Determining the Critical Success Factors in ERP Systems Implementations with Fuzzy Cognitive Mapping: The Case of Turkey

Abstract: The purpose of this study is to determine the factors affecting ERP implementation success by using fuzzy cognitive mapping method. Fuzzy Cognitive Mapping (FCM) is used to determine critical success factors affecting ERP implementation. FCM is based on graph theory, which was formulized by mathematician Euler in 1736. Fuzz cognitive method is very useful method for exploring the subjective factors of subject and the relationships between them. In this study we draw 16 fuzzy cognitive maps with interviewers whose are the owner or manager of enterprises or ERP team managers of the ERP teams. By the constructive analysis of the individual cognitive maps, "giving ERP education to team or end users", "Conformity and reliability of data" and "Support of top level management" variables are the most central variables. By the neural network analysis we find that if the ERP education increases, raises; "meeting the business needs of ERP system", "the efficiency of project plan", "project management and time schedule" variables increases too. And according to the second scenario if top level managers support the use of ERP system increases, raises; "meeting the business needs of ERP system", "giving ERP education to team and last users", "self-sacrifice of project team", "existence responsible persons from each department in the project team" variables are increases too. Also, this paper represents a first attempt for using fuzzy cognitive mapping to determine the factors, which affect the success of ERP application

Toll Like Receptor (TLR) signaling pathways

The immune system provides an immediate defence mechanism in cases such as pathogen invasion or damage. It is also responsible for initiating an antigen-specific response of the adaptive immune system. Toll like receptors (TLRs) are one of the important elements of the immune system and have a critical role in the detection of microbial infection. TLRs have the specificity to detect infection and activate the immune system. TLRs rapidly recognize microbial products containing relevant exogenous and endogenous ligands. As a result, it modulates the expression of various genes in the cell and induces an antigen-specific adaptive immune response. TLRs can be expressed in both body cells and immune system related cells. Studies on the role of Toll like receptors in the pathogenesis of various diseases and the potential of biomarkers in effective treatment research are increasing day by day and attract the attention of scientists. © 2023 Nova Science Publishers, Inc. All rights reserved

Changes in structure during the corpus luteum's formation

Purpose: Our study aims to investigate whether new follicles form among fibroblast-like cells in the region after the restructuring of the surface epithelium and tunica albuginea adjacent to the corpus luteum. Additionally, another goal is to demonstrate the structures developed from the follicles and the histological changes in the ovary. Materials and methods: Histological sections of the corpus luteum, formed from the Graafian follicle after ovulation, were prepared from ovarian tissues of 12-14 months old Wistar albino rats. Results: When the corpus luteum reaches a high volume, the number of fibroblast-like cells in the tunica albuginea is quite low. Subsequently, it has been observed that the number of fibroblast-like cells in the tunica albuginea rapidly increases, and these cells form concentric arrangements of collagen fibers. Additionally, the formation of primordial and primary follicles between the surface epithelium and the tunica albuginea adjacent to the corpus luteum has been observed. Conclusion: Examining the ovary as a whole and investigating the developmental processes of structures can assist in gaining a better understanding of the dynamics of this organ. © 2024, Pamukkale University. All rights reserved

Effect of alpha lipoic acid on epithelial mesenchymal transition in SKOV-3 cells

Background: Ovarian cancer is the fifth leading cause of cancer-related death in women. Patients are usually diagnosed with advanced tumor metastass. Epithelial over cancer cells spread from primary tumor by undergoing epithelial mesenchymal transition (EMT). It has been suggested that alpha lipoic acid (ALA), a natural antioxidant lipophilic compound, reduces the oxidative stress by causing apoptosis and inhibition of proliferation of cell in cancer cells. The aim of our study was to establish a transforming growth factor β1 (TGF β1) dependent epithelial mesenchymal transition model in the SKOV-3 ovarian adenocarcinoma cell line which is an epithelial subtype of ovarian cancer and to investigate the effects of alpha lipoic acid on EMT and ovarian cancer migration. Methods: For establish an EMT model, SKOV-3 cells were treated with different dose of TGF β1 and XTT cell viability kit was used to find IC 50 dose of ALA. Four different groups that are control, TGF β1, ALA and ALA + TGF β1 were created. Changes in the expression of genes related to EMT markers that are E-cadherin, vimentin, Snail, Slug, Twist and Zeb were analyzed with quantitative real-time PCR. These proteins were determined with the immunocytochemistry method. The migration capacity was analyzed with wound healing assay. Matrigel invasion capacity test was used to show invasion and colonization test to show colonization. Results: The dose of TGF β1 was determined 100 ng/ml at 72 h, the IC50 dose of ALA 219.033 µM at 48 h was determined. EMT markers in the TGF β1 group were compatible with EMT and it was shown to inhibit EMT in the groups given ALA. According to wound healing, colonization and invasion experiments, proliferation and invasion increased in TGF β1 group, but decreased in ALA and combined groups (p 0.05). Conclusion: These results indicate that ALA suppresses the metastasis of ovarian cancer cells by regulating EMT, implying that ALA might be a potential therapeutic agent for the treatment of ovarian cancer. © 2023 Elsevier B.V.Pamukkale Üniversitesi, PAÜ: 2021TIPF006Notably, the Faculty of Pamukkale University Scientific Research Project Coordination Unit (grant 2021TIPF006) would be greatly acknowledged for their support

The cytotoxic and genotoxic effects of daidzein on MIA PaCa-2 human pancreatic carcinoma cells and HT-29 human colon cancer cells

Daidzein (DZ) has anti-inflammatory and antioxidant effects, as well as the dose-dependent inhibition effect on cancer cells. In this study, the cytotoxic and genotoxic effects of DZ on HT-29 (human colorectal adenocarcinoma cells) and MIA PaCa-2 (human pancreatic cancer cells) cell lines were determined using the XTT method and Comet assay, respectively. IC50 concentrations of DZ were found to be 200 µM in both MIA PaCa-2 and HT-29 cells treated with DZ for 48 hours (h). When the cells were treated with 200 µM of DZ for 48 h, DNA damage was observed in both cell lines. DNA tail length (TL), tail moment (TM), and tail intensity (TI) increased more in MIA PaCa-2 cells treated with 200 µM of DZ than those in the control cell (untreated MIA PaCa-2 cell) group (p ;lt; 0.01). However, only DNA-TI and DNA-TM exhibited higher increases in HT-29 cells treated with 200 µM of DZ than those in the control cell (untreated HT-29 cell) group (p ;lt; 0.01). This shows that DZ has cytotoxic and genotoxic effects on both cell lines. The observed genotoxic effects of DZ still need to be confirmed in additional future studies. © 2018, © 2018 Informa UK Limited, trading as Taylor ; Francis Group