Community Engagement newsletter, Faculty of Veterinary Science, Autumn, May 2018

Locuming in paradise / Luke Arnot -- Real about rabies at Ribane-Laka / Sylvia-Anne Farmer, Daniel Parsons, Matthew Woods and Hendre van Zyl -- Lending a helping paw / Kgopotso Mabote -- One Health efforts in Gauteng put to the test / Lindsey Burgess, Devon Seaton and John Burgess -- Community engagement project goes viral / Andrè Els and Nydia-Lee BritsNews articles with colour photos about the various community engagement projects of the Faculty of Veterinary Science, University of Pretoria.ab201

Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics.

Induced pluripotent stem cells (iPSCs) are an established cellular system to study the impact of genetic variants in derived cell types and developmental contexts. However, in their pluripotent state, the disease impact of genetic variants is less well known. Here, we integrate data from 1,367 human iPSC lines to comprehensively map common and rare regulatory variants in human pluripotent cells. Using this population-scale resource, we report hundreds of new colocalization events for human traits specific to iPSCs, and find increased power to identify rare regulatory variants compared with somatic tissues. Finally, we demonstrate how iPSCs enable the identification of causal genes for rare diseases