Another Look at Confidence Intervals: Proposal for a More Relevant and Transparent Approach

The behaviors of various confidence/credible interval constructions are explored, particularly in the region of low statistics where methods diverge most. We highlight a number of challenges, such as the treatment of nuisance parameters, and common misconceptions associated with such constructions. An informal survey of the literature suggests that confidence intervals are not always defined in relevant ways and are too often misinterpreted and/or misapplied. This can lead to seemingly paradoxical behaviours and flawed comparisons regarding the relevance of experimental results. We therefore conclude that there is a need for a more pragmatic strategy which recognizes that, while it is critical to objectively convey the information content of the data, there is also a strong desire to derive bounds on models and a natural instinct to interpret things this way. Accordingly, we attempt to put aside philosophical biases in favor of a practical view to propose a more transparent and self-consistent approach that better addresses these issues.Comment: 23 pages, 11 figure

Impacts of Urbanization on Base Flow and Recharge Rates, Northeastern Illinois: Summary of Year 1 Activities

During year one of a two-year project to investigate the impacts of urbanization on base flow and ground-water recharge rates in northeastern Illinois, three gaged watersheds in urbanized areas of northeastern Illinois, and one watershed located in rural northwestern Illinois, have been selected for study. The gages have a common period of record extending from October 1952 through the present, a period during which the northeastern Illinois watersheds underwent substantial urbanization. Mean daily discharge data from the gages have been analyzed using an automated hydrograph separation technique, and monthly estimates of mean total discharge, base flow, and direct runoff have been calculated. Spearman rank correlation coefficients indicate a stronger correlation between precipitation and total discharge, base flow, and direct runoff in the northeastern Illinois watersheds than in the rural watershed. Smoothed time-series plots of total discharge, base flow, and direct runoff in the urban watersheds are less consistent with precipitation than similar plots constructed from the rural watershed data. The trends indicate that rates of direct runoff have overtaken rates of base flow in two of the three northeastern Illinois watersheds, but in one of these watersheds, this relationship probably reflects the cessation of effluent discharges to the stream. In general, double-mass curve analysis suggests that, relative to the rural watershed, base flow in the urban watersheds has proportionally decreased, and direct runoff has proportionally increased. The trends suggested by the smoothed time-series plots and the double-mass curves are consistent with a conceptual model of the northeastern Illinois watersheds in which sewering and impervious surfaces have reduced infiltration, and thence ground-water recharge and base flow, in the watersheds.Ope

A knowledge discovery object model API for Java

BACKGROUND: Biological data resources have become heterogeneous and derive from multiple sources. This introduces challenges in the management and utilization of this data in software development. Although efforts are underway to create a standard format for the transmission and storage of biological data, this objective has yet to be fully realized. RESULTS: This work describes an application programming interface (API) that provides a framework for developing an effective biological knowledge ontology for Java-based software projects. The API provides a robust framework for the data acquisition and management needs of an ontology implementation. In addition, the API contains classes to assist in creating GUIs to represent this data visually. CONCLUSIONS: The Knowledge Discovery Object Model (KDOM) API is particularly useful for medium to large applications, or for a number of smaller software projects with common characteristics or objectives. KDOM can be coupled effectively with other biologically relevant APIs and classes. Source code, libraries, documentation and examples are available at

A trusted analyst’s opinion is worth gold for a company’s investors

It weighs more than a respected CEO's word, write Steven Boivie, Scott D. Graffin and Richard Gentr

Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis.

Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance. These strategies include heightening T-cell response and vaccine induction of anti-cancer memory against tumor-associated antigens. Early investigations with chimeric antigen receptor T cells (CAR-T cells), vaccine-based therapies, dendritic cells (DCs) in combination with pro-inflammatory cytokines and natural killer cells (NKs), adoptive cell transfer, and immune checkpoint inhibitors represent significant advances in the treatment of PM. IP delivery of CAR-T cells has shown demonstrable suppression of tumors expressing carcinoembryonic antigen. This response was enhanced when IP injected CAR-T cells were combined with anti-PD-L1 or anti-Gr1. Similarly, CAR-T cells against folate receptor α expressing tumors improved T-cell tumor localization and survival when combined with CD137 co-stimulatory signaling. Moreover, IP immunotherapy with catumaxomab, a trifunctional antibody approved in Europe, targets epithelial cell adhesion molecule (EpCAM) and has shown considerable promise with control of malignant ascites. Herein, we discuss immunologic approaches under investigation for treatment of PM

G02-1466 Determining the Need to Fertilize Landscape Trees and Shrubs (Revised March 2004)

Most Nebraska soils are fertile enough to support tree and shrub growth without applying fertilizer. However, when woody plants exhibit poor growth or reduced vigor, yet have had adequate moisture and are not experiencing pest problems or other environmental limitations, the proper applicatin of fertilizer may be necessary. This NebGuide explains how to determine if fertilization of established trees and shrubs is required and how to apply the needed amount

Breast cancer risk and imprinting methylation in blood

Date of Acceptance: 17/08/2015 Acknowledgements This study was supported by the Breast Cancer Campaign (2008MayPR46) and Fraserburgh Moonlight Prowl Breast Cancer Charity. PH, GH and GWH acknowledge the support of the Scottish Government. We would like to thank Val Bain and Michela Donnarumma for help with the data and sample collection.Peer reviewedPublisher PD