3 research outputs found
Synthesis of the Privileged 8âArylmenthol Class by Radical Arylation of Isopulegol
Hydrogen atom transfer
(HAT) circumvents a disfavored FriedelâCrafts
reaction in the derivatization of the inexpensive monoterpene isopulegol.
A variety of readily prepared aryl and heteroaryl sulfonates undergo
a formal hydroarylation to form 8-arylmenthols, privileged scaffolds
for asymmetric synthesis, as typified by 8-phenylmenthol. High stereoselectivity
is observed in related systems. This use of HAT significantly extends
the chiral pool from the inexpensive monoterpene isopulegol
Synthesis of the Privileged 8âArylmenthol Class by Radical Arylation of Isopulegol
Hydrogen atom transfer
(HAT) circumvents a disfavored FriedelâCrafts
reaction in the derivatization of the inexpensive monoterpene isopulegol.
A variety of readily prepared aryl and heteroaryl sulfonates undergo
a formal hydroarylation to form 8-arylmenthols, privileged scaffolds
for asymmetric synthesis, as typified by 8-phenylmenthol. High stereoselectivity
is observed in related systems. This use of HAT significantly extends
the chiral pool from the inexpensive monoterpene isopulegol
Synthesis of the Privileged 8âArylmenthol Class by Radical Arylation of Isopulegol
Hydrogen atom transfer
(HAT) circumvents a disfavored FriedelâCrafts
reaction in the derivatization of the inexpensive monoterpene isopulegol.
A variety of readily prepared aryl and heteroaryl sulfonates undergo
a formal hydroarylation to form 8-arylmenthols, privileged scaffolds
for asymmetric synthesis, as typified by 8-phenylmenthol. High stereoselectivity
is observed in related systems. This use of HAT significantly extends
the chiral pool from the inexpensive monoterpene isopulegol