1 research outputs found
On-Demand Modulation of Bacterial Cell Fates on Multifunctional Dynamic Substrates
This
paper reports unprecedented dynamic surfaces based on zwitterionic
low-density self-assembled monolayers (LDSAMs) of alkanethiolates
on gold, which integrate three interconvertible statesbacteria-adherable,
bactericidal, and nonfouling statesthrough electrical modulations.
The conformations of alkanethiolates were electrically modulated to
generate zwitterionic, anionic, and cationic surfaces, which responded
differently to bacteria and determined the fate of bacteria. Furthermore,
the reversible switching of multifunctions of the surface was realized
for killing bacteria and subsequently releasing dead bacteria from
the surface. For practical application of our strategy, we examined
the selective antibacterial effect of our surface for eradication
of mycoplasma contaminants in contaminated mammalian cell cultures