΠ½ΡΡΡΠΈΠΊΡΠΎΡΡΠ² ΠΉ Π²Π°Π·ΠΎΠ΄ΠΈΠ»Π°ΡΠ°ΡΠΎΡΡΠ² Ρ ΠΊΡΠΎΠ²Ρ, ΡΠΎ Π²ΠΈΡΠ²Π»ΡΡΡΡΡΡ ΠΏΡΠ΄Π²ΠΈΡΠ΅Π½Π½ΡΠΌ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΠΉ Π΅Π½Π΄ΠΎΡΠ΅Π»ΡΠ½Ρ-1 Ρ Π½ΡΡΡΠΈΡΡΠ² Π½Π° ΡΠ»Ρ Π·ΠΌΠ΅Π½ΡΠ΅Π½Π½Ρ Π²ΠΌΡΡΡΡ ΠΏΡΠΎΡΡΠ°ΡΠΈΠΊΠ»ΡΠ½Ρ ΡΠ° Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΡΠ½Ρ. Π¦Π΅ ΡΠ²ΡΠ΄ΡΠΈΡΡ ΠΏΡΠΎ ΠΏΠΎΡΡΡΠ΅Π½Π½Ρ Π΅Π½Π΄ΠΎΡΠ΅Π»ΡΠ°Π»ΡΠ½ΠΎΡ ΡΡΠ½ΠΊΡΡΡ ΡΡΠ΄ΠΈΠ½ ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΈΡ
Π²Π°ΡΠΊΡΠ»ΡΡΠ°Ρ
, ΠΊΠΎΡΡΡ Π±Π΅ΡΡΡΡ ΡΡΠ°ΡΡΡ Ρ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ½ΠΈΡ
ΠΏΠΎΠ±ΡΠ΄ΠΎΠ²Π°Ρ
Π·Π°Ρ
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