Hybrid Imaging in the Assessment of Myocardial Ischemia and Viability

Myocardial ischemia results from a reduction in blood flow as a consequence of a coronary stenosis, which produces ischemia in the myocardial territories irrigated by the stenotic artery. Myocardial viability is a concept that derived from several studies in which it was observed that, even if revascularization occurred, an irreversible left ventricular contractile dysfunction remained. The terms “stunned” and “hibernating” myocardium have been traditionally associated with the viable myocardium, and many controversies still exist on the most appropriate method to assess the presence and extent of viable myocardium. During the last decades, many efforts have been made to identify the best method to determine the viability of the myocardial tissue. Due to the fact that none of the stand-alone imaging methods provide sufficient data about myocardial viability, new methods for the investigation of myocardial viability became necessary. Thus, the concept of hybrid imaging was developed, consisting in the association of different imaging techniques, finally resulting in a single image that offers all the details provided by the two isolated methods of diagnosis, therefore being more precise in regards to the identification of viable myocardium territory. This review aims to appraise the recent studies related to myocardial viability investigated with hybrid imaging

Transluminal Attenuation Gradient for the Noninvasive Assessment of Functional Significance in Coronary Artery Stenoses

Invasive and noninvasive methods currently used for imaging-based evaluation of the coronary tree reveal a high number of moderate degree coronary artery stenoses, and the decision to revascularize or not such lesions could be difficult in different clinical settings. Therefore, the need for evaluating the functional significance of such lesions appeared obvious and led to the introduction of fractional flow reserve methodology, a new tool proposed for the evaluation of the functional impact of a coronary stenosis. At the same time, new tools have been proposed for the same application, such as the transluminal attenuation gradient along a coronary artery stenosis, determined using cardiac computed angiography. The aim of this short update is to summarize the recent advances in the field of invasive and noninvasive evaluation of the functional significance of coronary artery stenoses

New Developments in Magnetic Resonance Imaging of Myocardial Diseases – Technical Aspects and Clinical Applications

Cardiac magnetic resonance imaging is an evolving imaging method that can be used in cardiovascular pathology evaluation. Technological developments have increased the clinical utility of cardiac magnetic resonance in the exploration of various cardiac abnormalities. The most important imaging techniques and their utility will be presented in this review, together with the advantages and limitations of cardiac magnetic resonance and with a brief presentation of common cardiac disorders that can be assessed by cardiac magnetic resonance including ischemic heart disease, cardiomyopathies and myocarditis

Factors Associated with Development of in Coronary Stent Restenosis — the Results of a Multislice Computed Tomography 1-year Follow-up Study

Introduction: Percutaneous coronary intervention is the first therapeutic choice in the treatment of symptomatic coronary artery disease and Multi-Slice Computed Tomography Coronary Angiography (MSCT-CA) is a new non-invasive diagnostic tool in the follow-up of these patients. The aim of our study was to evaluate the rate of in-stent restenosis (ISR), to identify the predictive factors for ISR at 1 year after PCI and to assess the progression of non-culprit lesions, using a MSCT-CA follow-up

Myocardial Fibrosis and the Risk of Recurrence in Atrial Fibrillation

Atrial fibrillation (AF) is the most frequent cardiac arrhythmia increasing the risk of stroke and mortality from heart failure. Magnetic resonance imaging was used by several authors for assessment of atrial fibrosis and to predict the rate of recurrence following AF ablation. The aim of this manuscript was to summarize the new data in the literature regarding the role of atrial fibrosis in AF imaging and the role of cardiac fibrosis in predicting AF recurrence after radio-frequency ablation

Noninvasive Assessment of Coronary Artery Disease: Fractional Flow Reserved Derived from Coronary Computed Tomography Angiography (FFRCT)

Invasive coronary angiography (ICA) completed by fractional flow reserve (FFR) assessment represents the main procedure that is performed in the decision process for coronary revascularization. Coronary Computed Tomography Angiography (CCTA) is an effective method used in the noninvasive anatomic assessment of coronary artery disease (CAD). However, CCTA tends to overestimate and does not offer hemodynamic data about the coronary lesions. Recent progresses made in the research involving computational fluid dynamics and image modeling permit the evaluation of FFRCT noninvasively, using data obtained in a standard CCTA. Studies have shown an improved precision and discrimination of FFRCT compared to CCTA for the diagnosis of significant coronary artery stenosis. In this review, we aimed to summarize the role of CCTA in CAD evaluation, the impact of FFRCT, the scientific basis of this novel method and its potential clinical applications

Association Between Severity of Peripheral Artery Disease Angio CT-derived Coronary Syntax Score in Patients with Critical Limb Ischemia

Introduction: Peripheral artery disease, a frequent consequence of atherosclerosis, is usually associated with concomitant ischaemic coronary artery disease and with a high rate of cardiovascular mortality

Computed Tomography Biomarkers of Vulnerable Coronary Plaques

An unstable plaque has a high risk of thrombosis and at the same time for a fast progression of the stenosis degree. Also, “high-risk plaque” and “thrombosis-prone plaque” are used as synonym terms for characterization of a vulnerable plaque. The imaging biomarkers for vulnerable coronary plaques are considered to be spotty calcifications, active remodeling, low-density atheroma and the presence of a ring-like attenuation pattern, also known as the napkin-ring sign. Computed cardiac tomography can determine the plaque composition by assessing the plaque density, which is measured in Hounsfield units (HU). The aim of this manuscript was to provide an update about the most frequently used biomarkers of vulnerability in a vulnerable plaque with the help of computed cardiac tomography

Computed tomography versus invasive coronary angiography:design and methods of the pragmatic randomised multicentre DISCHARGE trial

Objectives: More than 3.5 million invasive coronary angiographies (ICA) are performed in Europe annually. Approximately 2 million of these invasive procedures might be reduced by noninvasive tests because no coronary intervention is performed. Computed tomography (CT) is the most accurate noninvasive test for detection and exclusion of coronary artery disease (CAD). To investigate the comparative effectiveness of CT and ICA, we designed the European pragmatic multicentre DISCHARGE trial funded by the 7th Framework Programme of the European Union (EC-GA 603266). Methods: In this trial, patients with a low-to-intermediate pretest probability (10–60 %) of suspected CAD and a clinical indication for ICA because of stable chest pain will be randomised in a 1-to-1 ratio to CT or ICA. CT and ICA findings guide subsequent management decisions by the local heart teams according to current evidence and European guidelines. Results: Major adverse cardiovascular events (MACE) defined as cardiovascular death, myocardial infarction and stroke as a composite endpoint will be the primary outcome measure. Secondary and other outcomes include cost-effectiveness, radiation exposure, health-related quality of life (HRQoL), socioeconomic status, lifestyle, adverse events related to CT/ICA, and gender differences. Conclusions: The DISCHARGE trial will assess the comparative effectiveness of CT and ICA. Key Points: • Coronary artery disease (CAD) is a major cause of morbidity and mortality. • Invasive coronary angiography (ICA) is the reference standard for detection of CAD. • Noninvasive computed tomography angiography excludes CAD with high sensitivity. • CT may effectively reduce the approximately 2 million negative ICAs in Europe. • DISCHARGE addresses this hypothesis in patients with low-to-intermediate pretest probability for CAD.</p