Characteristics of those who participated in the study.

<p>Characteristics of those who participated in the study.</p

Flow chart of patient recruitment.

<p>Flow chart of patient recruitment.</p

Clinical characteristics and outcomes of Gold standards Framework (GSF) positive (defined as meeting 1 general criterion and 2 heart disease criteria) versus Gold Standards Framework negative patients.

<p>Clinical characteristics and outcomes of Gold standards Framework (GSF) positive (defined as meeting 1 general criterion and 2 heart disease criteria) versus Gold Standards Framework negative patients.</p

Baseline patient characteristics and alive versus dead by 12 months comparison.

<p>P values for alive versus dead comparison, GSF – Gold Standards Framework, SD standard deviation, ST – electrocardiogram ST segment, COPD – chronic obstructive pulmonary disease, CKD – chronic kidney disease.</p

Univariate and multivariate analysis of factors predicting all-cause mortality.

1<p>p value from Kaplan Meier log-rank test.</p>2<p>p value from Cox-regression analysis.</p>3<p>No patient with less than 25 g/dl albumin.</p>4<p>CKD is not independent risk factor as creatinine level included in GRACE score.</p

ROC curve for predicted mortality from GRACE risk alone and combination of GRACE risk with previous stroke and previous hospital admissions.

<p>ROC curve for predicted mortality from GRACE risk alone and combination of GRACE risk with previous stroke and previous hospital admissions.</p

Kaplan-Meier survival curves for factors independently predicting all-cause mortality.

<p>Kaplan-Meier survival curves for factors independently predicting all-cause mortality.</p

Characteristics of included studies.

<p>Characteristics of included studies.</p

Risk of bias in included studies.

*<p>Clarified by author on request.</p>‡<p>Blinding of participants not possible.</p

Sensitivity and specificity of prognostic scores.

<p>NPV – negative predictive value, PPV – positive predictive value, GSF – Gold Standards Framework criteria positive, GRACE – Global Registry of Acute Coronary Events.</p