Relationship Between Atopy Patch Test with Foods and SCORAD

Background and Design: The relationship between food and atopic dermatitis (AD) is controversial. Atopy patch test (APT) gained prominence due to low specificity of “fresh prick tests” (FPT) with foods, commonly late occurrence of lesions in AD and, thus, the inconsistencies in anamneses, and being the provocative tests time consuming and risky, as well as due to the role of T lymphocytes in the pathophysiology of the disease. In this study, we investigated the relationship of APT and FPT made with food with SCORAD index assessing the disease severity.Materials and Methods: Forty-five children (21 males and 24 females) aged between 2-15 years who were diagnosed with AD in our outpatient clinic between May 2006 and May 2007 were included in the study. FPT and APT with eggs, milk and wheat flour were performed in all patients. The severity of illness was assessed using the SCORAD index. Statistical analysis was performed using SPSS version 11.0 for Windows. A p value of less than 0.05 was considered statistically significant

Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age

Objective: The effect of ghrelin on growth of the newborn has long been argued, but not fully clarified. In this study, we aimed to investigate the relationship between ghrelin levels and growth parameters in the first 3 months of life

Evaluation of the rate of thrombocytosis in lower respiratory tract and upper urinary system ınfections

Alt solunum yolu enfeksiyonları ve üst üriner sistem enfeksiyonlarında trombositoz oranlarının çıkarılması ve degerlendirilmesi amaçlanmıstır. Bu çalısmada “GATAHaydarpasa Egitim Hastanesi Çocuk Klinigi'nde” 1 Ocak 2006- 1 Ocak 2009 yılları arasında yatırılarak tedavi verilen 20 alt solunum yolu enfeksiyonu (ASYE) ve 22 üst üriner sistem enfeksiyonu (ÜÜSE) tanısı alan hastanın dosyaları retrospektif olarak incelendi. Reaktif trombositoz, genel olarak kabul gören trombosit sayısının 500.000/mm üzeri olması kabul edildi. Istatistiksel veriler SPSS 13.0 ile degerlendirildi. Çalısmamızda trombositoz tanı anında üst üriner sistem enfeksiyonlarında daha fazla bulundu (ASYE %25, ÜÜSE %36). Üst üriner sistem enfeksiyonlarında en sık üreyen mikroorganizma Escherichia coli (n:12 %54) olarak tespit edildi. Çalısmamızda, alt solunum yolu enfeksiyonu ve üst üriner sistem enfeksiyonunda tanı anında görülen reaktif trombositoz ile hastalık siddeti karsılastırılmıs, arasında istatistiksel olarak anlamlı bir iliski bulunamamıstır.To evaluate the rates of thrombocytosis in lower respiratory tract (LRTI) and upper urinary system infections (UUSI). In this study, rates of thrombocytosis were evaluated in patients hospitalized and treated with the diagnosis of LRTI (n=20) or UUSI (n=22) in “GATA Haydarpasa Teaching Hospital, Department of Pediatrics” between 2006-2009, retrospectively. Reactive thrombocytosis is defined as the platelet count over 500.000/mm . Statistical analysis was performed by SPSS forWindows version 13.0. p'0.05 was accepted as statistically significant. Thrombocytosis was found to be higher in the UUSI (%36) at the time of the diagnosis compared to the LRTI group (25%). The most common microorganism identified in the UUSI was Escherichia coli (n=12, 54%). There was no significant relationship between the reactive thrombocytosis observed at the time of the diagnosis and the severity of the disease in theLRTI and the UUSI

A Simple Procedure may Cause Severe Results

Capillary blood sampling via a heel puncture is a common procedure performed on hospitalized neonates. If not performed properly, a heelstick can lead to complications. The clinical and financial impact of complications can be significant. Also in some situations, the procedure could be complicated with skin infections, hematomes, soft tissue infections, arthritis and osteomyelitis. We report an infant complicated with arthitis and soft tissue infection secondary to heel puncture and we want to emphesize the importance of neonatal procedures

Hyperbaric Oxygen Therapy In Calcium Chloride Extravasation Injuries: An Experimental Animal Study

Aim: Parenteral alimentation fluids containing calcium are widely used to treat sick neonates and children. Extravasation of calcium presents with local swelling, erythema, blistering and progresses to skin necrosis and skin loss. Several treatment modalities including hyperbaric oxygen therapy have been used for extravasation injuries. The role of hyperbaric oxygen therapy on extravasation injuries was investigated in this study by an experimental rat model based on facilitating effect of hyperbaric oxygen on wound healing. Methods: After shaving the dorsal side of 16 female Wistar rats, 1 ml of calcium chloride were injected intradermally. The rats were divided into two groups as control and hyperbaric oxygen. The control group received no treatment while the hyperbaric oxygen group received hyperbaric oxygen therapy for 7 days after injection. At the end of seventh day skin biopsy including all necrotic tissue and surrounding healthy tissue were obtained and histopathologic examination was performed for control and hyperbaric oxygen groups. Results: Hyperbaric oxygen group showed a statistically significant preservation of epidermis and dermis with minimal necrosing findings of skin injury. Conclusion: Although further research is required to develop management guidelines, we concluded that in this experimental study, hyperbaric oxygen therapy prevents dermal injury and may decrease the morbidity associated with calcium chloride extravasation injury

Basit Bir Prosedür Ciddi Sonuçlara Yol Açabilir

Capillary blood sampling via a heel puncture is a common procedure performed on hospitalized neonates. If not performed properly, a heelstick can lead to complications. The clinical and financial impact of complications can be significant. Also in some situations, the procedure could be complicated with skin infections, hematomes, soft tissue infections, arthritis and osteomyelitis. We report an infant complicated with arthitis and soft tissue infection secondary to heel puncture and we want to emphesize the importance of neonatal procedures.Hastaneye yatan yenidoğanlarda topuk delerek alınan kapiller kan örneği genel bir prosedürdür. Eğer düzgün olarak yapılmazsa, komplikasyonlara yol açabilir. Komplikasyonların klinik ve finansal etkileri önemli olabilir. Ayrıca bazı koşullarda işlem deri enfeksiyonları, hematomlar, yumuşak doku enfeksiyonları, artrit ve osteomyelit ile komplike hale gelebilir. Biz,topuk kanı alımına ikincil artrit ve yumuşak doku enfeksiyonu ile komplike hale gelen bir infantı rapor ederek yenidoğanlardaki işlemlerin önemini vurgulamak istiyoruz

Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3

WOS: 000379187900010PubMed ID: 26943480Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental retardation, hyperactivity, cerebral palsy, epilepsy and neuroendocrine disturbances. Herein, we examined acute and subacute correlations between neuronal degeneration and serum growth factor changes, including growth hormone (GH), insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) after hypoxic-ischemia (HI) in neonatal rats. In the acute phase of hypoxia, brain volume was increased significantly as compared with control animals, which was associated with reduced GH and IGF-1 secretions. Reduced neuronal survival and increased DNA fragmentation were also noticed in these animals. However, in the subacute phase of hypoxia, neuronal survival and brain volume were significantly decreased, accompanied by increased apoptotic cell death in the hippocampus and cortex. Serum GH, IGF-1, and IGFBP-3 levels were significantly reduced in the subacute phase of HI. Significant retardation in the brain and body development were noted in the subacute phase of hypoxia. Here, we provide evidence that serum levels of growth-hormone and factors were decreased in the acute and subacute phase of hypoxia, which was associated with increased DNA fragmentation and decreased neuronal survival.EMBO (European Molecular Biology Organization); Turkish Academy of Sciences (TUBA)This work was supported by EMBO (European Molecular Biology Organization) installation Grant and The Turkish Academy of Sciences (TUBA)