Distributions of age at acute infection, for PWID and non-PWID.

<p>Distributions of age at acute infection, for PWID and non-PWID.</p

Projected HCV-related disease burden in DALYs/year, over the period 1960–2039.

<p>Three historical incidence scenarios are compared (1-B, 2-B, and 3-B), with current treatment uptake and SVR rates assumed to apply to the year 2014 onwards.</p

Patterns of acute incidence underlying Scenarios 1 to 3.

<p>The assumed historical HCV incidence time series for Scenarios 1 to 3 are shown separately for PWID and non-PWID risk groups (upper, centre, and lower panels, respectively).</p

Progression probabilities for transitions between disease progression model states, and corresponding prior distributions.

<p>Background mortality probabilities were derived from the national age-specific mortality rates for Malaysia, adjusted for the degree of excess non-liver-related mortality calculated from persons diagnosed HCV Ab+ in Scotland (1991–2005), in which the window of 6 months subsequent to HCV diagnosis date is excluded from follow-up time to reduce bias associated with testing individuals presenting with disease.</p><p>Progression probabilities for transitions between disease progression model states, and corresponding prior distributions.</p

Projections of HCV-related disease outcomes for Scenario 1-B, over the period 1960–2039.

<p>Projected incidence and prevalence are shown in the upper and lower panels, respectively.</p

Average annual disease burden in the Netherlands in 2007–2011 for new cases of sexually-transmitted infections.

<p>YLD and YLL components are shown separately. Red lines indicate 95% uncertainty intervals.(DALY = Disability-Adjusted Life Year, YLD = Years Lived with Disability, YLL = Years of Life Lost).</p

Average annual disease burden in the Netherlands in 2007–2011 for new cases of respiratory diseases.

<p>YLD and YLL components are shown separately. Red lines indicate 95% uncertainty intervals. (DALY = Disability-Adjusted Life Year, YLD = Years Lived with Disability, YLL = Years of Life Lost).</p

Ranking of respiratory diseases by disease burden at population/individual level in the Netherlands in 2007–2011.

<p>The area of each bubble is proportional to the average number of estimated annual cases. Both axes are on a logarithmic scale. (DALY = Disability-Adjusted Life Years, population level = number of DALYs/year, individual level = number of DALYs/100 infections).</p

Ranking of food-related diseases by disease burden at population/individual level in the Netherlands in 2007–2011.

<p>The area of each bubble is proportional to the average number of estimated annual cases (200 cases were added to each bubble for visibility reasons). Both axes are on a logarithmic scale. (DALY = Disability-Adjusted Life Years, population level = number of DALYs/year, individual level = number of DALYs/100 infections).</p

Ranking of vaccine-preventable diseases by disease burden at population/individual level in the Netherlands in 2007–2011.

<p>Diphtheria and poliomyelitis could not be included because there were no cases reported in this period. The area of each bubble is proportional to the average number of estimated annual cases (50 cases were added to each bubble for visibility reasons). Both axes are on a logarithmic scale. (DALY = Disability-Adjusted Life Years, population level = number of DALYs/year, individual level = number of DALYs/100 infections, I. = invasive).</p