American Goat - 1995

Authors include: Susan Kan, Lianne Elizabeth Mercer, Ellen Shepard, Laura Albrecht, Alan Britt, Kathleen A. Carriera, Shelley Getten, Archibald Henderson, Chong Ho Shon, Sophie Hughes, Tracey A. Jennison, Janet Krauss, Jeanne Markell, Rose Rosberg, Rachel Nadel Stark, Brooke Wiese, Rose Maria Woodsonhttps://neiudc.neiu.edu/goat/1005/thumbnail.jp

American Goat - 1994

Authors include: Laura Allyson Hickey, Daiva Karusa, Jeffery McKinnon, George Amabile, James Barnett, Sean Brendan-Brown, Richard Calisch, Michael Carrino, Vic Cavelli, Cait Cerridwen, Robert Cooperman, John Dickson, Robert Klein Engler, David Gardiner, Roger W. Hecht, Zoe Landale, Erroll Miller, Robert A. Nilles, Joan Payne-Kincaid, Michael Paulson, Donna Pucciani, David Rothbarthttps://neiudc.neiu.edu/goat/1004/thumbnail.jp

A Tale of Two Spills: Novel Science and Policy Implications of an Emerging New Oil Spill Model

The 2010 Deepwater Horizon oil release posed the challenges of two types of spill: a familiar spill characterized by buoyant oil, fouling and killing organisms at the sea surface and eventually grounding on and damaging sensitive shoreline habitats, and a novel deepwater spill involving many unknowns. The subsurface retention of oil as finely dispersed droplets and emulsions, wellhead injection of dispersants, and deepwater retention of plumes of natural gas undergoing rapid microbial degradation were unprecedented and demanded the development of a new model for deepwater well blowouts that includes subsurface consequences. Existing governmental programs and policies had not anticipated this new theater of impacts, which thereby challenged decisionmaking on the spill response, on the assessment of natural resource damages, on the preparation for litigation to achieve compensation for public trust losses, and on restoration. Modification of laws and policies designed to protect and restore ocean resources is needed in order to accommodate oil drilling in the deep sea and other frontiers.Keywords: Ecosystem, Petroleum, Deep water horizon, Gulf of Mexico, BlowoutKeywords: Ecosystem, Petroleum, Deep water horizon, Gulf of Mexico, Blowou

A conscious mouse model of gastric ileus using clinically relevant endpoints

BACKGROUND: Gastric ileus is an unsolved clinical problem and current treatment is limited to supportive measures. Models of ileus using anesthetized animals, muscle strips or isolated smooth muscle cells do not adequately reproduce the clinical situation. Thus, previous studies using these techniques have not led to a clear understanding of the pathophysiology of ileus. The feasibility of using food intake and fecal output as simple, clinically relevant endpoints for monitoring ileus in a conscious mouse model was evaluated by assessing the severity and time course of various insults known to cause ileus. METHODS: Delayed food intake and fecal output associated with ileus was monitored after intraperitoneal injection of endotoxin, laparotomy with bowel manipulation, thermal injury or cerulein induced acute pancreatitis. The correlation of decreased food intake after endotoxin injection with gastric ileus was validated by measuring gastric emptying. The effect of endotoxin on general activity level and feeding behavior was also determined. Small bowel transit was measured using a phenol red marker. RESULTS: Each insult resulted in a transient and comparable decrease in food intake and fecal output consistent with the clinical picture of ileus. The endpoints were highly sensitive to small changes in low doses of endotoxin, the extent of bowel manipulation, and cerulein dose. The delay in food intake directly correlated with delayed gastric emptying. Changes in general activity and feeding behavior were insufficient to explain decreased food intake. Intestinal transit remained unchanged at the times measured. CONCLUSION: Food intake and fecal output are sensitive markers of gastric dysfunction in four experimental models of ileus. In the mouse, delayed gastric emptying appears to be the major cause of the anorexic effect associated with ileus. Gastric dysfunction is more important than small bowel dysfunction in this model. Recovery of stomach function appears to be simultaneous to colonic recovery

An X-Ray-Selected Sample of Candidate Black Holes in Dwarf Galaxies

We present a sample of hard X-ray-selected candidate black holes (BHs) in 19 dwarf galaxies. BH candidates are identified by cross-matching a parent sample of ~44,000 local dwarf galaxies (M* = 3 × 10 9 M☉, z < 0.055) with the Chandra Source Catalog and subsequently analyzing the original X-ray data products for matched sources. Of the 19 dwarf galaxies in our sample, eight have X-ray detections reported here for the first time. We find a total of 43 point-like hard X-ray sources with individual luminosities L2-10 keV ~ 10 37 - 10 40 erg s-1. Hard X-ray luminosities in this range can be attained by stellar-mass X-ray binaries (XRBs) and by massive BHs accreting at low Eddington ratio. We place an upper limit of 53% (10/19) on the fraction of galaxies in our sample hosting a detectable hard X-ray source consistent with the optical nucleus, although the galaxy center is poorly defined in many of our objects. We also find that 42% (8/19) of the galaxies in our sample exhibit statistically significant enhanced hard X-ray emission relative to the expected galaxy-wide contribution from low-mass and high-mass XRBs, based on the [data] star formation rate relation defined by more massive and luminous systems. For the majority of these X-ray-enhanced dwarf galaxies, the excess emission is consistent with (but not necessarily due to) a nuclear X-ray source. Follow-up observations are necessary to distinguish between stellar-mass XRBs and active galactic nuclei powered by more massive BHs. In any case, our results support the notion that X-ray-emitting BHs in low-mass dwarf galaxies may have had an appreciable impact on reionization in the early universe

An inclusive Research and Education Community (iREC) model to facilitate undergraduate science education reform

Funding: This work was supported by Howard Hughes Medical Institute grants to DIH is GT12052 and MJG is GT15338.Over the last two decades, there have been numerous initiatives to improve undergraduate student outcomes in STEM. One model for scalable reform is the inclusive Research Education Community (iREC). In an iREC, STEM faculty from colleges and universities across the nation are supported to adopt and sustainably implement course-based research – a form of science pedagogy that enhances student learning and persistence in science. In this study, we used pathway modeling to develop a qualitative description that explicates the HHMI Science Education Alliance (SEA) iREC as a model for facilitating the successful adoption and continued advancement of new curricular content and pedagogy. In particular, outcomes that faculty realize through their participation in the SEA iREC were identified, organized by time, and functionally linked. The resulting pathway model was then revised and refined based on several rounds of feedback from over 100 faculty members in the SEA iREC who participated in the study. Our results show that in an iREC, STEM faculty organized as a long-standing community of practice leverage one another, outside expertise, and data to adopt, implement, and iteratively advance their pedagogy. The opportunity to collaborate in this manner and, additionally, to be recognized for pedagogical contributions sustainably engages STEM faculty in the advancement of their pedagogy. Here, we present a detailed pathway model of SEA that, together with underpinning features of an iREC identified in this study, offers a framework to facilitate transformations in undergraduate science education.Peer reviewe

Models of classroom assessment for course-based research experiences

Course-based research pedagogy involves positioning students as contributors to authentic research projects as part of an engaging educational experience that promotes their learning and persistence in science. To develop a model for assessing and grading students engaged in this type of learning experience, the assessment aims and practices of a community of experienced course-based research instructors were collected and analyzed. This approach defines four aims of course-based research assessment—(1) Assessing Laboratory Work and Scientific Thinking; (2) Evaluating Mastery of Concepts, Quantitative Thinking and Skills; (3) Appraising Forms of Scientific Communication; and (4) Metacognition of Learning—along with a set of practices for each aim. These aims and practices of assessment were then integrated with previously developed models of course-based research instruction to reveal an assessment program in which instructors provide extensive feedback to support productive student engagement in research while grading those aspects of research that are necessary for the student to succeed. Assessment conducted in this way delicately balances the need to facilitate students’ ongoing research with the requirement of a final grade without undercutting the important aims of a CRE education

Shays\u27s Rebellion: Authority and Distress in Post-Revolutionary America

Throughout the late summer and fall of 1786, farmers in central and western Massachusetts organized themselves into armed groups to protest against established authority and aggressive creditors. Calling themselves regulators or the voice of the people, these crowds attempted to pressure the state government to lower taxes and provide relief to debtors by using some of the same methods employed against British authority a decade earlier. From the perspective of men of wealth and station, these farmers threatened the foundations of society: property rights and their protection in courts and legislature. In this concise and compelling account of the uprising that came to be known as Shays’s Rebellion, Sean Condon describes the economic difficulties facing both private citizens and public officials in newly independent Massachusetts. He explains the state government policy that precipitated the farmers’ revolt, details the machinery of tax and debt collection in the 1780s, and provides readers with a vivid example of how the establishment of a republican form of government shifted the boundaries of dissent and organized protest. Underscoring both the fragility and the resilience of government authority in the nascent republic, the uprising and its aftermath had repercussions far beyond western Massachusetts; ultimately, it shaped the framing and ratification of the U.S. Constitution, which in turn ushered in a new, stronger, and property-friendly federal government. A masterful telling of a complicated story, Shays’s Rebellion is aimed at scholars and students of American history.https://scholarworks.merrimack.edu/books/1051/thumbnail.jp