Formation of study cohort and criteria for exclusion.

<p>Abbreviations: eGFR, estimated glomerular filtration rate; S_Cr, serum creatinine; TST90, total sleep time spent with oxygen saturation <90%.</p

Association between nocturnal hypoxia and risk of accelerated loss of kidney function^*.

<p>Abbreviations: OR, odds ratio; CI, confidence interval.</p><p>*Reference group is subjects without nocturnal hypoxia.</p>†<p>Adjusted for age, body mass index, diabetes and heart failure.</p>‡<p>Adjusted for respiratory disturbance index (RDI), age, body mass index, diabetes and heart failure.</p

Baseline subject characteristics, overall and by presence of nocturnal hypoxia^*.

<p>Abbreviations: eGFR, estimated glomerular filtration rate; RDI, respiratory disturbance index; BMI, body mass index; COPD, chronic obstructive pulmonary disease; ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker.</p><p>Cardiovascular Medications include acetylsalicylic acid, nitrates, calcium channel blockers, beta blockers, arrhythmia medications, and lipid lower medications.</p><p>*Results presented as mean (standard deviation) unless otherwise indicated.</p>†<p>p-value for categorical variables based on a chi-square test of independence; p-value for continuous variables based on a 2-sample t-test for a difference, assuming equal variances.</p>‡<p>Neck Circumference: n = 683 (Overall), n = 381 (Nocturnal Hypoxia absent), n = 302 (Nocturnal Hypoxia present).</p