Maturation of pro-hormone convertases PC2 and PC3 and their interaction with the neuroendocrine protein 7B2

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Delivery of multidisciplinary care in the field of differences and disorders of sex development (DSD)

Introduction: Differences and disorders of sex development (DSD) are a diverse group of conditions, which often present in early childhood and may require input from a group of experts in a wide range of clinical fields. Clinical guidance in this field recommends that these experts function as a multidisciplinary team (MDT) within which each expert has a defined role which will ensure an integrated and streamlined approach to the care of affected individuals. Areas covered: This review will focus on the benefits of multidisciplinary care for people with DSD, as well as the challenges which may be faced. Expert opinion: Core members of the MDT for people with DSD include endocrinologists, surgeons, psychologists, geneticists, specialist nurses, radiologists and gynaecologists, although many other healthcare professionals may also be pertinent, at different stages of the patient’s life. With greater acceptance of remote and digital health care technology, there is a need to review the traditional concepts of the clinical MDT so that new care models can be explored for effective and efficient delivery of complex care

The propeptide of prohormone convertase PC2 acts as a transferable aggregation and membrane-association signal

5 graph.International audienc

The propeptide of prohormone convertase PC2 acts as a transferable aggregation and membrane-association signal

5 graph.International audienc

Sorting of PC2 to the regulated secretory pathway in AtT20 cells

4 graph.International audienc

Sorting of PC2 to the regulated secretory pathway in AtT20 cells

4 graph.International audienc