An Atheistic Argument from Ugliness

The theistic argument from beauty has what we call an 'evil twin', the argument from ugliness. The argument yields either what we call 'atheist win', or, when faced with aesthetic theodicies, 'agnostic tie' with the argument from beauty

The Environment for Application Software Integration and Execution (EASIE), version 1.0. Volume 2: Program integration guide

The Environment for Application Software Integration and Execution, EASIE, provides a methodology and a set of software utility programs to ease the task of coordinating engineering design and analysis codes. EASIE was designed to meet the needs of conceptual design engineers that face the task of integrating many stand-alone engineering analysis programs. Using EASIE, programs are integrated through a relational data base management system. In volume 2, the use of a SYSTEM LIBRARY PROCESSOR is used to construct a DATA DICTIONARY describing all relations defined in the data base, and a TEMPLATE LIBRARY. A TEMPLATE is a description of all subsets of relations (including conditional selection criteria and sorting specifications) to be accessed as input or output for a given application. Together, these form the SYSTEM LIBRARY which is used to automatically produce the data base schema, FORTRAN subroutines to retrieve/store data from/to the data base, and instructions to a generic REVIEWER program providing review/modification of data for a given template. Automation of these functions eliminates much of the tedious, error prone work required by the usual approach to data base integration

Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females11Sources of support: National Health and Medical Research Council of Australia, Masonic Centenary Medical Research Foundation.

AbstractObjective: To describe the association between early radiographic osteoarthritis of the knee (ROA), knee cartilage volume and tibial bone surface area.Methods: Cross-sectional convenience sample of 372 male and female subjects (mean age 45 years, range 26–61). Articular cartilage volume, bone area and volume were determined at the patella, medial tibial and lateral tibial compartments by processing images acquired in the sagittal plane using T1-weighted fat saturation MRI. ROA was assessed with a standing semiflexed radiograph and the OARSI atlas for joint space narrowing and osteophytosis. Both radiographs and MRIs were performed in the right knee and read by different observers.Results: ROA (predominantly grade 1) was present in 17% of subjects of which medial joint space narrowing was most common (14%) followed by medial osteophytes (6%). Grade one medial joint space narrowing was associated with substantial reductions in cartilage volume at both the medial and lateral tibial and patellar sites within the knee (adjusted mean difference 11–13%, all P<0.001) while grade one osteophytosis was associated with substantial increases in both lateral and medial tibial joint surface area (adjusted mean difference 10–16%, all P<0.001). In contrast, osteophytosis was not associated with a significant change in cartilage volume and joint space narrowing was not associated with a significant change in tibial bone area (all P>0.05).Conclusions: Early medial compartment ROA is associated with substantial reductions in cartilage volume and increases in bone area. These large changes, when combined with similar measurement error for MRI and radiographs, suggest that MRI may be superior at detecting and hence understanding early osteoarthritis of the knee in humans

The classification of subfactors of index at most 5

A subfactor is an inclusion of von Neumann algebras with trivial centers. The simplest example comes from the fixed points of a group action , and subfactors can be thought of as fixed points of more general group-like algebraic structures. These algebraic structures are closely related to tensor categories and have played important roles in knot theory, quantum groups, statistical mechanics, and topological quantum field theory. There is a measure of size of a subfactor, called the index. Remarkably, the values of the index below 4 are quantized, which suggests that it may be possible to classify subfactors of small index. Subfactors of index at most 4 were classified in the 1980s and early 1990s. The possible index values above 4 are not quantized, but once you exclude a certain family, it turns out that again the possibilities are quantized. Recently, the classification of subfactors has been extended up to index 5, and (outside of the infinite families) there are only 10 subfactors of index between 4 and 5. We give a summary of the key ideas in this classification and discuss what is known about these special small subfactors.The first author was supported by the NSF under Grant No. DMS-0301173 The second author was supported by the Australian Research Council under the Discovery Early Career Researcher Award DE120100232, and Discovery Project DP140100732 The third author was supported by a NSF Postdoctoral Fellowship at Columbia University. All authors were supported by DARPA grants HR0011-11-1-0001 and HR0011-12-1-0009

Promoting mobility and healthy aging in men: a narrative review

Maintaining mobility is an important aspect of health and well-being in older men. This literature review describes several modifiable and nonmodifiable risk factors impacting bone, muscle, and joint health. Exercise and nutritional interventions may help to prevent the progressive deterioration in bones, muscles, and joints impacting mobility in later life. Limitations in mobility are increasingly recognized as a major public health problem due to an aging population and growing number of older individuals affected by disabling comorbidities. Despite increasing numbers and debilitating consequences, there are no guidelines providing recommendations on strategies to maintain mobility for healthy aging among older men. This narrative review aims to fill this literature gap. PubMed, Scopus, and Google Scholar databases were searched using predefined search terms. Primary studies, exploratory analyses, cross-sectional surveys, meta-analyses, evidence-based clinical reviews, and guidelines from nationally recognized societies focusing on mobility in older men and key elements including bone, muscle and joint health, and balance were selected. Several modifiable and nonmodifiable risk factors have been reported in the literature that impact bone, muscle, and joint health and predispose older men to falls and fractures. The most common conditions impacting bones, muscles, and joints are osteoporosis, sarcopenia, and osteoarthritis, respectively. In addition to being key contributors to disability in the elderly, these conditions are all associated with a higher mortality risk. Although more studies are required, current evidence supports the use of various nonpharmacological (mainly exercise and nutrition) and/or pharmacological treatment modalities to help prevent and/or reverse these conditions. Incorporating lifestyle interventions involving exercise and nutrition at a younger age can help prevent the age-related, progressive deterioration in bones, muscles, and joints that can reduce mobility in later life. Established barriers to physical activities (e.g., poor health, social isolation) in men are important to consider for optimizing outcomes

Exploring the nuclear pion dispersion relation through the anomalous coupling of photon to photon and neutral pion

We investigate the possibility of measuring the pion dispersion relation in nuclear matter through the anomalous coupling in the reaction \gamma - \gamma' \pi_0. It is shown that this reaction permits the study of pionic modes for space-like momenta. If the pion is softened in nuclear matter due to mixing with the delta-hole state, significant strength for this reaction is expected to move into the space-like region. Competing background processes are evaluated, and it is concluded that useful insight can be obtained experimentally, but only through a difficult exclusive measurement