Rat Model of Staphylococcal Enterotoxin B-Induced Rhinosinusitis

ObjectivesIt has been proposed that microbial persistence, superantigen (SA) production, and host T-cell response may be involved in the development of chronic rhinosinusitis. According to the SA hypothesis, a single intranasal application of SA such as staphylococcal enterotoxin B (SEB) may induce chronic eosinophilic rhinosinusitis. This study aimed to develop a rat model of rhinosinusitis induced by intranasally applied SEB.MethodsForty µL of SEB (100 µg/mL) or phosphate buffered saline was applied intranasally through each naris in 4 week-old Sprague-Dawley test rats (N=36) and controls (N=16), respectively. Following sacrifice at 1, 5, 14, and 28 days, the obtained nasal cavity and sinuses were prepared for histologic investigation. The histologic sections were examined in a blind manner for the ratio of the sinus spaces occupied by inflammatory cell clusters and the number of inflammatory cells in the lamina propria.ResultsInfiltration of neutrophils in the lamina propria and appearance of neutrophil clusters in the sinus spaces were observed in the SEB-applied rats. The ratio of the sinus spaces occupied by neutrophil clusters and the number of neutrophils infiltrated in the lamina propria increased significantly at day 1 as compared with the control rats.ConclusionIntranasally applied SEB induces acute neutrophilic rhinosinusitis in rats. Eosinophilic inflammation was not demonstrated. The mere presence of SA in the nose does not necessarily induce SA-induced inflammation, as suggested by the SA hypothesis

Effect of total intravenous versus inhalation anesthesia on long-term oncological outcomes in patients undergoing curative resection for early-stage non-small cell lung cancer: a retrospective cohort study

Background Propofol-based total intravenous anesthesia (TIVA) improves long-term outcomes after cancer surgery compared with inhalation anesthesia. However, its effect on patients undergoing non-small cell lung cancer (NSCLC) surgery remains unclear. We aimed to compare the oncological outcomes of TIVA and inhalation anesthesia after curative resection of early-stage NSCLC. Methods We analyzed the medical records of patients diagnosed with stage I or II NSCLC who underwent curative resection at a tertiary university hospital between January 2010 and December 2017. The primary outcomes were recurrence-free survival (RFS) and overall survival (OS) according to anesthesia type. Results We included 1,508 patients with stage I/II NSCLC. The patients were divided into the TIVA (n = 980) and Inhalation (n = 528) groups. The two groups were well-balanced in terms of baseline clinical characteristics. The TIVA group demonstrated significantly improved RFS (7.7 years, 95% CI [7.37, 8.02]) compared with the Inhalation group (6.8 years, 95% CI [6.30, 7.22], P = 0.003). Similarly, TIVA was superior to inhalation agents with respect to OS (median OS; 8.4 years, 95% CI [8.08, 8.69] vs. 7.3 years, 95% CI [6.81, 7.71]; P < 0.001). Multivariable Cox regression analysis revealed that TIVA was an independent prognostic factor related to recurrence (hazard ratio [HR]: 1.24, 95% CI [1.04, 1.47], P = 0.014) and OS (HR: 1.39, 95% CI [1.12, 1.72], P = 0.002). Conclusions Propofol-based TIVA was associated with better RFS and OS than inhalation anesthesia in patients with stage I/II NSCLC who underwent curative resection

Analysis of Developmental Chronology of South Korean Compressed Growth as a Reference from Sustainable Development Perspectives

Global challenges including overpopulation, climate change, and income inequality have increased, and a demand for sustainability has emerged. Decision-making for sustainable development is multifaceted and interlinked, owing to the diverse interests of different stakeholders and political conflicts. Analysing a situation from all social, political, environmental, and economic perspectives is necessary to achieve balanced growth and facilitate sustainable development. South Korea was among the poorest countries following the Korean War; however, it has developed rapidly since 1955. This growth was not limited to economic development alone, and the chronology of South Korean development may serve as a reference for development in other countries. Here, we explore the compressed growth of South Korea using a narrative approach and time-series, comparative, and spatial analyses. Developmental indicators, along with the modern history of South Korea, are introduced to explain the reasons for compressed growth. The development of the mid-latitude region comprising 46 countries in this study, where nearly half of Earth’s population resides, was compared with that of South Korea; results show that the developmental chronology of South Korea can serve as a reference for national development in this region

Internal Market for Executives: Inter-divisional Resource Sharing and Executive Transfer

The problem of resource allocation is a particularly pressing issue in large and highly diversified companies, where business divisions of different industry dynamics compete for limited resources. However, prior work has focused primarily on impersonal, often structural, mechanisms for resource coordination and control, paying scant attention to the actual process involving human agents such as executives who perform the role of coordination and control in strategic resource allocation decisions. To address this situation, we explore how the inter-divisional mobility of executives serves as a key mechanism to manage the corporate-wide sharing of both tangible and intangible resources. Using business groups in Korea from 1989 to 2006 as an empirical setting, we demonstrate that patterns of executive transfer among divisions clearly coincide with group-level resources and intra-group dependence relationship. Our results also show that such patterns are reshaped by the influence of external environments, i.e., product market competition and capital market control. This study highlights the unique importance of executives who carry the role of coordination and control in sharing resources within a firm, and thereby provides new insight for extant research that has viewed internal labor markets as sources of individual or firm-specific skills

Interunit Executive Redeployment in Multiunit Firms: Evidence from Korean Business Groups

Building on the literature on resource reconfiguration theory, we formulate a new theoretical framework that explains how executive redeployment within a diversified firm transfers different types of human capital embodied in executives to different units facing specific business challenges. In the empirical context of Korean business groups, we find that executives with unit-specific human capital, like turnaround experience, competitive experience, and international expansion experience, are redeployed to units with corresponding business challenges like financial difficulties, intensifying competition, and early-stage international expansion, respectively. We also show that executives with unit generic human capital, like corporate management practices and interunit coordination experiences, are redeployed to younger units seeking to establish corporate-level policies and practices. Additional analyses also show that the value of firm-specific human capital in driving the redeployment of executives is contingent on their functional orientation and seniority