Antifungal and antimycobacterial activity of new N1-[1-aryl-2-(1H-Imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-ethylidene]-pyridine-2-carboxamidrazone derivatives: A combined experimental and computational approach.

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"The integration of active elements in composite laminates for space applications"

Technomi

Synthesis and antimycobacterial activity of 1,3,4-oxadiazol-2-one derivatives.

Tuberculosis is a contagious disease with high mortality worldwide. The recent emergence of cases of multidrug resistant tuberculosis (MDR-TB) becomes a serious problem to the treatment of the disease. The disease resurgence in most countries is due to the human immunodeficiency virus (HIV) epidemic, in addition to the emergence of drug-resistant strains and immigration from high-prevalence countries. Moreover, species of mycobacteria other than M. tuberculosis (MOTT) are able to cause a wide range of infections. Among these bacteria, the most dangerous for humans are M. avium, M. fortuitum, M. kansasii, M. chelonei and the M. avium-intracellulare complex (MAC). Therefore, new drugs for the treatment of infection sustained by MOTT and strains of MDR mycobacteria are indispensable

Experimental Characterization of Knitted Meshes Through Image Analysis

The modelling of knitted meshes requires an accurate strain analysis on the basis of gathered experimental data. In the use of metallic nets for assembling a space antenna, from the point of view of electromagnetic efficiency, it is essential to outline a correlation among the strains imposed while mounting the net, the thermal effects on duty and the effective loop dimensions. This paper deals with the activities that can be carried out through image analysis to characterize the net behaviour

Experimental Characterization of Knitted Meshes Through Image Analysis

The modelling of knitted meshes requires an accurate strain analysis on the basis of gathered experimental data. In the use of metallic nets for assembling a space antenna, from the point of view of electromagnetic efficiency, it is essential to outline a correlation among the strains imposed while mounting the net, the thermal effects on duty and the effective loop dimensions. This paper deals with the activities that can be carried out through image analysis to characterize the net behaviour

2-Aryl-3-(1H-azol-1-yl)-1H-indole derivatives: a new class of antimycobacterial compounds. Convetional heating in comparison with MW-assisted synthesis.

2-Aryl-3-(1H-imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-1H-indole derivatives were synthesized and tested for their in-vitro antifungal and antimycobacterial activities. These indole derivatives were devoid of antifungal activity against the tested strains of Candida spp. Yet, they exhibited an interesting antitubercular activity against Mycobacterium tuberculosis reference strain H(37)Rv

Synthesis and antifungal activity of new N-[1-aryl-2-(1H-imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-1-ethylidene]-N'-phenylhydrazine derivatives.

Search of new antifungal compounds was performed through a preliminary computer modeling of drug/enzymecomplexes. All compounds have been tested against a strain of Candida Albicans 3038 and a strain of Mycobacterium tuberculosis H37Rv to evaluate the antifungal and the antimycobacterial activity respectively

\u201cSynthesis and antifungal activity of new N-[1-aryl-2-(1H-imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-1-ethylidene]-N\u2019-2,4-dichloro-phenylhydrazine derivatives\u201d.

Systemic fungal infections have emerged as important causes of morbidity and mortality in immunocompromised patients (e.g., AIDS, cancer chemotherapy, organ or bone marrow transplantation). In addition, hospital-related infections in patients not previously considered at risk (e.g. patients on an intensive care unit) have become a cause of major health concern. An the other hand the increased incidence of severe opportunistic fungal infection together with the rise up of resistance to many antifungal drugs bring to need to development of new antifungal compounds. The azole compounds interact at the target enzyme cytocrome P450-dependent lanosterol 14\u3b1-demethylase in the ergosterol-biosynthesis pathway. Our search of new antifungal compounds was performed through a preliminary computer modeling of drug/enzyme complexes beginning from N1-[1-aryl-2-(1H-imidazol-1-yl and 1H-1,2,4-triazol-1-yl)ethylidene]-pyridine-2-carboxamidrazone derivates (1)[1]. Some of these compounds have exhibited a remarkable antifungal activity