5,589 research outputs found

    The Evolution of Emergency Management Networks: The Brazos County, TX Evacuation Network from 2000-2009

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    Emergency management is a field in which collaborative activities are inescapable. Emergency planning and response increasingly involves a diverse array of actors across field (emergency management, public health, law enforcement, etc.), sector (government, nonprofit, and for-profit), and level of government (local, state, and federal). The necessity of collaboration is built into the logic of escalation in the Stafford Act and the nature of emergency events as boundary spanning threats. While the necessity of collaboration is clear, the dynamics of this collaboration are less well understood. This paper assesses the temporal dynamics of an emergency management network in a moderately sized community in central Texas. The evolution of the network between 2000 and 2009 make clear that actors are both quick to join and to leave the network while the network maintains its centralized character throughout the time period

    Resilience of Post-disaster Emergency Response Networks: Evacuation Response and Texas School Districts

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    Studies of collaborative public management have relied on a number of concepts that are time-bound. Collaborative networks rely on trust and stable expectations – both elements that have strong temporal elements. Despite this attention, there has been less research into the evolution of collaborative relationships than one would expect – especially using large-N quantitative methodologies. This is due in part to the methodological difficulties of studying relationships across time using survey methodologies. This paper reports results from two surveys of school districts immediately following Hurricane Katrina that asked about their collaborative relationships – including whether they continued collaboration more than a year after the hurricanes. The results suggest that organizational structure plays the largest role in determining whether organizations maintain collaborative relationships

    Geochemistry and petrology of the Lake Vermilion Formation, Ely Greenstone Belt, northeastern Minnesota

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    Alteration in the Lake Vermilion Formation took place at low water/rock ratios. Calculations using the method of Grescens (1967) indicate that the amount of open-system elemental exchange was slight. During secondary alteration, Ca, Na, K, Rb, Sr, and Ba were very mobile; Mg and Fe were less mobile; Si, Al, Ti, Zr, Y, and Ni were slightly mobile. Chemically the rocks resemble modern spilites and keratophyres. The dacites and basalts are depleted in Ti, Zr, and Y relative to Tertiary igneous rocks of similar composition. The Lake Vermilion Formation basalts display a volcanic arc basalt trend of constant Ti02 with increasing Zr, similar to low-K tholeiites of the island arc tholeiitic series. The few Lower Ely basalt .samples are similar. The Upper Ely samples display a trend of increasing Ti~ with increasing Zr, similar to ocean-floor basalts. The Vermilion igneous rocks\u27 Ti-Zr-Y systematics are of the convergent plate-margin Andean type of Pearce and Norry ( 1979). Partial melting of mantle peridotite could produce the Ti-Zr-Y covariations observed in the basalts. Partial melting of amphibolite or eclogite with biotite in the residuum could produce the Ti-Zr-Y trend observed in the dacites. The graywackes of the Lake Vermilion Formation have compositions resembling the dacites and are derived from them. The chloritic facies graywackes may be equivalents of the biotitic graywackes which have been subjected to retrograde metamorphism. The slates and many graywackes are higher in Fe203T, MgO, Ni, and Cr than the dacites, indicating the presence of mafic components or derivation from intermediate (andesitic) volcanics. No evidence for plutonic components in the LVF graywackes was found. The Vermilion igneous and sedimentary rocks closely resemble rocks formed in young ensimatic island arcs in their chemistry, mineralogy, and abundance of rock types. Formation of the district by an accretionary-tectonic mechanism could explain its structural and geochemical characteristics

    A Collaborative Process for Developing Map Symbol Standards

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    AbstractGeographic information is commonly disseminated and consumed via visual representations of features and their environmental context on maps. Map design inherently involves generalizing reality, and one method by which mapmakers do so is through the use of symbols to represent features. Here we focus on the challenges associated with supporting mapmakers who need to work together to reach consensus on standardizing their map symbols. Based on a needs assessment study with mapmakers at the U.S. Department of Homeland Security, we designed a new, mixed-method symbol standardization process that takes place through a web-based, asynchronous platform. A study to test this new standardization process with mapmakers at DHS revealed that our process allowed participants to identify many issues related to symbol design, meaning, and categorization. The approach elicited sustained, iterative engagement and critical thinking from participants, and results from a post-study survey indicate that participants found it to be useful and usable. Results from our study and user feedback allow us to suggest multiple ways in which our approach and platform can be improved for future applications

    The SCUBA 8-mJy survey - I: Sub-millimetre maps, sources and number counts

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    We present maps, source lists, and number counts from the largest, unbiassed, extragalactic sub-mm survey so far undertaken with the SCUBA camera on the JCMT. Our maps cover 260 sq. arcmin, to a noise level S(850)=2.5 mJy/beam. We have reduced the data using both SURF, and our own pipeline which produces zero-footprint maps and noise images. The uncorrelated noise maps produced by the latter approach have allowed application of a maximum-likelihood method to measure the statistical significance of each peak, leading to properly quantified flux-density errors for all potential sources. We detect 19 sources with S/N > 4, 38 with S/N > 3.5, and 72 with S/N > 3. To assess completeness and the impact of source confusion we have applied our source extraction algorithm to a series of simulated images. The result is a new estimate of the sub-mm source counts in the flux-density range S(850)=5-15mJy, which we compare with other estimates, and with model predictions. Our estimate of the cumulative source count at S(850) > 8 mJy is 320 (+80,-100) per square degree. Assuming that the majority of sources have z > 1.5, the co-moving number density of high-z galaxies forming stars at a rate >1000 solar masses per year is 10^-5 per Mpc^3, with only a weak dependence on the precise redshift distribution. This number density corresponds to that of massive ellipticals with L > 3-4 L* at low redshift and is also the same as the co-moving number density of comparably massive, passively-evolving objects in the redshift band 1<z<2 inferred from recent surveys of extremely red objects. Thus the bright sub-mm sources can plausibly account for the formation of all present-day massive ellipticals. Improved z constraints, and a proper measurement of sub-mm clustering can refine or refute this picture.Comment: Minor revisions. 27 pages, 13 figures. Higher resolution versions of Figs 5,6,7 and 8 are available from the autho

    Differential expression of microRNA-206 and its target genes in pre-eclampsia

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    Objectives: Pre-eclampsia is a multi-system disease that significantly contributes to maternal and fetal morbidity and mortality. In this study, we used a non-biased microarray approach to identify novel circulating miRNAs in maternal plasma that may be associated with pre-eclampsia. Methods: Plasma samples were obtained at 16 and 28 weeks of gestation from 18 women who later developed pre-eclampsia (cases) and 18 matched women with normotensive pregnancies (controls). We studied miRNA expression profiles in plasma and subsequently confirmed miRNA and target gene expression in placenta samples. Placental samples were obtained from an independent cohort of 19 women with pre-eclampsia matched with 19 women with normotensive pregnancies. Results: From the microarray, we identified 1 miRNA that was significantly differentially expressed between cases and controls at 16 weeks of gestation and 6 miRNAs that were significantly differentially expressed at 28 weeks. Following qPCR validation only one, miR-206, was found to be significantly increased in 28 week samples in women who later developed pre-eclampsia (1.4 fold change ± 0.2). The trend for increase in miR-206 expression was mirrored within placental tissue from women with pre-eclampsia. In parallel, IGF-1, a target gene of miR-206, was also found to be down-regulated (0.41 ± 0.04) in placental tissue from women with pre-eclampsia. miR-206 expression was also detectable in myometrium tissue and trophoblast cell lines. Conclusions: Our pilot study has identified miRNA-206 as a novel factor up-regulated in pre-eclampsia within the maternal circulation and in placental tissue

    Public Support for the Department of Homeland Security

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    The creation of the Department of Homeland Security was a landmark in the history of the U.S. federal government. With the largest reorganization of the federal executive branch in decades, policymakers sought to group agencies with missions related to homeland security under one cabinet level official. It is natural to ask whether this reorganization has succeeded. One measure of that success would be public confidence in the competency of the department. In this paper, we report the results of a national poll which asked a variety of questions related to individuals’ perceptions of the Department of Homeland Security. The results illustrate that the level of confidence in the competency of the Department of Homeland Security is generally high—though there are divisions among people’s evaluations based on party, religiosity, attention to terrorism, and education level.This material is based upon work supported by the U.S. Department of Homeland Security under Grant Award Number 2008-DN-077-ARI018-03.Ye

    Resolved Mid-IR Emission in the Narrow Line Region of NGC 4151

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    We present subarcsecond resolution mid infrared images of NGC 4151 at 10.8 micron and 18.2 micron. These images were taken with the University of Florida mid-IR camera/spectrometer OSCIR at the Gemini North 8-m telescope. We resolve emission at both 10.8 micron and 18.2 micron extending ~ 3.5" across at a P.A. of ~ 60 degrees. This coincides with the the narrow line region of NGC 4151 as observed in [OIII] by the Hubble Space Telescope. The most likely explanation for this extended mid-IR emission is dust in the narrow line region heated by a central engine. We find no extended emission associated with the proposed torus and place an upper limit on its mid-IR size of less than or equal to ~ 35 pc.Comment: accepted for publication in the Astrophysical Journal, 19 pages including 5 figure

    Discovery and characterization of a new class of O-linking oligosaccharyltransferases from the Moraxellaceae family

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    Bacterial protein glycosylation is commonly mediated by oligosaccharyltransferases (OTases) that transfer oligosaccharides en bloc from preassembled lipid-linked precursors to acceptor proteins. Natively, O-linking OTases usually transfer a single repeat unit of the O-antigen or capsular polysaccharide to the side chains of serine or threonine on acceptor proteins. Three major families of bacterial O-linking OTases have been described: PglL, PglS, and TfpO. TfpO is limited to transferring short oligosaccharides both in its native context and when heterologously expressed in glycoengineered Escherichia coli. On the other hand, PglL and PglS can transfer long-chain polysaccharides when expressed in glycoengineered E. coli. Herein, we describe the discovery and functional characterization of a novel family of bacterial O-linking OTases termed TfpM from Moraxellaceae bacteria. TfpM proteins are similar in size and sequence to TfpO enzymes but can transfer long-chain polysaccharides to acceptor proteins. Phylogenetic analyses demonstrate that TfpM proteins cluster in distinct clades from known bacterial OTases. Using a representative TfpM enzyme from Moraxella osloensis, we determined that TfpM glycosylates a C-terminal threonine of its cognate pilin-like protein and identified the minimal sequon required for glycosylation. We further demonstrated that TfpM has broad substrate tolerance and can transfer diverse glycans including those with glucose, galactose, or 2-N-acetyl sugars at the reducing end. Last, we find that a TfpM-derived bioconjugate is immunogenic and elicits serotype-specific polysaccharide IgG responses in mice. The glycan substrate promiscuity of TfpM and identification of the minimal TfpM sequon renders this enzyme a valuable additional tool for expanding the glycoengineering toolbox
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