3,898 research outputs found

    Effects of decision-making on the transport costs across complex networks

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    We analyze the effects of agents' decisions on the creation of congestion on a centralized network with ring-and-hub topology. We show that there are two classes of agents each displaying a distinct set of behaviours. The dynamics of the system are driven by an interplay between the formation of, and transition between, unique stable states that arise as the network is varied. We show how the flow of objects across the network can be understood in terms of the ordering and allocation of strategies. Our results show that the existence of congestion in a network is a dynamic process that is as much dependent on the agents' decisions as it is on the structure of the network itself.Comment: Special Issue on Complex Networks, edited by Dirk Helbin

    Stereo-Aware Extension of HOSE Codes

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    The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Descriptions of molecular environments have many applications in chemoinformatics, including chemical shift prediction. Hierarchically ordered spherical environment (HOSE) codes are the most popular such descriptions. We developed a method to extend these with stereochemistry information. It enables distinguishing atoms which would be considered identical in traditional HOSE codes. The use of our method is demonstrated by chemical shift predictions for molecules in the nmrshiftdb2 database. We give a full specification and an implementation

    Regulation of mediation training and education: thin end of the wedge or just a wedge?

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    With the introduction of the National Mediator Approval and Accreditation Standards this year the training and education sector of the dispute resolution market has prescribed a number of quantitative standards that must be met to produce participants eligible to become accredited. The Standards prescribe the number of role plays that students should participate in and the minimum number of hours for the course/subject. Questions considered in this presentation include: - Whether quantitative prescription is an appropriate approach and whether the proposed standards are effective in achieving the objectives of the regulation of entry into the mediation profession. - Is it appropriate that the regulatory agency prescribe teaching approaches and what implications this has for the pedagodgy/andragogy of dispute and conflict resolution subjects beyond the scope of the mediation program? - How do the standards reconcile the accreditation standards with the educational standards? - Are the education requirements sufficiently clear to ensure that objectives of the regulatory model are met and if not are the grounds for the vagueness justified? The presentation will explore issues of self-regulation and professionalization of the mediation profession and implications for the broader conflict management and dispute resolution fields beyond court annexed mediation

    Structural and Functional Studies of Mtr4 and the TRAMP RNA Surveillance Complex

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    Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006-2016).

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    BackgroundEosinophilic lung disease is a poorly understood inflammatory airway disease that results in substantial morbidity.ObjectiveTo describe clinical findings in dogs with eosinophilic lung disease defined on the basis of radiographic, bronchoscopic, and bronchoalveolar lavage fluid (BAL) analysis. Categories included eosinophilic bronchitis (EB), eosinophilic granuloma (EG), and eosinophilic bronchopneumopathy (EBP).AnimalsSeventy-five client owned dogs.MethodsMedical records were retrospectively reviewed for dogs with idiopathic BAL fluid eosinophilia. Information abstracted included duration and nature of clinical signs, bronchoscopic findings, and laboratory data. Thoracic radiographs were evaluated for the pattern of infiltrate, bronchiectasis, and lymphadenomegaly.ResultsThoracic radiographs were normal or demonstrated a bronchial pattern in 31 dogs assigned a diagnosis of EB. Nine dogs had intraluminal mass lesions and were bronchoscopically diagnosed with EG. The remaining 35 dogs were categorized as having EBP based on radiographic changes, yellow green mucus in the airways, mucosal changes, and airway collapse. Age and duration of cough did not differ among groups. Dogs with EB were less likely to have bronchiectasis or peripheral eosinophilia, had lower total nucleated cell count in BAL fluid, and lower percentage of eosinophils in BAL fluid compared to dogs in the other 2 groups. In contrast to previous reports, prolonged survival (>55 months) was documented in dogs with EG.Conclusions and clinical importanceDogs with eosinophilic lung disease can be categorized based on imaging, bronchoscopic and BAL fluid cytologic findings. Further studies are needed to establish response to treatment in these groups
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