Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

We tested the hypothesis that supplementation of nicotinamide mononucleotide (NMN), a key NAD (+) intermediate, increases arterial SIRT1 activity and reverses age‐associated arterial dysfunction and oxidative stress. Old control mice (OC) had impaired carotid artery endothelium‐dependent dilation (EDD) (60 ± 5% vs. 84 ± 2%), a measure of endothelial function, and nitric oxide (NO)‐mediated EDD (37 ± 4% vs. 66 ± 6%), compared with young mice (YC). This age‐associated impairment in EDD was restored in OC by the superoxide ([Formula: see text]) scavenger TEMPOL (82 ± 7%). OC also had increased aortic pulse wave velocity (aPWV, 464 ± 31 cm s(−1) vs. 337 ± 3 cm s(−1)) and elastic modulus (EM, 6407 ± 876 kPa vs. 3119 ± 471 kPa), measures of large elastic artery stiffness, compared with YC. OC had greater aortic [Formula: see text] production (2.0 ± 0.1 vs. 1.0 ± 0.1 AU), nitrotyrosine abundance (a marker of oxidative stress), and collagen‐I, and reduced elastin and vascular SIRT1 activity, measured by the acetylation status of the p65 subunit of NFκB, compared with YC. Supplementation with NMN in old mice restored EDD (86 ± 2%) and NO‐mediated EDD (61 ± 5%), reduced aPWV (359 ± 14 cm s(−1)) and EM (3694 ± 315 kPa), normalized [Formula: see text] production (0.9 ± 0.1 AU), decreased nitrotyrosine, reversed collagen‐I, increased elastin, and restored vascular SIRT1 activity. Acute NMN incubation in isolated aortas increased NAD (+) threefold and manganese superoxide dismutase (MnSOD) by 50%. NMN supplementation may represent a novel therapy to restore SIRT1 activity and reverse age‐related arterial dysfunction by decreasing oxidative stress

Event-by-event fluctuations of azimuthal particle anisotropy in Au+Au collisions at sqrt(s_NN) = 200 GeV

This paper presents the first measurement of event-by-event fluctuations of the elliptic flow parameter v_2 in Au+Au collisions at sqrt(s_NN) = 200GeV as a function of collision centrality. The relative non-statistical fluctuations of the v_2 parameter are found to be approximately 40%. The results, including contributions from event-by-event elliptic flow fluctuations and from azimuthal correlations that are unrelated to the reaction plane (non-flow correlations), establish an upper limit on the magnitude of underlying elliptic flow fluctuations. This limit is consistent with predictions based on spatial fluctuations of the participating nucleons in the initial nuclear overlap region. These results provide important constraints on models of the initial state and hydrodynamic evolution of relativistic heavy ion collisions.Comment: 5 pages, 2 figures, Published in Phys. Rev. Lett

Non-flow correlations and elliptic flow fluctuations in gold-gold collisions at sqrt(s_NN)= 200 GeV

This paper presents results on event-by-event elliptic flow fluctuations in Au+Au collisions at sqrt(s_NN)=200Gev, where the contribution from non-flow correlations has been subtracted. An analysis method is introduced to measure non-flow correlations, relying on the assumption that non-flow correlations are most prominent at short ranges (Delta eta < 2). Assuming that non-flow correlations are of the order that is observed in p+p collisions for long range correlations (Delta eta > 2), relative elliptic flow fluctuations of approximately 30-40% are observed. These results are consistent with predictions based on spatial fluctuations of the participating nucleons in the initial nuclear overlap region. It is found that the long range non-flow correlations in Au+Au collisions would have to be more than an order of magnitude stronger compared to the p+p data to lead to the observed azimuthal anisotropy fluctuations with no intrinsic elliptic flow fluctuations.Comment: 9 pages, 7 figures, Published in Phys. Rev.

Charged-Particle Pseudorapidity Distributions in Au+Au Collisions at sqrt(s_NN)=62.4 GeV

The charged-particle pseudorapidity density for Au+Au collisions at sqrt(s_NN)=62.4 GeV has been measured over a wide range of impact parameters and compared to results obtained at other energies. As a function of collision energy, the pseudorapidity distribution grows systematically both in height and width. The mid-rapidity density is found to grow approximately logarithmically between AGS energies and the top RHIC energy. As a function of centrality, there is an approximate factorization of the centrality dependence of the mid-rapidity yields and the overall multiplicity scale. The new results at sqrt(s_NN)=62.4 GeV confirm the previously observed phenomenon of ``extended longitudinal scaling'' in the pseudorapidity distributions when viewed in the rest frame of one of the colliding nuclei. It is also found that the evolution of the shape of the distribution with centrality is energy independent, when viewed in this reference frame. As a function of centrality, the total charged particle multiplicity scales linearly with the number of participant pairs as it was observed at other energies.Comment: 6 pages, 7 figures, submitted to Phys. Rev. C - Rapid Communication

System Size, Energy, Pseudorapidity, and Centrality Dependence of Elliptic Flow

This paper presents measurements of the elliptic flow of charged particles as a function of pseudorapidity and centrality from Cu-Cu collisions at 62.4 and 200 GeV using the PHOBOS detector at the Relativistic Heavy Ion Collider (RHIC). The elliptic flow in Cu-Cu collisions is found to be significant even for the most central events. For comparison with the Au-Au results, it is found that the detailed way in which the collision geometry (eccentricity) is estimated is of critical importance when scaling out system-size effects. A new form of eccentricity, called the participant eccentricity, is introduced which yields a scaled elliptic flow in the Cu-Cu system that has the same relative magnitude and qualitative features as that in the Au-Au system

Validity of the Polar V800 heart rate monitor to measure RR intervals at rest

Purpose To assess the validity of RR intervals and short-term heart rate variability (HRV) data obtained from the Polar V800 heart rate monitor, in comparison to an electrocardiograph (ECG). Method Twenty participants completed an active orthostatic test using the V800 and ECG. An improved method for the identification and correction of RR intervals was employed prior to HRV analysis. Agreement of the data was assessed using intra-class correlation coefficients (ICC), Bland–Altman limits of agreement (LoA), and effect size (ES). Results A small number of errors were detected between ECG and Polar RR signal, with a combined error rate of 0.086 %. The RR intervals from ECG to V800 were significantly different, but with small ES for both supine corrected and standing corrected data (ES 0.999 for both supine and standing corrected intervals. When analysed with the same HRV software no significant differences were observed in any HRV parameters, for either supine or standing; the data displayed small bias and tight LoA, strong ICC (>0.99) and small ES (≤0.029). Conclusions The V800 improves over previous Polar models, with narrower LoA, stronger ICC and smaller ES for both the RR intervals and HRV parameters. The findings support the validity of the Polar V800 and its ability to produce RR interval recordings consistent with an ECG. In addition, HRV parameters derived from these recordings are also highly comparable

System size, energy, centrality and pseudorapidity dependence of charged-particle density in Au+Au and Cu+Cu collisions at RHIC

Charged particle pseudorapidity distributions are presented from the PHOBOS experiment at RHIC, measured in Au+Au and Cu+Cu collisions at sqrt{s_NN}=19.6, 22.4, 62.4, 130 and 200 GeV, as a function of collision centrality. The presentation includes the recently analyzed Cu+Cu data at 22.4 GeV. The measurements were made by the same detector setup over a broad range in pseudorapidity, |eta|<5.4, allowing for a reliable systematic study of particle production as a function of energy, centrality and system size. Comparing Cu+Cu and Au+Au results, we find that the total number of produced charged particles and the overall shape (height and width) of the pseudorapidity distributions are determined by the number of nucleon participants, N_part. Detailed comparisons reveal that the matching of the shape of the Cu+Cu and Au+Au pseudorapidity distributions over the full range of eta is better for the same N_part/2A value than for the same N_part value, where A denotes the mass number. In other words, it is the geometry of the nuclear overlap zone, rather than just the number of nucleon participants that drives the detailed shape of the pseudorapidity distribution and its centrality dependence.Comment: 5 pages, 4 figures. Presented at the 20th International Conference on Nucleus-Nucleus Collisions (Quark Matter 2008), Jaipur, Rajasthan, India, 4-10 February 200

Latest Results from PHOBOS

This manuscript contains a summary of the latest physics results from PHOBOS, as reported at Quark Matter 2006. Highlights include the first measurement from PHOBOS of dynamical elliptic flow fluctuations as well as an explanation of their possible origin, two-particle correlations, identified particle ratios, identified particle spectra and the latest results in global charged particle production.Comment: 9 pages, 7 figures, PHOBOS plenary proceedings for Quark Matter 200

Energy dependence of elliptic flow over a large pseudorapidity range in Au+Au collisions at RHIC

This paper describes the measurement of the energy dependence of elliptic flow for charged particles in Au+Au collisions using the PHOBOS detector at the Relativistic Heavy Ion Collider (RHIC). Data taken at collision energies of $\sqrt{s_{_{NN}}} =$ 19.6, 62.4, 130 and 200 GeV are shown over a wide range in pseudorapidity. These results, when plotted as a function of $\eta'=|\eta|-y_{beam}$, scale with approximate linearity throughout $\eta'$, implying no sharp changes in the dynamics of particle production as a function of pseudorapidity or increasing beam energy.Comment: 5 pages, 4 figure

Transverse Momentum and Rapidity Dependence of HBT Correlations in Au+Au Collisions at sqrt(s_NN) = 62.4 and 200 GeV

Two-particle correlations of identical charged pion pairs from Au+Au collisions at sqrt(s_NN) = 62.4 and 200 GeV were measured by the PHOBOS experiment at RHIC. Data for the 15% most central events were analyzed with Bertsch-Pratt and Yano-Koonin-Podgoretskii parameterizations using pairs with rapidities of 0.4 < y_{\pi\pi} < 1.3 and transverse momenta 0.1 < k_T < 1.4 GeV/c. The Bertsch-Pratt radii R_o and R_l decrease as a function of pair transverse momentum, while R_s is consistent with a weaker dependence. R_o and R_s are independent of collision energy, while R_l shows a slight increase. The source rapidity y_{ykp} scales roughly with the pair rapidity y_{\pi\pi}, indicating strong dynamical correlations.Comment: 5 pages, 4 figures, 2 tables, submitted to Phys. Rev.