Gaming in Britain 1900-1939: ‘I have got a good following. I have now a Duke and an Earl. In fact I have the cream of Society.’

Gaming, the organisation of Banker’s games for profit, in Britain prior to the Second World War has largely been ignored by academics and historians. There has been an assumption that gaming was conducted at such a small scale that it was either not worthy of research, or, that there was not enough evidence to support specific analysis. This paper will attempt to dispel the above academic myth utilising contemporary press coverage and archive material which will illustrate a vibrant, but illegal gaming industry. In fact, gaming during this period formulated in the minds of the authorities the need for substantial punishments to be utilised against identified operators, this undoubtably led to the introduction of gaming specific defence regulations into Britain during the Second World War. However, it will also establish a continuity of prejudice when dealing with offenders

An evaluation of earth banked tanks for slurry storage

End of project reportThis study examines the feasibility of using earth-banked tanks (EBT’s) as an alternative and economical means of winter storage for animal and other farmyard wastes. The study contains a detailed literature review on the subject, the results of a series of laboratory-scale experiments, field studies and a predictive model of the transport process through the soil liner of an earth-banked tank

Stably free modules over virtually free groups

Let $F_m$ be the free group on $m$ generators and let $G$ be a finite nilpotent group of non square-free order; we show that for each $m\ge 2$ the integral group ring ${\bf Z}[G\times F_m]$ has infinitely many stably free modules of rank 1.Comment: 9 pages. The final publication is available at http://www.springerlink.com doi:10.1007/s00013-012-0432-

The development of feeding and management strategies for milk production systems with very contrasting milk supply patterns.

End of Project ReportsIn Experiment 1, three systems of milk production with contrasting calving patterns, namely 100% autumn (A); 100% spring (S) and 50% autumn: 50% spring (AS), were compared over a two year period. The average milk yield was 6,532, 6,358 and 6,142 kg/cow for systems A, AS and S respectively. The difference in yield was not statistically significant. Fat yield, fat content and protein yield for system S was significantly lower than those with the other two systems. The autumn-calving cows (A) had reduced reproductive performance. Experiment 2 compared grazed grass with grass silage as a forage source for autumn-calving cows in early lactation; it showed that the cows on grazed grass had significantly higher milk protein yield and milk protein content. The cows on the grass silage had significantly lower dry matter intake and a significantly higher bodyweight loss post-calving. The aim of this project was to develop low-cost systems of milk production which lead to an improved milk supply pattern of quality milk for the food industry. In particular, the objective was to research the role which grazed grass can contribute to the feed requirements of cows calving at different times during the year.European Union Structural Funds (EAGGF

Natural Mathematics, the Fibonacci Numbers and Aesthetics in Art

The Mathematics of beauty and beauty in mathematics are important ingredients in learning in the liberal arts. The Fibonacci numbers play an important and useful role in this. This paper seeks to present and illustrate a grounding of visual aesthetics in natural mathematical principles, centered upon the Fibonacci numbers. The specific natural mathematical principles investigated are the Fibonacci numbers, the Fibonacci Spiral, and the Cosmic Bud

Job Mismatches and Labour Market Outcomes: Panel Evidence on Australian University Graduates

The interpretation of graduate mismatch manifested either as overeducation or as overskilling remains problematical. This paper uses annual panel information on both educational and skills mismatches uniquely found in the HILDA survey to analyse the relationship of both mismatches with pay, job satisfaction and job mobility. We find that overeducation and overskilling are distinct phenomena with different labour market outcomes and that their combination results in the most severe negative labour market outcomes. Using panel methodology reduces strongly the size of many relevant coefficients, questioning previous cross-section results and suggesting the presence of considerable unobserved heterogeneity which varies by gender.overeducation, overskilling, wages, satisfaction, mobility

The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c

Caspase activation is a central event in numerous forms of apoptosis and results in the proteolytic degradation of multiple substrate proteins that contribute to the apoptotic phenotype. An important route to caspase activation proceeds via assembly of the “apoptosome” as a result of the cell stress–associated release of mitochondrial cytochrome c. Previous studies have shown that primary neutrophils are largely incapable of mitochondrial respiration, suggesting that these cells either lack functional mitochondria or possess a defective respiratory chain. This prompted us to examine whether neutrophils retain an intact cytochrome c/apoptotic protease-activating factor 1 (Apaf-1) pathway to caspase activation and apoptosis. We show that primary human neutrophils contain barely detectable levels of cytochrome c as well as other mitochondrial proteins. Surprisingly, neutrophil cell–free extracts readily supported Apaf-1–dependent caspase activation, suggesting that these cells may assemble cytochrome c–independent apoptosomes. However, further analysis revealed that the trace amount of cytochrome c present in neutrophils is both necessary and sufficient for Apaf-1–dependent caspase activation in these cells. Thus, neutrophils have a lowered threshold requirement for cytochrome c in the Apaf-1–dependent cell death pathway. These observations suggest that neutrophils retain cytochrome c for the purpose of assembling functional apoptosomes rather than for oxidative phosphorylation

Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic.

BackgroundThe National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for large aneurysms reduces ruptures and AAA-related mortality. AAA screening services have been disrupted following COVID-19 but it is not known how this may impact AAA-related mortality, or where efforts should be focussed as services resume.MethodsWe repurposed a previously validated discrete event simulation model to investigate the impact of COVID-19-related service disruption on key outcomes. This model was used to explore the impact of delayed invitation and reduced attendance in men invited to screening. Additionally, we investigated the impact of temporarily suspending scans, increasing the threshold for elective surgery to 7cm and increasing drop-out in the AAA cohort under surveillance, using data from NAAASP to inform the population.FindingsDelaying invitation to primary screening up to two years had little impact on key outcomes whereas a 10% reduction in attendance could lead to a 2% lifetime increase in AAA-related deaths. In surveillance patients, a 1-year suspension of surveillance or increase in the elective threshold resulted in a 0.4% increase in excess AAA-related deaths (8% in those 5-5.4cm at the start). Longer suspensions or a doubling of drop-out from surveillance would have a pronounced impact on outcomes.InterpretationEfforts should be directed towards encouraging men to attend AAA screening service appointments post-COVID-19. Those with AAAs on surveillance should be prioritised as the screening programme resumes, as changes to these services beyond one year are likely to have a larger impact on surgical burden and AAA-related mortality

Enterobacter Sakazakii: an Emerging Microbe With Implications for Infant Health

Enterobacter sakazakii (E. sakazakii) is an opportunistic pathogen and the aetiological agent in rare but life-threatening cases of meningitis, necrotizing enterocolitis, and sepsis in infants. Among infants, those at greatest risk are neonates (\u3c28 \u3edays), particularly those born prematurely or of low birth weight (g). Consumption of contaminated powdered infant formula (PIF) has been epidemiologically linked with cases of infection. Contamination can occur during the manufacturing process or during postmanufacture reconstitution of formula. Development of rapid, sensitive and specific detection methods will facilitate manufacturers efforts to reduce the occurrence of E. sakazakii in the final powdered product. Furthermore, since PIF is not a sterile product, proper precautions should be taken during handling and reconstitution of formula prior to feeding in order to prevent contamination and proliferation of the bacterium