LIVER AND SYSTEMIC DISEASES

The liver which is the largest organ in the body, performs many different functions, such as processing, synthesizing, storing, transporting and excreting multiple substances as well as detoxificating of endogenous or exogenous substances. Therefore, the liver as a main organ for all these functions may be affected by systemic diseases, and altered results could be seen in liver tests and clinical findings. In this paper, the relationship between liver and systemic diseases are reviewed

ROUTINE TESTS OF THE LIVER

Laboratory investigations reflecting liver disease are commonly termed as liver function tests. Although this term is misnomer, it has been traditionally continued to use by clinicians. Meanwhile, some terms such as liver panels, liver biochemistries or hepatic profiles have been used. An alternative term is routine tests of the liver. This article reviews routine tests for liver disease including serum aminotransferases, alkaline phosphatase, gamma glutamyl transferase, bilirubin, albumin and prothrombin time

Two Leptospirosis Cases Presented with Fever, Anemia, and Hepatosplenomegaly

Leptospirosis affects humans in both urban and rural areas, and in temperate and tropical climates. The spectrum of human disease caused by leptospires is extremely wide, ranging from subclinical infection to a severe syndrome of multiorgan infection with high mortality. However, the great majority of the infection has either subclinical or very mild illness; hereby, most patients do not seek medical attention. We herein present two patients with leptospirosis hospitalized due to unexplained fever, anemia, and hepatosplenomegaly

Mutation analysis of PRSS1, SPINK1 and CFTR gene in patients with alcoholic and idiopathic chronic pancreatitis: A single center study

Background/Aims: A relation between some genetic mutations and chronic pancreatitis (CP) has been reported. However, the relation of genetic mutation to alcoholic CP (ACP) and idiopathic CP (ICP) still remains controversial. In this study, we investigated the prevalence of protease serine 1 (PRSS1), serine protease inhibitor, Kazal type 1 (SPINK1) SPINK1 and cystic fibrosis transmembrane conductance regulator (CFTR) mutations in ACP and ICP patients in Turkey

Serum autoantibody positivity and its impact on the treatment response of the genotype 1 chronic hepatitis C.

Background: Autoantibody positivity is a common finding in chronic hepatitis C infection. The data about the clinical and prognostic significance of the presence of these autoantibodies is still controversial. The aim of this study is to investigate the clinical significance of the presence of autoantibodies on the treatment response of the genotype 1 chronic hepatitis C

Nonalcoholic Fatty Liver Disease and Familial Mediterranean Fever: Are They Related?

Introduction Familial Mediterranean fever (FMF) is a periodic febrile disease characterized by acute recurrent episodes of serositis. Liver disease is not considered a part of the spectrum of clinical manifestations of FMF

Prevalence of osteoporosis, osteopenia and vitamin d deficiency in cirrhotic patients.

Background and aims: Osteoporosis (OP) is a major complication of cirrhosis. It can cause morbidity and mortality due to an increased fracture risk. The aim of this study is to determine the frequency of OP and vitamin D deficiency among patients with cirrhosis and to identify the risk factors associated with OP in these patients

Five-year results of oral antiviral therapy in HBeAg-negative chronic Hepatitis B

Background/Aims: Several guidelines recommend the use of tenofovir or entecavir as the first-line treatment for hepatitis B due to the lower resistance rates of these drugs than lamivudine, although lamivudine may still be preferred because of its low adverse effect profile and cost. It is important to know which patients might benefit from lamivudine as the first-line treatment. We aimed to assess the success rates of lamivudine, entecavir, and tenofovir, as well as the resistance rates, frequencies of HBsAg clearance, and risk factors for lamivudine resistance