27,654 research outputs found

    In-flight calibration of the Herschel-SPIRE instrument

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    SPIRE, the Spectral and Photometric Imaging REceiver, is the Herschel Space Observatory's submillimetre camera and spectrometer. It contains a three-band imaging photometer operating at 250, 350 and 500 Ī¼m, and an imaging Fourier-transform spectrometer (FTS) covering 194ā€“671 Ī¼m (447-1550 GHz). In this paper we describe the initial approach taken to the absolute calibration of the SPIRE instrument using a combination of the emission from the Herschel telescope itself and the modelled continuum emission from solar system objects and other astronomical targets. We present the photometric, spectroscopic and spatial accuracy that is obtainable in data processed through the ā€œstandardā€ pipelines. The overall photometric accuracy at this stage of the mission is estimated as 15% for the photometer and between 15 and 50% for the spectrometer. However, there remain issues with the photometric accuracy of the spectra of low flux sources in the longest wavelength part of the SPIRE spectrometer band. The spectrometer wavelength accuracy is determined to be better than 1/10th of the line FWHM. The astrometric accuracy in SPIRE maps is found to be 2 arcsec when the latest calibration data are used. The photometric calibration of the SPIRE instrument is currently determined by a combination of uncertainties in the model spectra of the astronomical standards and the data processing methods employed for map and spectrum calibration. Improvements in processing techniques and a better understanding of the instrument performance will lead to the final calibration accuracy of SPIRE being determined only by uncertainties in the models of astronomical standards

    Computations in Large N Matrix Mechanics

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    The algebraic formulation of Large N matrix mechanics recently developed by Halpern and Schwartz leads to a practical method of numerical computation for both action and Hamiltonian problems. The new technique posits a boundary condition on the planar connected parts X_w, namely that they should decrease rapidly with increasing order. This leads to algebraic/variational schemes of computation which show remarkably rapid convergence in numerical tests on some many- matrix models. The method allows the calculation of all moments of the ground state, in a sequence of approximations, and excited states can be determined as well. There are two unexpected findings: a large d expansion and a new selection rule for certain types of interaction.Comment: 27 page

    The Induced Magnetic Field of the Moon: Conductivity Profiles and Inferred Temperature

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    Electromagnetic induction in the moon driven by fluctuations of the interplanetary magnetic field is used to determine the lunar bulk electrical conductivity. The present data clearly show the north-south and east-west transfer function difference as well as high frequency rollover. The difference is shown to be compatible over the mid-frequency range with a noise source associated with the compression of the local remanent field by solar wind dynamic pressure fluctuations. Models for two, three, and four layer; current layer, double current layer, and core plus current layer moons are generated by inversion of the data using a theory which incorporates higher order multipoles. Core radii conductivities generally are in the range 1200 to 1300 km and 0.001 to 0.003 mhos/m; and for the conducting shell 1500 to 1700 km with 0.0001 to 0.0007 mhos/m with an outer layer taken as nonconducting. Core temperature based on available olivine data is 700 to 1000 C

    Efficient Multi-Robot Motion Planning for Unlabeled Discs in Simple Polygons

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    We consider the following motion-planning problem: we are given mm unit discs in a simple polygon with nn vertices, each at their own start position, and we want to move the discs to a given set of mm target positions. Contrary to the standard (labeled) version of the problem, each disc is allowed to be moved to any target position, as long as in the end every target position is occupied. We show that this unlabeled version of the problem can be solved in O(nlogā”n+mn+m2)O(n\log n+mn+m^2) time, assuming that the start and target positions are at least some minimal distance from each other. This is in sharp contrast to the standard (labeled) and more general multi-robot motion-planning problem for discs moving in a simple polygon, which is known to be strongly NP-hard

    PCN38 ā€œCOST OF ILLNESSā€ ANALYSIS OF RENAL CELL CARCINOMA

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    Apparent Activation Energies Associated with Protein Dynamics on Hydrophobic and Hydrophilic Surfaces

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    AbstractWith the use of single-molecule total internal reflection fluorescence microscopy (TIRFM), the dynamics of bovine serum albumin (BSA) and human fibrinogen (Fg) at low concentrations were observed at the solid-aqueous interface as a function of temperature on hydrophobic trimethylsilane (TMS) and hydrophilic fused silica (FS) surfaces. Multiple dynamic modes and populations were observed and characterized by their surface residence times and squared-displacement distributions (surface diffusion). Characteristic desorption and diffusion rates for each population/mode were generally found to increase with temperature, and apparent activation energies were determined from Arrhenius analyses. The apparent activation energies of desorption and diffusion were typically higher on FS than on TMS surfaces, suggesting that protein desorption and mobility were hindered on hydrophilic surfaces due to favorable protein-surface and solvent-surface interactions. The diffusion of BSA on TMS appeared to be activationless for several populations, whereas diffusion on FS always exhibited an apparent activation energy. All activation energies were small in absolute terms (generally only a few kBT), suggesting that most adsorbed protein molecules are weakly bound and move and desorb readily under ambient conditions

    Measurement error caused by spatial misalignment in environmental epidemiology

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    Copyright @ 2009 Gryparis et al - Published by Oxford University Press.In many environmental epidemiology studies, the locations and/or times of exposure measurements and health assessments do not match. In such settings, health effects analyses often use the predictions from an exposure model as a covariate in a regression model. Such exposure predictions contain some measurement error as the predicted values do not equal the true exposures. We provide a framework for spatial measurement error modeling, showing that smoothing induces a Berkson-type measurement error with nondiagonal error structure. From this viewpoint, we review the existing approaches to estimation in a linear regression health model, including direct use of the spatial predictions and exposure simulation, and explore some modified approaches, including Bayesian models and out-of-sample regression calibration, motivated by measurement error principles. We then extend this work to the generalized linear model framework for health outcomes. Based on analytical considerations and simulation results, we compare the performance of all these approaches under several spatial models for exposure. Our comparisons underscore several important points. First, exposure simulation can perform very poorly under certain realistic scenarios. Second, the relative performance of the different methods depends on the nature of the underlying exposure surface. Third, traditional measurement error concepts can help to explain the relative practical performance of the different methods. We apply the methods to data on the association between levels of particulate matter and birth weight in the greater Boston area.This research was supported by NIEHS grants ES012044 (AG, BAC), ES009825 (JS, BAC), ES007142 (CJP), and ES000002 (CJP), and EPA grant R-832416 (JS, BAC)
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