Antifungal and antimycobacterial activity of new N1-[1-aryl-2-(1H-Imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-ethylidene]-pyridine-2-carboxamidrazone derivatives: A combined experimental and computational approach.

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Synthesis and antimycobacterial activity of 1,3,4-oxadiazol-2-one derivatives.

Tuberculosis is a contagious disease with high mortality worldwide. The recent emergence of cases of multidrug resistant tuberculosis (MDR-TB) becomes a serious problem to the treatment of the disease. The disease resurgence in most countries is due to the human immunodeficiency virus (HIV) epidemic, in addition to the emergence of drug-resistant strains and immigration from high-prevalence countries. Moreover, species of mycobacteria other than M. tuberculosis (MOTT) are able to cause a wide range of infections. Among these bacteria, the most dangerous for humans are M. avium, M. fortuitum, M. kansasii, M. chelonei and the M. avium-intracellulare complex (MAC). Therefore, new drugs for the treatment of infection sustained by MOTT and strains of MDR mycobacteria are indispensable

2-Aryl-3-(1H-azol-1-yl)-1H-indole derivatives: a new class of antimycobacterial compounds. Convetional heating in comparison with MW-assisted synthesis.

2-Aryl-3-(1H-imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-1H-indole derivatives were synthesized and tested for their in-vitro antifungal and antimycobacterial activities. These indole derivatives were devoid of antifungal activity against the tested strains of Candida spp. Yet, they exhibited an interesting antitubercular activity against Mycobacterium tuberculosis reference strain H(37)Rv

Synthesis and antifungal activity of new N-[1-aryl-2-(1H-imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-1-ethylidene]-N'-phenylhydrazine derivatives.

Search of new antifungal compounds was performed through a preliminary computer modeling of drug/enzymecomplexes. All compounds have been tested against a strain of Candida Albicans 3038 and a strain of Mycobacterium tuberculosis H37Rv to evaluate the antifungal and the antimycobacterial activity respectively

Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides

Monogalactosyl diglycerides with medium to long fatty acid acyl chains, were prepared and examined for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The study of their in vitro antimicrobial activity confirms the significant activity of some monogalactosyl diacylglycerol analogues and establishes for the galactose series that the 1,2-disubstitution and the octanoyl chain are the proper structural features for the maximum activity