Modelling of imbibition process in an embankment scale model

This paper aims to investigate the hydro-mechanical behaviour of a loosely compacted embankment during an inundation event. This study is based on the results of a centrifuge test carried out on a small-scale embankment model made of an artificially compacted clay–sand mixture. The wetting-induced displacements are analyzed and interpreted by means of a constitutive model adapted to unsaturated conditions. The numerical predictions are presented in terms of time evolutions of settlements, as well as, spatial distributions of vertical displacements. These profiles are compared to those experimentally observed in order to validate the predictive capabilities of the model on a boundary value problem. Moreover, the stress paths followed by elementary soil elements located at different depths are analyzed to emphasize the stress and strain variations due to capillary rise

Deconfinement critical point of lattice QCD with Nf=2N_{\rm f}=2 Wilson fermions

The ${\rm SU}(3)$ pure gauge theory exhibits a first-order thermal deconfinement transition due to spontaneous breaking of its global $Z_3$ center symmetry. When heavy dynamical quarks are added, this symmetry is broken explicitly and the transition weakens with decreasing quark mass until it disappears at a critical point. We compute the critical hopping parameter and the associated pion mass for lattice QCD with $N_f=2$ degenerate standard Wilson fermions on $N_\tau\in\{6,8,10\}$ lattices, corresponding to lattice spacings $a=0.12\, {\rm fm}$, $a=0.09\, {\rm fm}$, $a=0.07\, {\rm fm}$, respectively. Significant cut-off effects are observed, with the first-order region growing as the lattice gets finer. While current lattices are still too coarse for a continuum extrapolation, we estimate $m_\pi^c\approx 4 {\rm GeV}$ with a remaining systematic error of $\sim 20\%$. Our results allow to assess the accuracy of the LO and NLO hopping expanded fermion determinant used in the literature for various purposes. We also provide a detailed investigation of the statistics required for this type of calculation, which is useful for similar investigations of the chiral transition.Comment: 12 pages, 6 figures, minor changes to match the version published in PR

Laparoscopic versus open radical prostatectomy in high prostate volume cases: impact on oncological and functional results

To prospectively compare the laparoscopic versus open approach to RP in cases with high prostate volume and to evaluate a possible diferente impact of prostate volume

Geological and geomorphological analysis of a complex landslides system: the case of San Martino sulla Marruccina (Abruzzo, Central Italy)

This work deals with the landslides affecting the area surrounding the village of San Martino sulla Marrucina and involving the neighboring municipalities of Casacanditella and Filetto. The geological and geomorphological settings of this area are being discussed. The enclosed maps have been realized following a multidisciplinary approach, based on morphometric, geological, and geomorphological analyses and supported by air-photo interpretation, dendrochronology, and satellite SAR interferometry (InSAR). The map is organized in four sections: orography (on the upper part), geological map (on the upper right part), main geomorphological map (in the central left part, 1:7,500 scale), and multitemporal analysis (in the lower part). The aforementioned multi-temporal assessment of landslides was performed according to the geomorphological evidence-based criteria and the past ground displacement measurements were obtained by dendrochronology and InSAR. The aim of the study is to understand the evolution in time and space of this landslide area, focusing on the corresponding kinematics

Variability analysis of muscle activation symmetry to identify indicators of individual motor strategy: a case series on elite Paralympic powerlifters

IntroductionIn Paralympic powerlifting competitions, movement execution symmetry is a technical requirement influenced by individual athlete characteristics and motor strategies. Identifying the elements associated with individual motor strategies can offer valuable insight for improving sport performance. Therefore, this case series study aimed to explore muscle activation symmetry and its intra- and inter-individual variability to determine the muscles mostly related to individual motor strategies in elite Paralympic powerlifters.MethodsBilateral electromyographic activation of the anterior deltoid (AD), pectoralis major (PM), latissimus dorsi (LD), triceps (TRI) and external oblique (EO) muscles were analysed in five elite Paralympic powerlifters while performing four sets of one-repetition maximum of Paralympic bench press. Muscle activation symmetry indexes (SI) were obtained and transformed to consider individual-independent evaluation. The coefficient of variation (CV), variance ratio (VR), and mean deviation (MD) were computed to assess inter- and intra-individual variability in electromyographic waveforms and SI.ResultsBoth transformed and non-transformed SI indicated overall symmetric activation in DA, PM, TRI, and LD. Transformed SI revealed asymmetrical muscle activation of EO when grouping data (mean bilateral difference: 10%). Athletes exhibited low intra-individual SI variability in all analysed muscles (CV < 10%) and low inter-individual variability in DA, PM, LD, and TRI (CV < 10%; VR: 4%–11%; MD: 29%–43%). In contrast, higher inter-individual variability was observed in EO (CV: 23%; VR: 23%; MD: 72%–81%).ConclusionThe highest variability and asymmetry in abdominal muscle activation among athletes emphasize the importance of personalized training approaches for targeting these muscles due to their role in individualizing motor strategies

Cellular immune profiling of lung and blood compartments in patients with SARS-CoV-2 infection

Background: SARS-CoV-2 related immunopathology may be the driving cause underlying severe COVID-19. Through an immunophenotyping analysis on paired bronchoalveolar lavage fluid (BALF) and blood samples collected from mechanically ventilated patients with COVID-19-associated Acute Respiratory Distress Syndrome (CARDS), this study aimed to evaluate the cellular immune responses in survivors and non-survivors of COVID-19. Methods: A total of 36 paired clinical samples of bronchoalveolar lavage fluid (BALF) mononuclear cells (BALF-MC) and peripheral blood mononuclear cells (PBMC) were collected from 18 SARS-CoV-2-infected subjects admitted to the intensive care unit (ICU) of the Policlinico Umberto I, Sapienza University Hospital in Rome (Italy) for severe interstitial pneumonia. The frequencies of monocytes (total, classical, intermediate and non-classical) and Natural Killer (NK) cell subsets (total, CD56bright and CD56dim), as well as CD4+ and CD8+ T cell subsets [naïve, central memory (TCM) and effector memory (TEM)], and those expressing CD38 and/or HLADR were evaluated by multiparametric flow cytometry. Results: Survivors with CARDS exhibited higher frequencies of classical monocytes in blood compared to non-survivors (p < 0.05), while no differences in the frequencies of the other monocytes, NK cell and T cell subsets were recorded between these two groups of patients (p > 0.05). The only exception was for peripheral naïve CD4+ T cells levels that were reduced in non-survivors (p = 0.04). An increase in the levels of CD56bright (p = 0.012) and a decrease in CD56dim (p = 0.002) NK cell frequencies was also observed in BALF-MC samples compared to PBMC in deceased COVID-19 patients. Total CD4+ and CD8+ T cell levels in the lung compartment were lower compared to blood (p = 0.002 and p < 0.01, respectively) among non-survivors. Moreover, CD38 and HLA-DR were differentially expressed by CD4+ and CD8+ T cell subsets in BALF-MC and in PBMC among SARS-CoV-2-infected patients who died from COVID-19 (p < 0.05). Conclusions: These results show that the immune cellular profile in blood and pulmonary compartments was similar in survivors and non-survivors of COVID-19. T lymphocyte levels were reduced, but resulted highly immune-activated in the lung compartment of patients who faced a fatal outcome