27 research outputs found

    What’s Wrong with Dodd-Frank 1502? Conflict Minerals, Civilian Livelihoods, and the Unintended Consequences of Western Advocacy- Working Paper 284

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    Although its provisions have yet to be implemented, section 1502 of the Dodd-Frank Wall Street Reform and Consumer Protection Act is already having a profound effect on the Congolese mining sector. Nicknamed “Obama’s Law” by the Congolese, section 1502 has created a de facto ban on Congolese mineral exports, put anywhere from tens of thousands up to 2 million Congolese miners out of work in the eastern Congo, and, despite ending most of the trade in Congolese conflict minerals, done little to improve the security situation or the daily lives of most Congolese. In this report, Laura Seay traces the development of section 1502 with respect to the pursuit of a conflict minerals-based strategy by U.S. advocates, examines the effects of the legislation, and recommends new courses of action to move forward in a way that both promotes accountability and transparency and allows Congolese artisanal miners to earn a living. Length: 32 pages

    Density and Dichotomous Family History Measures of Alcohol Use Disorder as Predictors of Behavioral and Neural Phenotypes: A Comparative Study Across Gender and Race/Ethnicity

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    Background: Family history (FH) is an important risk factor for the development of alcohol use disorder (AUD). A variety of dichotomous and density measures of FH have been used to predict alcohol outcomes; yet, a systematic comparison of these FH measures is lacking. We compared 4 density and 4 commonly used dichotomous FH measures and examined variations by gender and race/ethnicity in their associations with age of onset of regular drinking, parietal P3 amplitude to visual target, and likelihood of developing AUD. Methods: Data from the Collaborative Study on the Genetics of Alcoholism (COGA) were utilized to compute the density and dichotomous measures. Only subjects and their family members with DSM-5 AUD diagnostic information obtained through direct interviews using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) were included in the study. Area under receiver operating characteristic curves were used to compare the diagnostic accuracy of FH measures at classifying DSM-5 AUD diagnosis. Logistic and linear regression models were used to examine associations of FH measures with alcohol outcomes. Results: Density measures had greater diagnostic accuracy at classifying AUD diagnosis, whereas dichotomous measures presented diagnostic accuracy closer to random chance. Both dichotomous and density measures were significantly associated with likelihood of AUD, early onset of regular drinking, and low parietal P3 amplitude, but density measures presented consistently more robust associations. Further, variations in these associations were observed such that among males (vs. females) and Whites (vs. Blacks), associations of alcohol outcomes with density (vs. dichotomous) measures were greater in magnitude. Conclusions: Density (vs. dichotomous) measures seem to present more robust associations with alcohol outcomes. However, associations of dichotomous and density FH measures with different alcohol outcomes (behavioral vs. neural) varied across gender and race/ethnicity. These findings have great applicability for alcohol research examining FH of AUD

    Understanding Somali Piracy

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    Writing for Public Engagement

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    Academic research frequently speaks to current events and ongoing issues, from political protests and election events to climate change. Yet, the media often ignores academic expertise, and paywalled academic journals are inaccessible to most policy makers and the general public. How can university researchers effectively communicate our findings and ideas to audiences outside the academy? How do we ensure that our research is taken into account in public policy making processes? This workshop highlights strategies for academics who wish to engage with broad audiences of politicians, policy professionals, and general audiences. In the first part of the workshop, we will discuss effective strategies for topic identification, media outlet selection, accessible writing, and pitching to editors, from writing analytical blog posts to developing opinion-editorial pieces and policy papers. In the second part of the workshop, participants will each prepare a draft analytical blog post or op-ed and receive real-time feedback from the group. Participants are encouraged to come to the workshop with a topic they would like to write about in mind, such as a recently or soon to be published article, research findings, or informed observations relevant to a current event

    Whipping Up a New Flavor - Slides

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    A 43-year old Indian man presented with two years of progressive gait imbalance, dysarthria, and cognitive decline. Neurological exam revealed supranuclear gaze palsy with impaired downgaze and loss of OKN quick phases, impaired horizontal pursuit, ideomotor apraxia, facial and arm dystonia, foot and toe chorea, hyperreflexia, retropulsion, and gait ataxia. Neuropsychological testing suggested subcortical dementia. Brain MRI revealed multiple nonenhancing, confluent, periventricular and juxtacortical T2 hyperintensities and severe atrophy with a hummingbird sign. A paraneoplastic panel, GAD antibodies, and NMDA antibodies were negative. CSF revealed normal white blood cell count, elevated protein (81), markedly elevated IgG index and synthesis, 15 oligoclonal bands, negative paraneoplastic panel, negative Whipple's DNA PCR, and negative CJD testing (negative tau quantity and ambiguous 14-3-3, not supporting the diagnosis of CJD). Body PET-CT and EEG were normal. Treatment with high dose steroids, IVIG, and plasmapheresis were ineffective. Brain biopsy showed a hypercellular cortex and white matter with spongiosis, gliosis, and diffuse inflammatory parenchymal and meningeal infiltrate. The cortex contained numerous inflammatory nodules with neuronophagia. Overall the features were nonspecific and most suggestive of an inflammatory meningoencephalitis, such as a viral infection, autoimmune disease, or paraneoplastic process. The patient continued to deteriorate and died from sepsis six years after disease onset. An autopsy was performed.SMcomplicationsofinfection

    Whipping Up a New Flavor - Abstract

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    A 43-year old Indian man presented with two years of progressive gait imbalance, dysarthria, and cognitive decline. Neurological exam revealed supranuclear gaze palsy with impaired downgaze and loss of OKN quick phases, impaired horizontal pursuit, ideomotor apraxia, facial and arm dystonia, foot and toe chorea, hyperreflexia, retropulsion, and gait ataxia. Neuropsychological testing suggested subcortical dementia. Brain MRI revealed multiple nonenhancing, confluent, periventricular and juxtacortical T2 hyperintensities and severe atrophy with a hummingbird sign. A paraneoplastic panel, GAD antibodies, and NMDA antibodies were negative. CSF revealed normal white blood cell count, elevated protein (81), markedly elevated IgG index and synthesis, 15 oligoclonal bands, negative paraneoplastic panel, negative Whipple's DNA PCR, and negative CJD testing (negative tau quantity and ambiguous 14-3-3, not supporting the diagnosis of CJD). Body PET-CT and EEG were normal. Treatment with high dose steroids, IVIG, and plasmapheresis were ineffective. Brain biopsy showed a hypercellular cortex and white matter with spongiosis, gliosis, and diffuse inflammatory parenchymal and meningeal infiltrate. The cortex contained numerous inflammatory nodules with neuronophagia. Overall the features were nonspecific and most suggestive of an inflammatory meningoencephalitis, such as a viral infection, autoimmune disease, or paraneoplastic process. The patient continued to deteriorate and died from sepsis six years after disease onset. An autopsy was performed.SMcomplicationsofinfection
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