Nursing in a War Zone

The al Asad Airbase in western Iraq is big. Really big. So big, in fact, that a decade ago it housed more than 17,000 U.S. servicemen and women and civilian contractors. It had a movie theater, two swimming pools and a Pizza Hut

The Hellie Years: A Look at the Legacy of Linfield\u27s 19th President

Richard Ekman was only eight years out of graduate school, a tenured history professor and dean at Hiram College, when the curriculum vitae for Thomas L. Hellie came across his desk in 1980. Ekman, who admits to being “very young” as an administrator in those days, followed a hunch and made a decision he still calls one of his best. Hellie, who hadn’t yet finished his Ph.D. dissertation at University of Missouri, became Hiram’s new assistant professor of theatre

The Liberal Arts under Attack

Economic and demographic shifts are creating a new reality for colleges and universities. Nowhere, perhaps, is that being felt more strongly than at private liberal arts colleges

Classroom 4.0

Artificial intelligence, once the stuff of futuristic books and films, is finding its way onto college campuses. How is American higher education adapting to the digital age

Derailing individualized ovarian stimulation

No abstract available

Functional Evaluation of Bacteriophage T4 Rad50 Signature Motif Residues

The repair of DNA double-strand breaks (DSBs) is essential to maintaining the integrity of the genome, and organisms have evolved a conserved mechanism to facilitate their repair. In eukaryotes, archaea, and some bacteriophage, a complex made up of Mre11 and Rad50 (MR complex), which are a nuclease and ATPase, respectively, is involved in the initial processing of DSBs. Rad50 is a member of the ATP Binding Cassette (ABC) protein superfamily, the members of which contain an important Signature motif that acts in trans to complete the dimeric ATP binding site. To explore the functional relevance of this motif, four of its five residues were mutated in bacteriophage T4 Rad50, and their respective ATPase and nuclease activities were evaluated. The mutations reveal the functional roles of the Signature motif in ATP binding, hydrolysis, and cooperativity. In several mutants, the degree of DNA activation of ATP hydrolysis activity is reduced, indicating that the Signature motif is involved in allosteric signal transmission between the DNA and ATP binding sites of the MR complex. ATP hydrolysis is not required for nuclease activity when the probe is near the beginning of the DNA substrate; however, when an internal probe is used, decreases in ATPase activity have substantial effects on nuclease activity, suggesting that ATP hydrolysis is involved in translocation of the complex. Unexpectedly, the ATP hydrolysis and nuclease activities are not directly correlated with each other, and each mutation appears to differentially affect the exonuclease activity of Mre11

The 2-generalized knot group determines the knot

Generalized knot groups $G_n(K)$ were introduced independently by Kelly (1991) and Wada (1992). We prove that $G_2(K)$ determines the unoriented knot type and sketch a proof of the same for $G_n(K)$ for $n>2$.Comment: 4 page

Attention to attributes and objects in working memory

It has been debated on the basis of change-detection procedures whether visual working memory is limited by the number of objects, task-relevant attributes within those objects, or bindings between attributes. This debate, however, has been hampered by several limitations, including the use of conditions that vary between studies and the absence of appropriate mathematical models to estimate the number of items in working memory in different stimulus conditions. We re-examined working memory limits in two experiments with a wide array of conditions involving color and shape attributes, relying on a set of new models to fit various stimulus situations. In Experiment 2, a new procedure allowed identical retrieval conditions across different conditions of attention at encoding. The results show that multiple attributes compete for attention, but that retaining the binding between attributes is accomplished only by retaining the attributes themselves. We propose a theoretical account in which a fixed object capacity limit contains within it the possibility of the incomplete retention of object attributes, depending on the direction of attention

Drug diffusion from polymeric delivery devices: a problem with two moving boundaries

An existing model for solvent penetration and drug release from a spherically-shaped polymeric drug delivery device is revisited. The model has two moving boundaries, one that describes the interface between the glassy and rubbery states of polymer, and another that defines the interface between the polymer ball and the pool of solvent. The model is extended so that the nonlinear diffusion coefficient of drug explicitly depends on the concentration of solvent, and the resulting equations are solved numerically using a front-fixing transformation together with a finite difference spatial discretisation and the method of lines. We present evidence that our scheme is much more accurate than a previous scheme. Asymptotic results in the small-time limit are presented, which show how the use of a kinetic law as a boundary condition on the innermost moving boundary dictates qualitative behaviour, the scalings being very different to the similar moving boundary problem that arises from modelling the melting of an ice ball. The implication is that the model considered here exhibits what is referred to as ``non-Fickian'' or Case II diffusion which, together with the initially constant rate of drug release, has certain appeal from a pharmaceutical perspective